Characterization of skeletal phenotypes of TRα1PV and TRβPV mutant mice: implications for tissue thyroid status and T3 target gene expression
Open accessAbstract
Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) alpha1 or beta gene. This perspective summarizes our findings to date and explores the wider implications for thyroid status and T3 target gene expression in individual tissues.
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Analysis of the skeletal consequences of mutations of Thrb in mouse models of RTHβ is consistent with a skeletal phenotype of accelerated bone development in juveniles and increased bone turnover with osteoporosis in adults.
“Nevertheless, analysis of the skeletal consequences of mutations of Thrb in mouse models of RTHβ is consistent with a skeletal phenotype of accelerated bone development in juveniles and increased bone turnover with osteoporosis in adults that is due to increased T3 action in cartilage and bone [1, 83, 89–91].”
From Thyroid diseases and bone health (2018) · cites this paper as [90]
In “Resistance to thyroid hormone and mouse models” (page unavailable), the paper reports advanced ossification in TRβPV mice and increased skeletal T3 signaling, supporting accelerated bone development. It does not report increased bone turnover or osteoporosis in adult mutant mice; its mention of osteoporosis in “Implications of skeletal observations” concerns potential treatments. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe skeletal phenotype in mouse models of RTHβ is due to increased T3 action in cartilage and bone.
“Nevertheless, analysis of the skeletal consequences of mutations of Thrb in mouse models of RTHβ is consistent with a skeletal phenotype of accelerated bone development in juveniles and increased bone turnover with osteoporosis in adults that is due to increased T3 action in cartilage and bone [1, 83, 89–91].”
From Thyroid diseases and bone health (2018) · cites this paper as [90]
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Cited by
Sorted by citations
Role of Thyroid Hormones in Skeletal Development and Bone Maintenance
Bassett, J. H. D., & Williams, G. R. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1106 · Cited by 540 · see citing works
Self-citationThyroid diseases and bone health
Williams, G. R., & Bassett, J. H. D. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0753-4 · Cited by 276 · see citing works
Self-citationBassett, J. H. D., Boyde, A., Zikmund, T., Evans, H., Croucher, P. I., Zhu, X., Park, J. W., Cheng, S.-Y., & Williams, G. R. (2014) · Endocrinology · doi:10.1210/en.2013-2156 · Cited by 50 · see citing works
Self-citationO’Shea, P. J., Guigon, C. J., Williams, G. R., & Cheng, S.-Y. (2007) · Endocrinology · doi:10.1210/en.2007-0114 · Cited by 22 · see citing works
Self-citation
- Authors
- O'Shea, P. J., Bassett, J. H. D., Cheng, S.-Y., & Williams, G. R.
- Affiliations
- National Institutes of Health (US)
- Imperial College London (GB)
- Corresponding author
- Williams, Graham R.
- Venue
- Nuclear Receptor Signaling
- Publisher
- SAGE Publications
- Published
- 2006-01
- Volume
- 4
- Issue
- 1
- Pages
- e011-e011
- ISSN
- 1550-7629 (ISSN-L)
- PMC
- PMC1513065
- OpenAlex
- W2031397263
- Cited by
- 53
- References
- 2
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 7
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nuclear Receptor Signaling (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- thyroid hormone receptor alpha 1, thyroid hormone receptor beta, skeletal phenotype, skeletal development, thyroid function, tissue-specific gene expression, mouse mutants
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