The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Primary Differentiation in the Human Blastocyst: Comparative Molecular Portraits of Inner Cell Mass and Trophectoderm Cells
Open accessAbstract
The primary differentiation event during mammalian development occurs at the blastocyst stage and leads to the delineation of the inner cell mass (ICM) and the trophectoderm (TE). We provide the first global mRNA expression data from immunosurgically dissected ICM cells, TE cells, and intact human blastocysts. Using a cDNA microarray composed of 15,529 cDNAs from known and novel genes, we identify marker transcripts specific to the ICM (e.g., OCT4/POU5F1, NANOG, HMGB1, and DPPA5) and TE (e.g., CDX2, ATP1B3, SFN, and IPL), in addition to novel ICM- and TE-specific expressed sequence tags. The expression patterns suggest that the emergence of pluripotent ICM and TE cell lineages from the morula is controlled by metabolic and signaling pathways, which include inter alia, WNT, mitogen-activated protein kinase, transforming growth factor-beta, NOTCH, integrin-mediated cell adhesion, phosphatidylinositol 3-kinase, and apoptosis. These data enhance our understanding of the first step in human cellular differentiation and, hence, the derivation of both embryonic stem cells and trophoblastic stem cells from these lineages.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kahlem, P., Sultan, M., Herwig, R., Steinfath, M., Balzereit, D., Eppens, B., Saran, N. G., Pletcher, M. T., South, S. T., Stetten, G., et al. (2004) · Genome Research · doi:10.1101/gr.1951304 · Cited by 249
Self-citation
Cited by
Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.05.001 · Cited by 956
Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA
Kamburov, A., Cavill, R., Ebbels, T. M. D., Herwig, R., & Keun, H. C. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr499 · Cited by 403
Self-citationMaking the blastocyst: lessons from the mouse
Cockburn, K., & Rossant, J. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41229 · Cited by 391
Human skin stem cells and the ageing process
Zouboulis, C. C., Adjaye, J., Akamatsu, H., Moe-Behrens, G., & Niemann, C. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.09.001 · Cited by 176
Self-citationExpression profiling of drug response - from genes to pathways
Herwig, R., & Lehrach, H. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.3/rherwig · Cited by 14
Self-citation
Metadata
- Authors
- Adjaye, J., Huntriss, J., Herwig, R., BenKahla, A., Brink, T. C., Wierling, C., Hultschig, C., Groth, D., Yaspo, M., Picton, H. M., Gosden, R. G., & Lehrach, H.
- Venue
- STEM CELLS
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11
- Volume
- 23
- Issue
- 10
- Pages
- 1514-1525
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2113424612
- Cited by
- 213
- References
- 1
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Primary Differentiation in the Human Blastocyst: Comparative Molecular Portraits of Inner Cell Mass and Trophectoderm Cells. https://app.cochat.ai/papers/10.1634/stemcells.2005-0113
- The paper
- Adjaye, J., Huntriss, J., Herwig, R., BenKahla, A., Brink, T. C., Wierling, C., Hultschig, C., Groth, D., Yaspo, M., Picton, H. M., Gosden, R. G., & Lehrach, H. (2005). Primary Differentiation in the Human Blastocyst: Comparative Molecular Portraits of Inner Cell Mass and Trophectoderm Cells. STEM CELLS. https://doi.org/10.1634/stemcells.2005-0113
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
