The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Accumulated Chromosomal Instability in Murine Bone Marrow Mesenchymal Stem Cells Leads to Malignant Transformation
Open accessAbstract
Despite recent emerging evidence suggesting that cancer stem cells subsist in a variety of tumors, it is not yet fully elucidated whether postnatal stem cells are directly involved in tumorigenesis. We used murine bone marrow–derived mesenchymal stem cells (BMMSCs) as a model to test a hypothesis that tumorigenesis may originate from spontaneous mutation of stem cells. In this study, we demonstrated that murine BMMSCs, after numerous passages, obtained unlimited population doublings and proceeded to a malignant transformation state, resulting in fibrosarcoma formation in vivo. Transformed BMMSCs colonized to multiple organs when delivered systemically through the tail vein. Fibrosarcoma cells formed by transformed BMMSCs contained cancer progenitors, which were capable of generating colony clusters in vitro and fibrosarcoma in vivo by the second administration. The mechanism by which BMMSCs transformed to malignant cells was associated with accumulated chromosomal abnormalities, gradual elevation in telomerase activity, and increased c-myc expression. Moreover, BMMSCs and their transformed counterpart, fibrosarcoma-forming cells, demonstrated different sensitivity to anti-cancer drugs. BMMSCs/fibrosarcoma transformation system may provide an ideal system to elucidate the mechanism of how stem cells become cancer cells and to screen anti-sarcoma drugs.
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2 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,518
RetractedSpontaneous Human Adult Stem Cell Transformation
Rubio, D., Garcia-Castro, J., Martín, M. C., de la Fuente, R., Cigudosa, J. C., Lloyd, A. C., & Bernad, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4194 · Cited by 1,036
RetractedMultilineage potential of adult human mesenchymal stem cells
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Prospective identification of tumorigenic breast cancer cells
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Identification of human brain tumour initiating cells
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Self-citation
Cited by
Mesenchymal Stromal Cells: Current Understanding and Clinical Status
Salem, H. K., & Thiemermann, C. (2010) · Stem Cells · doi:10.1002/stem.269 · Cited by 915
Bone Marrow Mesenchymal Stem Cells: Historical Overview and Concepts
Charbord, P. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.115 · Cited by 441
Tarte, K., Gaillard, J., Lataillade, J.-J., Fouillard, L., Becker, M., Mossafa, H., Tchirkov, A., Rouard, H., Henry, C., Splingard, M., et al. (2010) · Blood · doi:10.1182/blood-2009-05-219907 · Cited by 430
J. Centeno, C., R. Schultz, J., Cheever, M., Freeman, M., Faulkner, S., Robinson, B., & Hanson, R. (2011) · Current Stem Cell Research & Therapy · doi:10.2174/157488811797904371 · Cited by 234
Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury
Hu, C., Zhao, L., Zhang, L., Bao, Q., & Li, L. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01895-1 · Cited by 130
Metadata
- Authors
- Miura, M., Miura, Y., Padilla-Nash, H. M., Molinolo, A. A., Fu, B., Patel, V., Seo, B.-M., Sonoyama, W., Zheng, J. J., Baker, C. C., Chen, W., Ried, T., & Shi, S.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-04-01
- Volume
- 24
- Issue
- 4
- Pages
- 1095-1103
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2013353419
- Cited by
- 567
- References
- 31
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Miura, M., Miura, Y., Padilla-Nash, H. M., Molinolo, A. A., Fu, B., Patel, V., Seo, B.-M., Sonoyama, W., Zheng, J. J., Baker, C. C., Chen, W., Ried, T., & Shi, S. (2006). Accumulated Chromosomal Instability in Murine Bone Marrow Mesenchymal Stem Cells Leads to Malignant Transformation. Stem Cells. https://doi.org/10.1634/stemcells.2005-0403
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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