Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury
Open accessAbstract
Various hepatoxic factors, such as viruses, drugs, lipid deposition, and autoimmune responses, induce acute or chronic liver injury, and 3.5% of all worldwide deaths result from liver cirrhosis, liver failure, or hepatocellular carcinoma. Liver transplantation is currently limited by few liver donors, expensive surgical costs, and severe immune rejection. Cell therapy, including hepatocyte transplantation and stem cell transplantation, has recently become an attractive option to reduce the overall need for liver transplantation and reduce the wait time for patients. Recent studies showed that mesenchymal stem cell (MSC) administration was a promising therapeutic approach for promoting liver regeneration and repairing liver injury by the migration of cells into liver sites, hepatogenic differentiation, immunoregulation, and paracrine mechanisms. MSCs secrete a large number of molecules into the extracellular space, and soluble proteins, free nucleic acids, lipids, and extracellular vesicles (EVs) effectively repair tissue injury in response to fluctuations in physiological states or pathological conditions. Cell-free-based therapies avoid the potential tumorigenicity, rejection of cells, emboli formation, undesired differentiation, and infection transmission of MSC transplantation. In this review, we focus on the potential mechanisms of MSC-based cell-free strategies for attenuating liver injury in various liver diseases. Secretome-mediated paracrine effects participate in the regulation of the hepatic immune microenvironment and promotion of hepatic epithelial repair. We look forward to completely reversing liver injury through an MSC-based cell-free strategy in regenerative medicine in the near future.
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MSCs can differentiate into hepatocyte-like cells.
“newer research has determined their phenomenal plasticity, including their potency to differentiate into hepatocyte-like cells (HLCs)([39, 40]”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [40]
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Self-citation
- Authors
- Hu, C., Zhao, L., Zhang, L., Bao, Q., & Li, L.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Corresponding author
- Li, Lanjuan
- Venue
- Stem Cell Research & Therapy
- Published
- 2020-09-03
- Volume
- 11
- Issue
- 1
- Pages
- 377-377
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC7469278
- OpenAlex
- W3082320282
- Cited by
- 130
- References
- 103
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 23 · 2023: 35 · 2022: 28 · 2021: 15
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81700553)
- Zhejiang basic public welfare research program (LGF20H030008)
- Independent Fund of State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University (N/A)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- mesenchymal stem cells, cell-free therapy, liver injury, liver regeneration, extracellular vesicles, secretome, paracrine signaling, hepatocyte transplantation, liver transplantation alternatives, liver cirrhosis, liver failure, hepatocellular carcinoma, immune regulation, hepatic immune microenvironment, hepatocyte differentiation
- MeSH terms
- Extracellular Vesicles, Humans, Liver Diseases, Liver Regeneration, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells
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