The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Electrical Stimulation Modulates Fate Determination of Differentiating Embryonic Stem Cells
Abstract
A clear understanding of cell fate regulation during differentiation is key in successfully using stem cells for therapeutic applications. Here, we report that mild electrical stimulation strongly influences embryonic stem cells to assume a neuronal fate. Although the resulting neuronal cells showed no sign of specific terminal differentiation in culture, they showed potential to differentiate into various types of neurons in vivo, and, in adult mice, contributed to the injured spinal cord as neuronal cells. Induction of calcium ion influx is significant in this differentiation system. This phenomenon opens up possibilities for understanding novel mechanisms underlying cellular differentiation and early development, and, perhaps more importantly, suggests possibilities for treatments in medical contexts.
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Citations
Cites
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003) · Nature Biotechnology · doi:10.1038/nbt780 · Cited by 1,504
Kühl, M., Sheldahl, L. C., Malbon, C. C., & Moon, R. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12701 · Cited by 517
Cited by
Ghasemi-Mobarakeh, L., Prabhakaran, M. P., Morshed, M., Nasr-Esfahani, M. H., Baharvand, H., Kiani, S., Al-Deyab, S. S., & Ramakrishna, S. (2011) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.383 · Cited by 698
Liu, Z., Wan, X., Wang, Z. L., & Li, L. (2021) · Advanced Materials · doi:10.1002/adma.202007429 · Cited by 478
Electromagnetic effects—From cell biology to medicine
Funk, R. H. W., Monsees, T., & Özkucur, N. (2009) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2008.07.001 · Cited by 423
Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells
Nakamura, M., & Okano, H. (2013) · Cell Research · doi:10.1038/cr.2012.171 · Cited by 214
Self-citationCombining Topographical and Genetic Cues to Promote Neuronal Fate Specification in Stem Cells
Purcell, E. K., Naim, Y., Yang, A., Leach, M. K., Velkey, J. M., Duncan, R. K., & Corey, J. M. (2012) · Biomacromolecules · doi:10.1021/bm301220k · Cited by 26
Metadata
- Authors
- Yamada, M., Tanemura, K., Okada, S., Iwanami, A., Nakamura, M., Mizuno, H., Ozawa, M., Ohyama-Goto, R., Kitamura, N., Kawano, M., Tan-Takeuchi, K., Ohtsuka, C., Miyawaki, A., Takashima, A., Ogawa, M., Toyama, Y., Okano, H., & Kondo, T.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11-16
- Volume
- 25
- Issue
- 3
- Pages
- 562-570
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2140715956
- Cited by
- 189
- References
- 2
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
