The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Isolation and Characterization of Pluripotent Human Spermatogonial Stem Cell-Derived Cells
Open accessAbstract
Several reports have documented the derivation of pluripotent cells (multipotent germline stem cells) from spermatogonial stem cells obtained from the adult mouse testis. These spermatogonia-derived stem cells express embryonic stem cell markers and differentiate to the three primary germ layers, as well as the germline. Data indicate that derivation may involve reprogramming of endogenous spermatogonia in culture. Here, we report the derivation of human multipotent germline stem cells (hMGSCs) from a testis biopsy. The cells express distinct markers of pluripotency, form embryoid bodies that contain derivatives of all three germ layers, maintain a normal XY karyotype, are hypomethylated at the H19 locus, and express high levels of telomerase. Teratoma assays indicate the presence of human cells 8 weeks post-transplantation but limited teratoma formation. Thus, these data suggest the potential to derive pluripotent cells from human testis biopsies but indicate a need for novel strategies to optimize hMGSC culture conditions and reprogramming.
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Cites
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1×
“In immortal cells, such as hESCs, germ cells, or cancer cells, the shortening of telomere length is prevented by telomerase [56–58].”
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Cited by
LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
Nguyen, H. N., Byers, B., Cord, B., Shcheglovitov, A., Byrne, J., Gujar, P., Kee, K., Schüle, B., Dolmetsch, R. E., Langston, W., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.01.013 · Cited by 745
Self-citationPropagation of Human Spermatogonial Stem Cells In Vitro
Sadri-Ardekani, H. (2009) · JAMA · doi:10.1001/jama.2009.1689 · Cited by 375
Isolation, Characterization, and Culture of Human Spermatogonia1
He, Z., Kokkinaki, M., Jiang, J., Dobrinski, I., & Dym, M. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.109.078550 · Cited by 317
Metadata
- Authors
- Kossack, N., Meneses, J., Shefi, S., Nguyen, H. N., Chavez, S., Nicholas, C., Gromoll, J., Turek, P. J., & Reijo-Pera, R. A.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01-01
- Volume
- 27
- Issue
- 1
- Pages
- 138-149
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2027011084
- Cited by
- 281
- References
- 3
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kossack, N., Meneses, J., Shefi, S., Nguyen, H. N., Chavez, S., Nicholas, C., Gromoll, J., Turek, P. J., & Reijo-Pera, R. A. (2009). Isolation and Characterization of Pluripotent Human Spermatogonial Stem Cell-Derived Cells. Stem Cells. https://doi.org/10.1634/stemcells.2008-0439
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