The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Therapy for Metastatic Colorectal Cancer
Open accessAbstract
Learning Objectives: After completing this course, the reader will be able to: Compare toxicity profiles among combination chemotherapy programs for colorectal cancer.Identify median survival times for chemotherapy programs for colorectal cancer.Discuss the new Intergroup trial schema and the rationale behind the study. Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
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FOLFIRI or FOLFOX can significantly extend the median OS to >15 months.
“Although FOLFIRI or FOLFOX can significantly extend the median OS to >15 months, there are nearly 50% patients are not responsive38.”
From A tumor microenvironment-specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients (2021) · cites this paper as [38]
Nearly 50% of patients are not responsive to FOLFIRI or FOLFOX.
“Although FOLFIRI or FOLFOX can significantly extend the median OS to >15 months, there are nearly 50% patients are not responsive38.”
From A tumor microenvironment-specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients (2021) · cites this paper as [38]
Citations
Cites
Cunningham, D., Humblet, Y., Siena, S., Khayat, D., Bleiberg, H., Santoro, A., Bets, D., Mueser, M., Harstrick, A., Verslype, C., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033025 · Cited by 5,035
Tournigand, C., André, T., Achille, E., Lledo, G., Flesh, M., Mery-Mignard, D., Quinaux, E., Couteau, C., Buyse, M., Ganem, G., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.113 · Cited by 2,915
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Research works printed but not linked: 34
- Kelly, 2005, Systemic therapy for metastatic colorectal cancer: current options, current evidence, J Clin Oncol, 23, 4553, 10.1200/JCO.2005.17.749 · DOI
- Grothey, 2004, Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment, J Clin Oncol, 22, 1209, 10.1200/JCO.2004.11.037 · DOI · Paper page
- Douillard, 2000, Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial, Lancet, 355, 1041, 10.1016/S0140-6736(00)02034-1 · DOI · Paper page
- de Gramont, 1997, Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study, J Clin Oncol, 15, 808, 10.1200/JCO.1997.15.2.808 · DOI
- Goldberg, 2004, A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer, J Clin Oncol, 22, 23, 10.1200/JCO.2004.09.046 · DOI
- Hurwitz, 2005, Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer, J Clin Oncol, 23, 3502, 10.1200/JCO.2005.10.017 · DOI
- Kabbinavar, 2005, Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer, J Clin Oncol, 23, 3706, 10.1200/JCO.2005.00.232 · DOI · Paper page
- Maughan, Fluorouracil (FU), oxaliplatin (Ox), CPT-11 (irinotecan, Ir), use and sequencing, in advanced colorectal cancer (ACRC): the UK MRC FOCUS (CR08) trial. 2005 Gastrointestinal Cancers Symposium: 165a
- Seymour, Fluorouracil, oxaliplatin and CPT-11 (irinotecan), use and sequencing (MRC FOCUS): a 2135-patient randomized trial in advanced colorectal cancer (ACRC). 2005 ASCO Annual Meeting: 3518a
- D'Andre, 2005, 5-Fluorouracil-based chemotherapy for advanced colorectal cancer in elderly patients: a North Central Cancer Treatment Group study, Clin Colorectal Cancer, 4, 325, 10.3816/CCC.2005.n.005 · DOI
- De Gramont, OPTIMOX study: FOLFOX 7/LV5FU2 compared to FOLFOX 4 in patients with advanced colorectal cancer, J Clin Oncol 2004 ASCO Annual Meeting Proceedings (Post-Meeting Ed.), 22, 3525
- Tournigand, 5-Fluorouracil, folinic acid and oxaliplatin (FOLFOX) in poor prognosis patients with metastatic colorectal cancer, J Clin Oncol 2004 ASCO Annual Meeting Proceedings (Post-Meeting Ed.), 22, 3565
- de Gramont, 1997, [Modulation of 5-fluorouracil with folinic acid in advanced colorectal cancers, Rev Med Interne, 18, 372s, 10.1016/S0248-8663(97)83768-X · DOI
- Kohne, 2003, Randomized phase III study of high-dose fluorouracil given as a weekly 24-hour infusion with or without leucovorin versus bolus fluorouracil plus leucovorin in advanced colorectal cancer: European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952, J Clin Oncol, 21, 3721, 10.1200/JCO.2003.11.122 · DOI
- Hoff, 2001, The evolution of fluoropyrimidine therapy: from intravenous to oral, The Oncologist, 6, 3, 10.1634/theoncologist.6-suppl_4-3 · DOI
- Van Cutsem, 2001, Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with meta-static colorectal cancer: results of a large phase III study, J Clin Oncol, 19, 4097, 10.1200/JCO.2001.19.21.4097 · DOI
- Goldberg, 2002, Early detection of toxicity and adjustment of ongoing clinical trials: the history and performance of the North Central Cancer Treatment Group's real-time toxicity monitoring program, J Clin Oncol, 20, 4591, 10.1200/JCO.2002.03.039 · DOI
- Delaunoit, 2004, Mortality associated with daily bolus 5-fluorouracil/leucovorin administered in combination with either irinotecan or oxaliplatin: results from Intergroup Trial N9741, Cancer, 101, 2170, 10.1002/cncr.20594 · DOI
- Schmoll, 2006, Update on capecitabine in colorectal cancer, The Oncologist, 11, 1003, 10.1634/theoncologist.11-9-1003 · DOI
- Reddy, 2005, Evolution of FOLFOX regimens in the treatment of advanced colorectal cancer, Clin Colorectal Cancer, 4, 296, 10.1016/S1533-0028(11)70130-X · DOI
- de Gramont, 2000, Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer, J Clin Oncol, 18, 2938, 10.1200/JCO.2000.18.16.2938 · DOI · Paper page
- Colucci, 2005, Phase III randomized trial of FOL-FIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell'Italia Meridionale, J Clin Oncol, 23, 4866, 10.1200/JCO.2005.07.113 · DOI
- Hurwitz, 2004, Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer, N Engl J Med, 350, 2335, 10.1056/NEJMoa032691 · DOI · Paper page
- Hurwitz, 2004, Integrating the anti-VEGF-A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer, Clin Colorectal Cancer, 4, S62, 10.3816/CCC.2004.s.010 · DOI
- Fernando, 2004, Targeted therapy of colorectal cancer: clinical experience with bevacizumab, The Oncologist, 9, 11, 10.1634/theoncologist.9-suppl_1-11 · DOI
- Tyagi, 2005, Vatalanib (PTK787/ZK 222584) in combination with FOLFOX4 versus FOLFOX4 alone as first-line treatment for colorectal cancer: preliminary results from the CONFIRM-1 trial, Clin Colorectal Cancer, 5, 24, 10.1016/S1533-0028(11)70162-1 · DOI
- Giantonio, 2005, High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: results from the Eastern Cooperative Oncology Group (ECOG) study E3200, Proc Am Soc Clin Oncol, 24, 2a, 10.1200/jco.2005.23.16_suppl.2 · DOI
- Erlichman, 2004, New treatment options for colorectal cancer, N Engl J Med, 351, 391, 10.1056/NEJMe048151 · DOI
- Saltz, Interim report of randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer
- Saltz, 2005, Randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer, Proc Am Soc Clin Oncol, 24, 3508a, 10.1200/jco.2005.23.16_suppl.3508 · DOI
- Hecht, 2005, A randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic adeno-carcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1), Proc Am Soc Clin Oncol, 24, 3a, 10.1200/jco.2005.23.16_suppl.lba3 · DOI
- Tabernero, An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR). Preliminary results, J Clin Oncol 2004 ASCO Annual Meeting Proceedings (Post-Meeting Ed.), 22, 3512a
- Fisher, A phase II study of gefitinib in combination with FOLFOX-4 (IFOX) in patients with metastatic colorectal cancer, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Ed.), 22, 3514a
- Zampino, First-line gefitinib combined with simplified FOLFOX-6 in patients with epidermal growth factor receptor-positive advanced colorectal cancer, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Ed.), 22, 3659a
Cited by
Sorted by citations
Zhu, X., Tian, X., Ji, L., Zhang, X., Cao, Y., Shen, C., Hu, Y., Wong, J. W. H., Fang, J.-Y., Hong, J., et al. (2021) · npj Precision Oncology · doi:10.1038/s41698-021-00142-x · Cited by 41
Metadata
- Authors
- Goldberg, R. M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Goldberg, Richard M.
- ORCID
- Goldberg, Richard M.
- Venue
- The Oncologist
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-01
- Volume
- 11
- Issue
- 9
- Pages
- 981-987
- ISSN
- 1083-7159 (ISSN-L)
- 1549-490X
- OpenAlex
- W2152740887
- Cited by
- 78
- References
- 2
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Oncologist (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Keywords
- metastatic colorectal cancer, combination chemotherapy, oxaliplatin, anti-VEGF antibody, anti-EGFR monoclonal antibody, biologic therapy, chemotherapy sequencing, overall survival, curative resection
- MeSH terms
- Antineoplastic Combined Chemotherapy Protocols, Clinical Trials as Topic, Humans, Neoplasm Metastasis, Colorectal Neoplasms
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