Cited by 482Effects of Radiation ExposureRadiation Therapy and DosimetryChemotherapy-induced organ toxicity mitigation

Radioprotectors and mitigators of radiation-induced normal tissue injury

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Citrin, Deborah, Cotrim, Ana P., Hyodo, Fuminori, Baum, Bruce J., Krishna, Murali C., Mitchell, James B.·2010·The Oncologist

Abstract

Radiation is used in the treatment of a broad range of malignancies. Exposure of normal tissue to radiation may result in both acute and chronic toxicities that can result in an inability to deliver the intended therapy, a range of symptoms, and a decrease in quality of life. Radioprotectors are compounds that are designed to reduce the damage in normal tissues caused by radiation. These compounds are often antioxidants and must be present before or at the time of radiation for effectiveness. Other agents, termed mitigators, may be used to minimize toxicity even after radiation has been delivered. Herein, we review agents in clinical use or in development as radioprotectors and mitigators of radiation-induced normal tissue injury. Few agents are approved for clinical use, but many new compounds show promising results in preclinical testing.

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Crossref · 10.1634/theoncologist.2009-s104

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  • Interventional strategies reducing the deleterious effect of radiation on normal epithelia and preserving the integrity of the oral mucosa will have a great impact on the quality of life of cancer patients.

    “interventional strategies reducing the deleterious effect of radiation on normal epithelia and hence preserving the integrity of the oral mucosa will have a great impact in the quality of life of cancer patients (Citrin et al., 2010).”

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Authors
Citrin, D., Cotrim, A. P., Hyodo, F., Baum, B. J., Krishna, M. C., & Mitchell, J. B.
Affiliations
  • National Cancer Institute (US)
  • National Institutes of Health (US)
Corresponding author
Citrin, Deborah
Venue
The Oncologist
Published
2010-03-12
Volume
15
Issue
4
Pages
360-371
ISSN
  • 1083-7159 (ISSN-L)
  • 1549-490X
OpenAlex
W2109827369
Cited by
482
References
93
Citations by year
2026: 9 · 2025: 29 · 2024: 21 · 2023: 33 · 2022: 36 · 2021: 33 · 2020: 28 · 2019: 45 · 2018: 33 · 2017: 31 · 2016: 35 · 2015: 35 · 2014: 27 · 2013: 37 · 2012: 31
FWCI
4.04
Type
journal article
Language
en
Open access
Locations
  • The Oncologist (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Research Program of the Center for Cancer Research
  • National Cancer Institute
  • National Institutes of Health
  • Division of Intramural Research
  • National Institute of Dental and Craniofacial Research
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
Keywords
radioprotective agents, radiation toxicity, antioxidants, radiotherapy complications, acute and chronic toxicity
MeSH terms
Animals, Antioxidants, Cyclic N-Oxides, DNA Damage, Amifostine, Humans, Magnetic Resonance Imaging, Neoplasms, Radiation Injuries, Radiation Protection, Radiation-Protective Agents, Risk Factors, Spin Labels, Free Radical Scavengers, Fibroblast Growth Factor 7

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