The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions
Open accessAbstract
The use of immune checkpoint inhibitors (ICIs) has become one of the most promising approaches in the field of cancer therapy. Unlike the current therapies that target tumor cells, such as chemotherapy, radiotherapy, or targeted therapy, ICIs directly restore the exhausted host antitumor immune responses mediated by the tumors. Among multiple immune modulators identified, the programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) axis leading to the exhaustion of T-cell immunity in chronic infections and tumors has been widely investigated. Therefore, blocking antibodies targeting PD-1 or PD-L1 have been developed and approved for the treatment of various advanced cancers, including non-small-cell lung cancer (NSCLC), making them the most successful ICIs. Compared with chemotherapy or radiotherapy, PD-1/PD-L1 blockade therapy significantly improves the durable response rate and prolongs long-term survival with limited adverse effects in both monotherapy and combination therapy for advanced NSCLC. However, extensive challenges exist for further clinical applications, such as a small fraction of benefit population, primary and acquired resistance, the lack of predictive and prognostic biomarkers, and treatment-related adverse effects. In this article, we summarize the latest clinical applications of PD-1/PD-L1 blockade therapy in advanced NSCLC worldwide, as well as in China, and discuss the bottlenecks related to the use of this therapy in clinical practice. An exploration of the underlying mechanism of PD-1/PD-L1 blockade therapy and biomarker identification will maximize the application of ICIs in advanced NSCLC and facilitate bedside-to-bench studies in cancer immunotherapy as well.
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Cites
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
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Cancer statistics in China, 2015
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Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
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“The antitumor efficacy of these ICIs observed in clinical trials is also encouraging for multiple advanced cancers [7, 32].”
Background
Cited by
The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers
Tang, Q., Chen, Y., Li, X., Long, S., Shi, Y., Yu, Y., Wu, W., Han, L., & Wang, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.964442 · Cited by 561
Zhuo, N., Liu, C., Zhang, Q., Li, J., Zhang, X., Gong, J., Lu, M., Peng, Z., Zhou, J., Wang, X., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.4637 · Cited by 30
Self-citationLin, Y., Chen, M., Huang, S., Chen, Y., Ho, J. H., Lin, F., Tan, X., Chiang, H., Huang, C., Tu, C., et al. (2024) · Advanced Science · doi:10.1002/advs.202309697 · Cited by 24
New advances in the study of PD-1/PD-L1 inhibitors-induced liver injury
Yue, M., Li, C., & Li, G. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111799 · Cited by 12
Metadata
- Authors
- Xia, L., Liu, Y., & Wang, Y.
- Venue
- The Oncologist
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-02-01
- Volume
- 24
- Issue
- S1
- Pages
- S31-S41
- ISSN
- 1083-7159 (ISSN-L)
- 1549-490X
- OpenAlex
- W2918948206
- Cited by
- 394
- References
- 123
- FWCI
- 15.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Xia, L., Liu, Y., & Wang, Y. (2019). PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions. The Oncologist. https://doi.org/10.1634/theoncologist.2019-io-s1-s05
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
