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Cited by 254Phytochemistry Medicinal Plant ApplicationsEthnobotanical and Medicinal Plants StudiesPhytochemical Studies and Bioactivities

Anti-cancer drug discovery and development in Brazil: Targeted plant collection as a rational strategy to acquire candidate anti-cancer compounds

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Mans, Dennis R.A., Rocha, Adriana B., Schwartsmann, Gilberto·2000·The Oncologist
DOI 10.1634/theoncologist.5-3-185
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Abstract

Throughout medical history, plant products have been shown to be valuable sources of novel anti-cancer drugs. Examples are the Vinca alkaloids, the taxanes, and the camptothecins, derived from the Madagscan periwinkle plant Catharantus roseus, the Pacific yew Taxus brevifolia, and the Chinese tree Camptotheca acuminata, respectively. For this reason, the South-American Office for Anti-Cancer Drug Development has implemented a large-scale project of acquisition and testing of compounds isolated from South American medicinal plants. The species are selected on the basis of a potentially useful phytochemical composition by consulting ethnopharmacological, chemosystemic, and ecological information. The collected samples are dried and first extracted with an organic solvent, then with distilled water. These crude extracts are evaluated at a concentration of 50 μg/ml for antiproliferative activity against one cell line. Extracts that significantly inhibit the growth of the cells (≥50%) at relatively low concentrations (≤50 μg/ml) are submitted to the more comprehensive disease-oriented screen of the U.S. National Cancer Institute. In parallel, these samples are further purified by bioassay-guided purification, involving repeated fractionation by diverse chromatography methods. If the active substance is expected to represent a novel structure, it is identified by appropriate chemical techniques, mechanistic studies are performed with a wide diversity of tumor models and laboratory techniques, and efforts are undertaken for the synthesis of potentially more useful analogs.

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Authors
Mans, D. R. A., Rocha, A. B., & Schwartsmann, G.
Affiliations
Universidade Luterana do Brasil (BR)
Corresponding author
Schwartsmann, Gilberto
ORCID
Venue
The Oncologist
Publisher
Oxford University Press (OUP)
Published
2000-06-01
Volume
5
Issue
3
Pages
185-198
ISSN
  • 1083-7159 (ISSN-L)
  • 1549-490X
DOI
10.1634/theoncologist.5-3-185
OpenAlex
W2077904082
Cited by
254
References
121
Citations by year
2025: 4 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 16 · 2020: 12 · 2019: 7 · 2018: 15 · 2017: 15 · 2016: 12 · 2015: 17 · 2014: 12 · 2013: 20 · 2012: 18
FWCI
7.29
Type
journal article
Language
en
Open access
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • The Oncologist (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Ethnobotanical and Medicinal Plants Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
Keywords
anticancer drug discovery, medicinal plants, antiproliferative activity, bioassay-guided fractionation, natural product isolation, ethnopharmacology, antitumor alkaloids, taxanes, camptothecin, Brazil
MeSH terms
Antineoplastic Agents, Phytogenic, Brazil, Conservation of Natural Resources, Drug Screening Assays, Antitumor, Humans, Plants, Medicinal, Ethnopharmacology

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