Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 15Effects of Radiation ExposureHematopoietic Stem Cell TransplantationNeutropenia and Cancer Infections

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Hematopoietic Recovery using Multi-Cytokine Therapy in 8 Patients Presenting Radiation-Induced Myelosuppression after Radiological Accidents

Benderitter, Marc, Herrera-Reyes, Eduardo, Gigov, Yvan, Souleau, Bertrand, Huet, Christelle, Trompier, François, Fagot, Thierry, Grégoire, Eric, Malfuson, Jean Valère, Konopacki-Potet, Johanna, Buglova, Elena, Lataillade, Jean-Jacques, Tamarat, Radia, Gourmelon, Patrick, de Revel, Thierry·2021·Radiation Research
DOI 10.1667/rade-21-00169.1
Open this paper in CoChat — free account

Abstract

Treatment of accidental radiation-induced myelosuppression is primarily based on supportive care and requires specific treatment based on hematopoietic growth factors injection or hematopoietic cell transplantation for the most severe cases. The cytokines used consisted of pegylated erythropoietin (darbepoetin alfa) 500 IU once per week, pegylated G-CSF (pegfilgrastim) 6 mg × 2 once, stem cell factor 20 µg.kg-1 for five days, and romiplostim (TPO analog) 10 µg.kg -1 once per week, with different combinations depending on the accidents. As the stem cell factor did not have regulatory approval for clinical use in France, the French regulatory authorities (ANSM, formerly, AFSSAPS) approved their compassionate use as an investigational drug "on a case-by-case basis". According to the evolution and clinical characteristics, each patient's treatment was adopted on an individual basis. Daily blood count allows initiating G-CSF and SCF delivery when granulocyte <1,000/mm3, TPO delivery when platelets <50,000/mm3, and EPO when Hb<80 g/L. The length of each treatment was based on blood cell recovery criteria. The concept of "stimulation strategy" is linked to each patient's residual hematopoiesis, which varies among them, depending on the radiation exposure's characteristics and heterogeneity. This paper reports the medical management of 8 overexposed patients to ionizing radiation. The recovery of bone marrow function after myelosuppression was accelerated using growth factors, optimi…

Overview

Integrity signals

Registry

Crossref · 10.1667/rade-21-00169.1

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 57 references

Research works printed but not linked: 3

  1. AM El-Naggar, MH Mohammad, MA Gomaa, "The Medical Basis for Nuclear Accident Preparedness. The Clinical Care of Victims. Proceedings of the Fourth International REAC/TS Conference on the Medical Basis for Radiation-Accident Preparedness (held March 6-8, 2001, in Orlando, Florida)." "The radiological accident at Meet Halfa, Qaluobiya, Egypt." 316 (2002)
  2. V. Jinaratana, "The medical basis for radiation-accidents preparedness. The Clinical care of victims proceeding of the fourth international REAC/TS conference on the medical basis for radiation accidents preparedness (held March 6-8, 2001, in Orlando, Florida)." "The radiological accident in Thailand." 283 (2002)
  3. T MacVittie and A Faresse "The medical basis for radiation-accidents preparedness the clinical care of victims proceeding of the fourth international REAC/TS conference on the medical basis for radiation accidents preparedness (held March 6-8, 2001, in Orlando, Florida)." "Cytokine-based treatment for acute radiation-induced myelosuppression: preclinical and clinical perspective." 53 (2002)

Cited by

See all 15

Related

See all

Metadata

Authors
Benderitter, M., Herrera-Reyes, E., Gigov, Y., Souleau, B., Huet, C., Trompier, F., Fagot, T., Grégoire, E., Malfuson, J. V., Konopacki-Potet, J., Buglova, E., Lataillade, J.-J., Tamarat, R., Gourmelon, P., & de Revel, T.
Affiliations
  • Institut de Radioprotection et de Sûreté Nucléaire (FR)
  • Military Hospital, Department of Hematology and Chemotherapy for Solid Tumors, Sofia, Bulgaria
  • Hôpital d'instruction des Armées Percy (FR)
  • International Atomic Energy Agency (AT)
  • Ecole du Val de Grâce, 75005 Paris, France
Corresponding author
Benderitter, Marc
ORCID
Venue
Radiation Research
Publisher
Radiation Research Society
Published
2021-09-23
Volume
196
Issue
6
Pages
668-679
ISSN
  • 0033-7587 (ISSN-L)
  • 1938-5404
DOI
10.1667/rade-21-00169.1
OpenAlex
W3201501110
Cited by
15
References
57
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4
FWCI
1.33
Type
journal article
Language
en
Open access
closed
Locations
  • Radiation Research (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Keywords
radiation-induced myelosuppression, hematopoietic recovery, pegfilgrastim, darbepoetin alfa, romiplostim, stem cell factor, radiation accidents, hematopoietic growth factors, compassionate use, bone marrow function
MeSH terms
Bone Marrow, Humans, Whole-Body Irradiation, Cytokines, Radioactive Hazard Release

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Hematopoietic Recovery using Multi-Cytokine Therapy in 8 Patients Presenting Radiation-Induced Myelosuppression after Radiological Accidents. https://app.cochat.ai/papers/10.1667/rade-21-00169.1
The paper
Benderitter, M., Herrera-Reyes, E., Gigov, Y., Souleau, B., Huet, C., Trompier, F., Fagot, T., Grégoire, E., Malfuson, J. V., Konopacki-Potet, J., Buglova, E., Lataillade, J.-J., Tamarat, R., Gourmelon, P., & de Revel, T. (2021). Hematopoietic Recovery using Multi-Cytokine Therapy in 8 Patients Presenting Radiation-Induced Myelosuppression after Radiological Accidents. Radiation Research. https://doi.org/10.1667/rade-21-00169.1

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.