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Cited by 15Effects of Radiation ExposureHematopoietic Stem Cell TransplantationNeutropenia and Cancer Infections

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Hematopoietic Recovery using Multi-Cytokine Therapy in 8 Patients Presenting Radiation-Induced Myelosuppression after Radiological Accidents

Benderitter, Marc, Herrera-Reyes, Eduardo, Gigov, Yvan, Souleau, Bertrand, Huet, Christelle, Trompier, François, Fagot, Thierry, Grégoire, Eric, Malfuson, Jean Valère, Konopacki-Potet, Johanna, Buglova, Elena, Lataillade, Jean-Jacques, Tamarat, Radia, Gourmelon, Patrick, de Revel, Thierry·2021·Radiation Research
DOI 10.1667/rade-21-00169.1
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Abstract

Treatment of accidental radiation-induced myelosuppression is primarily based on supportive care and requires specific treatment based on hematopoietic growth factors injection or hematopoietic cell transplantation for the most severe cases. The cytokines used consisted of pegylated erythropoietin (darbepoetin alfa) 500 IU once per week, pegylated G-CSF (pegfilgrastim) 6 mg × 2 once, stem cell factor 20 µg.kg-1 for five days, and romiplostim (TPO analog) 10 µg.kg -1 once per week, with different combinations depending on the accidents. As the stem cell factor did not have regulatory approval for clinical use in France, the French regulatory authorities (ANSM, formerly, AFSSAPS) approved their compassionate use as an investigational drug "on a case-by-case basis". According to the evolution and clinical characteristics, each patient's treatment was adopted on an individual basis. Daily blood count allows initiating G-CSF and SCF delivery when granulocyte <1,000/mm3, TPO delivery when platelets <50,000/mm3, and EPO when Hb<80 g/L. The length of each treatment was based on blood cell recovery criteria. The concept of "stimulation strategy" is linked to each patient's residual hematopoiesis, which varies among them, depending on the radiation exposure's characteristics and heterogeneity. This paper reports the medical management of 8 overexposed patients to ionizing radiation. The recovery of bone marrow function after myelosuppression was accelerated using growth factors, optimi…

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Crossref · 10.1667/rade-21-00169.1

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57 of 57 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. AM El-Naggar, MH Mohammad, MA Gomaa, "The Medical Basis for Nuclear Accident Preparedness. The Clinical Care of Victims. Proceedings of the Fourth International REAC/TS Conference on the Medical Basis for Radiation-Accident Preparedness (held March 6-8, 2001, in Orlando, Florida)." "The radiological accident at Meet Halfa, Qaluobiya, Egypt." 316 (2002)
  2. V. Jinaratana, "The medical basis for radiation-accidents preparedness. The Clinical care of victims proceeding of the fourth international REAC/TS conference on the medical basis for radiation accidents preparedness (held March 6-8, 2001, in Orlando, Florida)." "The radiological accident in Thailand." 283 (2002)
  3. T MacVittie and A Faresse "The medical basis for radiation-accidents preparedness the clinical care of victims proceeding of the fourth international REAC/TS conference on the medical basis for radiation accidents preparedness (held March 6-8, 2001, in Orlando, Florida)." "Cytokine-based treatment for acute radiation-induced myelosuppression: preclinical and clinical perspective." 53 (2002)

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Metadata

Authors
Benderitter, M., Herrera-Reyes, E., Gigov, Y., Souleau, B., Huet, C., Trompier, F., Fagot, T., Grégoire, E., Malfuson, J. V., Konopacki-Potet, J., Buglova, E., Lataillade, J.-J., Tamarat, R., Gourmelon, P., & de Revel, T.
Affiliations
  • Institut de Radioprotection et de Sûreté Nucléaire (FR)
  • Military Hospital, Department of Hematology and Chemotherapy for Solid Tumors, Sofia, Bulgaria
  • Hôpital d'instruction des Armées Percy (FR)
  • International Atomic Energy Agency (AT)
  • Ecole du Val de Grâce, 75005 Paris, France
Corresponding author
Benderitter, Marc
ORCID
Venue
Radiation Research
Publisher
Radiation Research Society
Published
2021-09-23
Volume
196
Issue
6
Pages
668-679
ISSN
  • 0033-7587 (ISSN-L)
  • 1938-5404
DOI
10.1667/rade-21-00169.1
OpenAlex
W3201501110
Cited by
15
References
57
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4
FWCI
1.33
Type
journal article
Language
en
Open access
closed
Locations
  • Radiation Research (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Keywords
radiation-induced myelosuppression, hematopoietic recovery, pegfilgrastim, darbepoetin alfa, romiplostim, stem cell factor, radiation accidents, hematopoietic growth factors, compassionate use, bone marrow function
MeSH terms
Bone Marrow, Humans, Whole-Body Irradiation, Cytokines, Radioactive Hazard Release

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