The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Copper deficiency as an anti-cancer strategy.
Open accessAbstract
Copper is a tightly regulated trace element. Disruptions of copper homeostasis are rare and they cause serious disorders such as Wilson's disease and Menkes disease. Copper also plays an important role in promoting physiological and malignant angiogenesis. Formation of new blood vessels by a tumor enables tumor growth, invasion and metastasis. The copper chelator tetrathiomolybdate (TM), which quickly and effectively depletes copper stores, is under investigation as an anti-angiogenic agent. Promising results in vitro, in pre-clinical animal models and in an early (phase I) clinical trial have led to ongoing phase II evaluation of TM in patients with advanced cancers.
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Cites
Copper-induced vascular endothelial growth factor expression and wound healing
Sen, C. K., Khanna, S., Venojarvi, M., Trikha, P., Ellison, E. C., Hunt, T. K., & Roy, S. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01015.2001 · Cited by 522
Intestinal metallothionein and the mutual antagonism between copper and zinc in the rat
Hall, A. C., Young, B. W., & Bremner, I. (1979) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)80054-9 · Cited by 200
Cited by
Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355
Itoh, S., Kim, H. W., Nakagawa, O., Ozumi, K., Lessner, S. M., Aoki, H., Akram, K., McKinney, R. D., Ushio-Fukai, M., & Fukai, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709463200 · Cited by 317
Human Copper Transporters: Mechanism, Role in Human Diseases and Therapeutic Potential
Gupta, A., & Lutsenko, S. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.84 · Cited by 275
Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo
Das, A., Sudhahar, V., Chen, G.-F., Kim, H. W., Youn, S.-W., Finney, L., Vogt, S., Yang, J., Kweon, J., Surenkhuu, B., et al. (2016) · Scientific Reports · doi:10.1038/srep33783 · Cited by 89
Metadata
- Authors
- Goodman, V. L., Brewer, G. J., & Merajver, S. D.
- Venue
- Endocrine-related cancer
- Publisher
- Bioscientifica
- Published
- 2004-06
- Volume
- 11
- Issue
- 2
- Pages
- 255-263
- ISSN
- 1351-0088 (ISSN-L)
- OpenAlex
- W2144825640
- Cited by
- 168
- References
- 2
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
