The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Human Copper Transporters: Mechanism, Role in Human Diseases and Therapeutic Potential
Open accessAbstract
Normal copper homeostasis is essential for human growth and development. Copper deficiency, caused by genetic mutations, inadequate diet or surgical interventions, may lead to cardiac hypertrophy, poor neuronal myelination, blood vessel abnormalities and impaired immune response. Copper overload is associated with morphological and metabolic changes in tissues and, if untreated, eventual death. Recent reports also indicate that changes in the expression of copper transporters alter the sensitivity of cancer cells to major chemotherapeutic drugs, such as cisplatin, although the mechanism behind this important phenomenon remains unclear. This review summarizes current information on the molecular characteristics of copper transporters CTR1, CTR2, ATP7A and ATP7B, their roles in mammalian copper homeostasis and the physiological consequences of their inactivation. The mechanisms through which copper transporters may influence cell sensitivity to cisplatin are discussed. Regulation of human copper homeostasis has significant therapeutic potential and requires the detailed understanding of copper transport mechanisms.
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Cites
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Biology, structure and mechanism of P-type ATPases
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Cited by
Copper bioavailability, uptake, toxicity and tolerance in plants: A comprehensive review
Kumar, V., Pandita, S., Singh Sidhu, G. P., Sharma, A., Khanna, K., Kaur, P., Bali, A. S., & Setia, R. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2020.127810 · Cited by 594
Copper Homeostasis at the Host-Pathogen Interface
Hodgkinson, V., & Petris, M. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.316406 · Cited by 316
Cu Homeostasis in Bacteria: The Ins and Outs
Andrei, A., Öztürk, Y., Khalfaoui-Hassani, B., Rauch, J., Marckmann, D., Trasnea, P.-I., Daldal, F., & Koch, H.-G. (2020) · Membranes · doi:10.3390/membranes10090242 · Cited by 153
Ugwu, E. I., Othmani, A., & Nnaji, C. C. (2022) · International Journal of Environmental Science and Technology · doi:10.1007/s13762-021-03560-3 · Cited by 105
The Mechanism of Cu+ Transport ATPases
Padilla-Benavides, T., McCann, C. J., & Argüello, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.420810 · Cited by 81
Metadata
- Authors
- Gupta, A., & Lutsenko, S.
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2009-09
- Volume
- 1
- Issue
- 6
- Pages
- 1125-1142
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- OpenAlex
- W1967868572
- Cited by
- 275
- References
- 96
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
