The DOI matches its Crossref record.
Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockouts
Abstract
Analysis of mice with naturally occurring mutations in the genes encoding the tyrosine kinase receptor protein, c-kit, and its ligand, stem cell factor (SCF), has implicated these proteins in testicular development and function because of the phenotype of these mice of reduced or absent fertility. Descriptive and functional studies have highlighted the involvement of these proteins in primordial germ cell migration and survival, and in spermatogonial proliferation, survival and adhesion. This review summarises the current knowledge regarding functions of c-kit and SCF in the testis and discusses the implications of information gleaned from other biological systems. Journal of Endocrinology (1997) 153, 337–344
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Citations
Cited by
Hermo, L., Pelletier, R. ‐., Cyr, D. G., & Smith, C. E. (2010) · Microscopy Research and Technique · doi:10.1002/jemt.20783 · Cited by 422
Activating c-kit Gene Mutations in Human Germ Cell Tumors
Tian, Q., Frierson, H. F., Krystal, G. W., & Moskaluk, C. A. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65419-3 · Cited by 408
Mouse models of male infertility
Cooke, H. J., & Saunders, P. T. K. (2002) · Nature Reviews Genetics · doi:10.1038/nrg911 · Cited by 301
Two mouse piwi-related genes: miwi and mili
Kuramochi-Miyagawa, S., Kimura, T., Yomogida, K., Kuroiwa, A., Tadokoro, Y., Fujita, Y., Sato, M., Matsuda, Y., & Nakano, T. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00499-3 · Cited by 269
Wang, X., Ding, Q., Zhang, Y., Wang, H., Ma, L., & Xie, X. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.08.049 · Cited by 10
Metadata
- Authors
- Loveland, K. L., & Schlatt, S.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1997-06
- Volume
- 153
- Issue
- 3
- Pages
- 337-344
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2057156376
- Cited by
- 173
- References
- 0
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Loveland, K. L., & Schlatt, S. (1997). Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockouts. Journal of Endocrinology. https://doi.org/10.1677/joe.0.1530337
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