Rapid regulation of thyroid sodium–iodide symporter activity by thyrotrophin and iodine
Open accessAbstract
Transport of iodide into thyrocytes, a fundamental step in thyroid hormone biosynthesis, depends on the presence of the sodium–iodide symporter (NIS). The importance of the NIS for diagnosis and treatment of diseases has raised several questions about its physiological control. The goal of this study was to evaluate the influence of thyroid iodine content on NIS regulation by thyrotrophin (TSH) in vivo . We showed that 15-min thyroid radioiodine uptake can be a reliable measurement of NIS activity in vivo . The effect of TSH on the NIS was evaluated in rats treated with 1-methyl-2-mercaptoimidazole (MMI; hypothyroid with high serum TSH concentrations) for 21 days, and after 1 (R1d), 2 (R2d), or 5 (R5d) days of withdrawal of MMI. NIS activity was significantly greater in both MMI and R1d rats. In R2d and R5d groups, thyroid iodide uptake returned to normal values, despite continuing high serum TSH, possibly as a result of the re-establishment of iodine organification after withdrawal of MMI. Excess iodine (0.05% NaI for 6 days) promoted a significant reduction in thyroid radioiodide uptake, an effect that was blocked by concomitant administration of MMI, confirming previous findings that iodine organification is essential for the iodide transport blockade seen during iodine overload. Therefore, our data show that modulation of the thyroid NIS by TSH depends primarily on thyroid iodine content and, further, that the regulation of NIS activity is rapid.
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Measurement of radioiodide uptake 15 min after 125I-NaI administration reflects iodide transport through the sodium-iodide symporter (NIS) without the influence of in vivo thyroid iodine organification activity.
“We had previously demonstrated that the measurement of radioiodide uptake 15 min after 125I-NaI administration (short-term iodide uptake) reflects iodide transport through the sodium–iodide symporter (NIS) without the influence of in vivo thyroid iodine organification activity (Ferreira et al. 2005).”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Ferreira et al. 2005
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Research works printed but not linked: 15
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Olivares, E. L., Marassi, M. P., Fortunato, R. S., da Silva, A. C. M., Costa-e-Sousa, R. H., Araújo, I. G., Mattos, E. C., Masuda, M. O., Mulcahey, M. A., Huang, S. A., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0043 · Cited by 145 · see citing works
Self-citationPadron, A. S., Neto, R. A. L., Pantaleão, T. U., de Souza dos Santos, M. C., Araujo, R. L., de Andrade, B. M., da Silva Leandro, M., de Castro, J. P. S. W., Ferreira, A. C. F., & de Carvalho, D. P. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0502 · Cited by 69 · see citing works
Self-citationIntrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion
Jing, L., & Zhang, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.992883 · Cited by 61 · see citing works
- Authors
- Ferreira, A. C. F., Lima, L. P., Araújo, R. L., Müller, G., Rocha, R. P., Rosenthal, D., & Carvalho, D. P.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2005-01
- Volume
- 184
- Issue
- 1
- Pages
- 69-76
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2145813743
- Cited by
- 86
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 8 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Keywords
- sodium iodide symporter, thyroid-stimulating hormone, thyroid iodide uptake, iodine organification, iodide transport, 1-methyl-2-mercaptoimidazole, hypothyroidism, iodine excess, thyroid hormone synthesis, radioiodine uptake
- MeSH terms
- Sodium-Iodide Symporters, Animals, Hypothyroidism, Iodine, Male, Methimazole, Thyroid Gland, Thyrotropin, Time Factors, Rats, Wistar, Symporters, Rats
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