Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study
Abstract
In humans, there is a significant decrease in serum T(3) and increase in rT(3) at different time points after myocardial infarction, whereas serum TSH and T(4) remain unaltered. We report here a time course study of pituitary-thyroid function and thyroid hormone metabolism in rats subjected to myocardial infarction by left coronary ligation (INF). INF- and sham-operated animals were followed by serial deiodination assays and thyroid function tests, just before, and 1, 4, 8, and 12 wk after surgery. At 4 and 12 wk after INF, liver type 1 deiodinase activity was significantly lower, confirming tissue hypothyroidism. Type 3 deiodinase (D3) activity was robustly induced 1 wk after INF only in the infarcted myocardium. Reminiscent of the consumptive hypothyroidism observed in patients with large D3-expressing tumors, this induction of cardiac D3 activity was associated with a decrease in both serum T(4) ( approximately 50% decrease) and T(3) (37% decrease), despite compensatory stimulation of the thyroid. Thyroid stimulation was documented by both hyperthyrotropinemia and radioiodine uptake. Serum TSH increased by 4.3-fold in the first and 3.1-fold in the fourth weeks (P < 0.01), returning to the basal levels thereafter. Thyroid sodium/iodide-symporter function increased 1 wk after INF, accompanying the increased serum TSH. We conclude that the acute decrease in serum T(4) and T(3) after INF is due to increased thyroid hormone catabolism from ectopic D3 expression in the heart.
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T3 down-regulation is consistent with experimental data showing that changes in circulating thyroid hormone parameters after acute myocardial infarction result from increased D3 activity and reduced D1 and D2 activity.
“T 3 down-regulation is consistent with experimental data showing that changes in circulating TH parameters after AMI are a result of increased D3 activity and reduced D1 and D2 activity (115).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [115]
In rats, the acute decrease in serum T4 and T3 after acute myocardial infarction is mediated by induction of D3 activity in the heart.
“studies in rats have shown that the acute decrease in serum T 4 and T 3 after AMI is mediated by the induction of D3 activity in the heart (115).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [115]
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- Authors
- Olivares, E. L., Marassi, M. P., Fortunato, R. S., da Silva, A. C. M., Costa-e-Sousa, R. H., Araújo, I. G., Mattos, E. C., Masuda, M. O., Mulcahey, M. A., Huang, S. A., Bianco, A. C., & Carvalho, D. P.
- Affiliations
- Universidade Federal Rural do Rio de Janeiro (BR)
- Universidade Federal do Rio de Janeiro (BR)
- Laboratórios de Fisiologia Endócrina (M.P.M., R.S.F., A.C.M.S., D.P.C.), Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Bloco G, Ilha do Fundão, CEP 21949-900 Rio de Janeiro, Brazil
- Departamento de Ciências Fisiológicas (E.L.O., R.H.C.S., I.G.A.), Instituto de Biologia, Universidade Federal Rural do Rio de Janeiro, CEP 23890-000, Seropédica, Rio de Janeiro, Brazil
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-10-01
- Volume
- 148
- Issue
- 10
- Pages
- 4786-4792
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2136006969
- Cited by
- 145
- References
- 40
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 17 · 2019: 5 · 2018: 10 · 2017: 7 · 2016: 12 · 2015: 12 · 2014: 7 · 2013: 6 · 2012: 5
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- myocardial infarction, type 3 iodothyronine deiodinase, thyroid hormone metabolism, thyroid function, thyroid-stimulating hormone, sodium iodide symporter, triiodothyronine, thyroxine
- MeSH terms
- Sodium-Iodide Symporters, Animals, Heart, Iodide Peroxidase, Iodine Radioisotopes, Male, Myocardial Infarction, Myocardium, Radioimmunoassay, Thyroid Gland, Thyrotropin, Thyrotropin-Releasing Hormone, Thyroxine, Time Factors, Triiodothyronine, Rats, Wistar, Symporters, Rats
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