The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
11β-Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action
Open accessAbstract
Two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD1 and 11β-HSD2) catalyse the interconversion of hormonally active cortisol and inactive cortisone. The enzyme evolved from a metabolic pathway to a novel mechanism underpinning human disease with the elucidation of the role of the type 2 or ‘kidney’ isozyme and an inherited form of hypertension, ‘apparent mineralocorti-coid excess’. ‘Cushing’s disease of the kidney’ arises because of a failure of 11β-HSD2 to inactivate cortisol to cortisone resulting in cortisol-induced mineralocorticoid excess. Conversely, 11β-HSD1 has been linked to human obesity and insulin resistance, but also to other diseases in which glucocorticoids have historically been implicated (osteoporosis, glaucoma). Here, the activation of cortisol from cortisone facilitates glucocorticoid hormone action at an autocrine level. The molecular basis for the putative human 11β-HSD1 ‘knockout’ – ‘cortisone reductase deficiency’ - has recently been described, an observation that also answers a long standing conundrum relating to the set-point of 11β-HSD1 activity. In each case, these clinical studies have been underpinned by studies in vitro and the manipulation of enzyme expression in vivo using recombinant mouse models.
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Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461
Metabolomics for clinical use and research in chronic kidney disease
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Metadata
- Authors
- Draper, N., & Stewart, P. M.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2005-08
- Volume
- 186
- Issue
- 2
- Pages
- 251-271
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2117456369
- Cited by
- 375
- References
- 179
- FWCI
- 14.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
