Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited
Abstract
Transcription and translation require a high concentration of potassium across the entire tree of life. The conservation of a high intracellular potassium was an absolute requirement for the evolution of life on Earth. This was achieved by the interplay of P- and V-ATPases that can set up electrochemical gradients across the cell membrane, an energetically costly process requiring the synthesis of ATP by F-ATPases. In animals, the control of an extracellular compartment was achieved by the emergence of multicellular organisms able to produce tight epithelial barriers creating a stable extracellular milieu. Finally, the adaptation to a terrestrian environment was achieved by the evolution of distinct regulatory pathways allowing salt and water conservation. In this review we emphasize the critical and dual role of Na(+)-K(+)-ATPase in the control of the ionic composition of the extracellular fluid and the renin-angiotensin-aldosterone system (RAAS) in salt and water conservation in vertebrates. The action of aldosterone on transepithelial sodium transport by activation of the epithelial sodium channel (ENaC) at the apical membrane and that of Na(+)-K(+)-ATPase at the basolateral membrane may have evolved in lungfish before the emergence of tetrapods. Finally, we discuss the implication of RAAS in the origin of the present pandemia of hypertension and its associated cardiovascular diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aldosterone promotes sodium and water retention, as well as potassium excretion by the kidney.
“Aldosterone, a mineralocorticoid, in turn promotes sodium and water retention, as well as potassium excretion by the kidney (7).”
From Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies (2016) · cites this paper as [7]
Cites
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584 · see citing works
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336 · see citing works
A Production of Amino Acids Under Possible Primitive Earth Conditions
Miller, S. L. (1953) · Science · doi:10.1126/science.117.3046.528 · Cited by 3,522 · see citing works
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
Heery, D. M., Kalkhoven, E., Hoare, S., & Parker, M. G. (1997) · Nature · doi:10.1038/42750 · Cited by 2,128 · see citing works
Molecular Mechanisms of Human Hypertension
Lifton, R. P., Gharavi, A. G., & Geller, D. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00241-0 · Cited by 1,686 · see citing works
Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
Yi, X., Liang, Y., Huerta-Sanchez, E., Jin, X., Cuo, Z. X. P., Pool, J. E., Xu, X., Jiang, H., Vinckenbosch, N., Korneliussen, T. S., et al. (2010) · Science · doi:10.1126/science.1190371 · Cited by 1,611 · cited 1× · see citing works
“Another case is that of a gene, EPAS1 or HIF2 (coding for a transcription factor involved in hemoglobin concentration), conferring resistance to hypoxia to populations living at high elevation (Tibetan, Andean) (22, 350).”
BackgroundDating the rise of atmospheric oxygen
Bekker, A., Holland, H. D., Wang, P.-L., Rumble, D., Stein, H. J., Hannah, J. L., Coetzee, L. L., & Beukes, N. J. (2004) · Nature · doi:10.1038/nature02260 · Cited by 1,435 · see citing works
A molecular phylogeny of living primates
Perelman, P., Johnson, W. E., Roos, C., Seuánez, H. N., Horvath, J. E., Moreira, M. A. M., Kessing, B., Pontius, J., Roelke, M., Rumpler, Y., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001342 · Cited by 1,414 · cited 1× · see citing works
“(255), based on a wealth of new genomic data, comparative genomic analyses of primates allow resolving the primate phylogeny with a much greater accuracy.”
BackgroundElliott, P., Stamler, J., Nichols, R., Dyer, A. R., Stamler, R., Kesteloot, H., & Marmot, M. (1996) · BMJ · doi:10.1136/bmj.312.7041.1249 · Cited by 855 · see citing works
A Revised Timescale for Human Evolution Based on Ancient Mitochondrial Genomes
Fu, Q., Mittnik, A., Johnson, P. L. F., Bos, K., Lari, M., Bollongino, R., Sun, C., Giemsch, L., Schmitz, R., Burger, J., et al. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.044 · Cited by 709 · see citing works
The Genome of the Ctenophore <i>Mnemiopsis leidyi</i> and Its Implications for Cell Type Evolution
Ryan, J. F., Pang, K., Schnitzler, C. E., Nguyen, A.-D., Moreland, R. T., Simmons, D. K., Koch, B. J., Francis, W. R., Havlak, P., Program, N. C. S., et al. (2013) · Science · doi:10.1126/science.1242592 · Cited by 702 · see citing works
The Date of Interbreeding between Neandertals and Modern Humans
Sankararaman, S., Patterson, N., Li, H., Pääbo, S., & Reich, D. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002947 · Cited by 460 · see citing works
The origin of membrane bioenergetics
Lane, N., & Martin, W. F. (2012) · Cell · doi:10.1016/j.cell.2012.11.050 · Cited by 452 · see citing works
Speakman, J. R. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.161 · Cited by 361 · see citing works
Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance
Rakova, N., Jüttner, K., Dahlmann, A., Schröder, A., Linz, P., Kopp, C., Rauh, M., Goller, U., Beck, L., Agureev, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.013 · Cited by 328 · see citing works
Sousa, F. L., Thiergart, T., Landan, G., Nelson-Sathi, S., Pereira, I. A. C., Allen, J. F., Lane, N., & Martin, W. F. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0088 · Cited by 286 · cited 1× · see citing works
“Thus the understanding of membrane bioenergetics is crucial to understand how energy (ATP) is generated and how it is provided to the different machineries inside the cell (65, 190, 303, 306).”
BackgroundCo-evolution of primordial membranes and membrane proteins
Mulkidjanian, A. Y., Galperin, M. Y., & Koonin, E. V. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.01.005 · Cited by 169 · see citing works
Bioenergetics and Life’s Origins
Deamer, D., & Weber, A. L. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004929 · Cited by 165 · see citing works
Emergence and evolution of the renin-angiotensin-aldosterone system
Fournier, D., Luft, F. C., Bader, M., Ganten, D., & Andrade-Navarro, M. A. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0894-z · Cited by 165 · see citing works
Evolutionary primacy of sodium bioenergetics
Mulkidjanian, A. Y., Galperin, M. Y., Makarova, K. S., Wolf, Y. I., & Koonin, E. V. (2008) · Biology Direct · doi:10.1186/1745-6150-3-13 · Cited by 163 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Clase, C. M., Carrero, J.-J., Ellison, D. H., Grams, M. E., Hemmelgarn, B. R., Jardine, M. J., Kovesdy, C. P., Kline, G. A., Lindner, G., Obrador, G. T., et al. (2020) · Kidney International · doi:10.1016/j.kint.2019.09.018 · Cited by 498 · see citing works
Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits
McDonough, A. A., & Youn, J. H. (2017) · Physiology · doi:10.1152/physiol.00022.2016 · Cited by 146 · see citing works
Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies
Midzak, A., & Papadopoulos, V. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00106 · Cited by 114 · see citing works
“Aldosterone, a mineralocorticoid, in turn promotes sodium and water retention, as well as potassium excretion by the kidney (7).”
Background
- Authors
- Rossier, B. C., Baker, M. E., & Studer, R. A.
- Affiliations
- University of California San Diego (US)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2015-01
- Volume
- 95
- Issue
- 1
- Pages
- 297-340
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2037612479
- Cited by
- 269
- References
- 20
- Citations by year
- 2026: 19 · 2025: 9 · 2024: 24 · 2023: 32 · 2022: 19 · 2021: 30 · 2020: 20 · 2019: 26 · 2018: 23 · 2017: 27 · 2016: 30 · 2015: 10
- Type
- conference abstract
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion, public-domain)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- epithelial sodium transport, aldosterone, Na+/K+-ATPase, epithelial sodium channel, renin-angiotensin-aldosterone system, evolution of multicellularity, lungfish, hypertension, cardiovascular disease, potassium homeostasis
- MeSH terms
- Sodium-Potassium-Exchanging ATPase, Aldosterone, Animals, Biological Evolution, Humans, Nephrons, Sodium, Signal Transduction, Genome, Human, Epithelial Sodium Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
