The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Oxidative and nitrosative stress in brain mitochondria of diabetic rats
Open accessAbstract
Diabetic encephalopathy, characterized by impaired cognitive functions and neurochemical and structural abnormalities, may involve direct neuronal damage caused by intracellular glucose. The study assesses the direct effect of chronic hyperglycemia on the function of brain mitochondria, the major site of reactive species production, in diabetic streptozotocin (STZ) rats. Oxidative stress plays a central role in diabetic tissue damage. Alongside enhanced reactive oxygen species (ROS) levels, both nitric oxide (NO) levels and mitochondrial nitric oxide synthase expression were found to be increased in mitochondria, whereas glutathione (GSH) peroxidase activity and manganese superoxide dismutase protein content were reduced. GSH was reduced and GSH disulfide (GSSG) was increased in STZ rats. Oxidative and nitrosative stress, by reducing the activity of complexes III, IV and V of the respiratory chain and decreasing ATP levels, might contribute to mitochondrial dysfunction. In summary, this study offers fresh evidence that, besides the vascular-dependent mechanisms of brain dysfunction, oxidative and nitrosative stress, by damaging brain mitochondria, may cause direct injury of neuronal cells.
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Cites
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258
Nitric oxide and mitochondrial respiration
Brown, G. C. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00025-0 · Cited by 702
Selective targeting of an antioxidant to mitochondria
Smith, R. A. J., Porteous, C. M., Coulter, C. V., & Murphy, M. P. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00543.x · Cited by 466
Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase
Raha, S., McEachern, G. E., Myint, A. T., & Robinson, B. H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00338-5 · Cited by 223
Effect of Streptozotocin‐Induced Diabetes on Rat Brain Mitochondria
Moreira, P. I., Santos, M. S., Moreno, A. M., Proença, T., Seiça, R., & Oliveira, C. R. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.1107.x · Cited by 47
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Glutathione dysregulation and the etiology and progression of human diseases
Ballatori, N., Krance, S. M., Notenboom, S., Shi, S., Tieu, K., & Hammond, C. L. (2009) · bchm · doi:10.1515/bc.2009.033 · Cited by 1,114
The central role of glutathione in the pathophysiology of human diseases
Franco, R., Schoneveld, O. J., Pappa, A., & Panayiotidis, M. I. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450701661198 · Cited by 536
Luteolin as an anti-inflammatory and neuroprotective agent: A brief review
Nabavi, S. F., Braidy, N., Gortzi, O., Sobarzo-Sanchez, E., Daglia, M., Skalicka-Woźniak, K., & Nabavi, S. M. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.09.002 · Cited by 480
Diabetic peripheral neuropathy: Current perspective and future directions
Singh, R., Kishore, L., & Kaur, N. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2013.12.005 · Cited by 400
Mitochondrial glutathione transport: Physiological, pathological and toxicological implications
Lash, L. H. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.03.001 · Cited by 279
Metadata
- Authors
- Mastrocola, R., Restivo, F., Vercellinatto, I., Danni, O., Brignardello, E., Aragno, M., & Boccuzzi, G.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2005-10
- Volume
- 187
- Issue
- 1
- Pages
- 37-44
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2153770540
- Cited by
- 268
- References
- 7
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mastrocola, R., Restivo, F., Vercellinatto, I., Danni, O., Brignardello, E., Aragno, M., & Boccuzzi, G. (2005). Oxidative and nitrosative stress in brain mitochondria of diabetic rats. Journal of Endocrinology. https://doi.org/10.1677/joe.1.06269
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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