The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Isolation and Characterization of Kidney-Derived Stem Cells
Abstract
Acute kidney injury is followed by regeneration of damaged renal tubular epithelial cells. The purpose of this study was to test the hypothesis that renal stem cells exist in the adult kidney and participate in the repair process. A unique population of cells that behave in a manner that is consistent with a renal stem cell were isolated from rat kidneys and were termed multipotent renal progenitor cells (MRPC). Features of these cells include spindle-shaped morphology; self-renewal for >200 population doublings without evidence for senescence; normal karyotype and DNA analysis; and expression of vimentin, CD90 (thy1.1), Pax-2, and Oct4 but not cytokeratin, MHC class I or II, or other markers of more differentiated cells. MRPC exhibit plasticity that is demonstrated by the ability of the cells to be induced to express endothelial, hepatocyte, and neural markers by reverse transcriptase-PCR and immunohistochemistry. The cells can differentiate into renal tubules when injected under the capsule of an uninjured kidney or intra-arterially after renal ischemia-reperfusion injury. Oct4 expression was seen in some tubular cells in the adult kidney, suggesting these cells may be candidate renal stem cells. It is proposed that MRPC participate in the regenerative response of the kidney to acute injury.
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1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,518
Self-citationRetractedTögel, F., Hu, Z., Weiss, K., Isaac, J., Lange, C., & Westenfelder, C. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00007.2005 · Cited by 1,178
Pax-2 controls multiple steps of urogenital development
Torres, M., Gómez-Pardo, E., Dressler, G. R., & Gruss, P. (1995) · Development · doi:10.1242/dev.121.12.4057 · Cited by 897
Morrison, S. J., White, P. M., Zock, C., & Anderson, D. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80583-8 · Cited by 750
Isolation of Renal Progenitor Cells from Adult Human Kidney
Bussolati, B., Bruno, S., Grange, C., Buttiglieri, S., Deregibus, M. C., Cantino, D., & Camussi, G. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62276-6 · Cited by 644
Bone marrow contributes to renal parenchymal turnover and regeneration
Poulsom, R., Forbes, S. J., Hodivala-Dilke, K., Ryan, E., Wyles, S., Navaratnarasah, S., Jeffery, R., Hunt, T., Alison, M., Cook, T., et al. (2001) · The Journal of Pathology · doi:10.1002/path.976 · Cited by 644
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The renal papilla is a niche for adult kidney stem cells
Oliver, J. A., Maarouf, O., Cheema, F. H., Martens, T. P., & Al-Awqati, Q. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420921 · Cited by 534
Cited by
Intrinsic Epithelial Cells Repair the Kidney after Injury
Humphreys, B. D., Valerius, M. T., Kobayashi, A., Mugford, J. W., Soeung, S., Duffield, J. S., McMahon, A. P., & Bonventre, J. V. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.01.014 · Cited by 868
Mechanisms of Tubulointerstitial Fibrosis
Zeisberg, M., & Neilson, E. G. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080793 · Cited by 868
Differentiated kidney epithelial cells repair injured proximal tubule
Kusaba, T., Lalli, M., Kramann, R., Kobayashi, A., & Humphreys, B. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310653110 · Cited by 476
Oct4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal
Lengner, C. J., Camargo, F. D., Hochedlinger, K., Welstead, G. G., Zaidi, S., Gokhale, S., Scholer, H. R., Tomilin, A., & Jaenisch, R. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.07.020 · Cited by 411
Concise Review: Kidney Stem/Progenitor Cells: Differentiate, Sort Out, or Reprogram?
Pleniceanu, O., Harari-Steinberg, O., & Dekel, B. (2010) · Stem Cells · doi:10.1002/stem.486 · Cited by 100
Metadata
- Authors
- Gupta, S., Verfaillie, C., Chmielewski, D., Kren, S., Eidman, K., Connaire, J., Heremans, Y., Lund, T., Blackstad, M., Jiang, Y., Luttun, A., & Rosenberg, M. E.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2006-11
- Volume
- 17
- Issue
- 11
- Pages
- 3028-3040
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2105647704
- Cited by
- 286
- References
- 32
- FWCI
- 15.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gupta, S., Verfaillie, C., Chmielewski, D., Kren, S., Eidman, K., Connaire, J., Heremans, Y., Lund, T., Blackstad, M., Jiang, Y., Luttun, A., & Rosenberg, M. E. (2006). Isolation and Characterization of Kidney-Derived Stem Cells. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2006030275
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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