Concise Review: Kidney Stem/Progenitor Cells: Differentiate, Sort Out, or Reprogram?
Open accessAbstract
End-stage renal disease (ESRD) is defined as the inability of the kidneys to remove waste products and excess fluid from the blood. ESRD progresses from earlier stages of chronic kidney disease (CKD) and occurs when the glomerular filtration rate (GFR) is below 15 ml/minute/1.73 m2. CKD and ESRD are dramatically rising due to increasing aging population, population demographics, and the growing rate of diabetes and hypertension. Identification of multipotential stem/progenitor populations in mammalian tissues is important for therapeutic applications and for understanding developmental processes and tissue homeostasis. Progenitor populations are ideal targets for gene therapy, cell transplantation, and tissue engineering. The demand for kidney progenitors is increasing due to severe shortage of donor organs. Because dialysis and transplantation are currently the only successful therapies for ESRD, cell therapy offers an alternative approach for kidney diseases. However, this approach may be relevant only in earlier stages of CKD, when kidney function and histology are still preserved, allowing for the integration of cells and/or for their paracrine effects, but not when small and fibrotic end-stage kidneys develop. Although blood- and bone marrow-derived stem cells hold a therapeutic promise, they are devoid of nephrogenic potential, emphasizing the need to seek kidney stem cells beyond known extrarenal sources. Moreover, controversies regarding the existence of a true adult kidney stem cell highlight the importance of studying cell-based therapies using pluripotent cells, progenitor cells from fetal kidney, or dedifferentiated/reprogrammed adult kidney cells.
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Epithelial-mesenchymal interactions trigger the development of various tissues and organs through specific signaling pathways and transcription factors.
“During the early developmental stages, epithelial-mesenchymal interactions (EMIs) trigger the development of various tissues and organs through specific signaling pathways and transcription factors.”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [2]
The Developmental Nephrology section and Figure 1 describe reciprocal mesenchymal–ureteric bud interactions in kidney development, including WNT signals and transcription factors. They support the kidney example, but our copy does not establish the broader claim that such interactions trigger development of various tissues and organs. (LLM, conf=0.84)
Experimental — accuracy not yet measuredEMIs drive stomach specification, kidney duct patterning, lung development, lacrimal gland bud formation, and teeth bud formation.
“For example, EMIs drive stomach specification (1), duct patterning of the kidney (2) and lung (3), and bud formation of the lacrimal gland (4) and teeth (5).”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [2]
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- Authors
- Pleniceanu, O., Harari-Steinberg, O., & Dekel, B.
- Affiliations
- Tel Aviv University (IL)
- Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Israel
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07-22
- Volume
- 28
- Issue
- 9
- Pages
- 1649-1660
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- PMC
- PMC2996087
- OpenAlex
- W2091203020
- Cited by
- 100
- References
- 131
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 11 · 2016: 7 · 2015: 5 · 2014: 11 · 2013: 8 · 2012: 10
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Stem Cells (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Israel Cancer Research Fund
- Israel Science Foundation
- Tel Aviv University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Renal and related cancers
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- kidney stem cells, kidney progenitor cells, end-stage renal disease, chronic kidney disease, cell therapy, pluripotent cells, dedifferentiation, cellular reprogramming, paracrine effects, renal fibrosis, cell transplantation, tissue engineering
- MeSH terms
- Animals, Cell Differentiation, Cell Separation, Glomerular Filtration Rate, Humans, Kidney, Kidney Failure, Chronic, Genetic Therapy, Gene Expression Regulation, Developmental, Stem Cell Transplantation, Pluripotent Stem Cells, Fetal Stem Cells, Adult Stem Cells
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