The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Physiology and Pathophysiology of Heme: Implications for Kidney Disease
Abstract
An iron-containing, tetrapyrrole ring, heme is an essential prosthetic group in an array of proteins that comprehensively affect cellular function and metabolism; yet "free" heme in sufficient amounts can be damaging to the kidney and other organs because of its bioreactivity and pro-oxidant effects. This review discusses the cellular metabolism of heme in health and disease and covers such areas as the synthesis of heme and its utilization in heme proteins; mechanisms underlying the toxicity of heme; and the extent to which pathophysiologic processes, such as renal incorporation of heme proteins or destabilization of intracellular heme proteins, increase intracellular levels of heme and provoke renal injury. The main catabolic process that degrades heme, the heme oxygenase (HO) system, is reviewed, and evidence for the protective effects of HO-1 against acute and chronic heme/heme protein-induced renal injury is summarized. Finally, current views regarding the molecular basis for heme-induced upregulation of HO-1 are discussed.
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Cites
Identification of an Intestinal Heme Transporter
Shayeghi, M., Latunde-Dada, G. O., Oakhill, J. S., Laftah, A. H., Takeuchi, K., Halliday, N., Khan, Y., Warley, A., McCann, F. E., Hider, R. C., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.025 · Cited by 755 · cited 1×
“Conclusion Current understanding of the cellular physiology of heme in the kidney is inchoate, and the following are among the areas that require elucidation: Characterization of heme metabolism in glomeruli and specific nephron segments; the levels of free, uncommitted heme in healthy kidney cells; the manner by whic…”
BackgroundHemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene
Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., Tashiro, S., Takahashi, S., Shibahara, S., Alam, J., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf516 · Cited by 637
Self-citationTsiftsoglou, A. S., Tsamadou, A. I., & Papadopoulou, L. C. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.017 · Cited by 281
Cited by
Ruiz, S., Pergola, P. E., Zager, R. A., & Vaziri, N. D. (2013) · Kidney International · doi:10.1038/ki.2012.439 · Cited by 718
Kovtunovych, G., Eckhaus, M. A., Ghosh, M. C., Ollivierre-Wilson, H., & Rouault, T. A. (2010) · Blood · doi:10.1182/blood-2010-03-272138 · Cited by 271
Oxidative stress and the role of redox signalling in chronic kidney disease
Kishi, S., Nagasu, H., Kidokoro, K., & Kashihara, N. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00775-0 · Cited by 267
Camus, S. M., De Moraes, J. A., Bonnin, P., Abbyad, P., Le Jeune, S., Lionnet, F., Loufrani, L., Grimaud, L., Lambry, J.-C., Charue, D., et al. (2015) · Blood · doi:10.1182/blood-2014-07-589283 · Cited by 262
Saraf, S. L., Zhang, X., Kanias, T., Lash, J. P., Molokie, R. E., Oza, B., Lai, C., Rowe, J. H., Gowhari, M., Hassan, J., et al. (2014) · British Journal of Haematology · doi:10.1111/bjh.12690 · Cited by 120
Metadata
- Authors
- Tracz, M. J., Alam, J., & Nath, K. A.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2007-02
- Volume
- 18
- Issue
- 2
- Pages
- 414-420
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2144379673
- Cited by
- 314
- References
- 3
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tracz, M. J., Alam, J., & Nath, K. A. (2007). Physiology and Pathophysiology of Heme: Implications for Kidney Disease. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2006080894
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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