The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Sympathetic Activation in Chronic Renal Failure
Abstract
The potential involvement of sympathetic overactivity has been neglected in this population despite accumulating experimental and clinical evidence suggesting a crucial role of sympathetic activation for both progression of renal failure and the high rate of cardiovascular events in patients with chronic kidney disease. The contribution of sympathetic neural mechanisms to the occurrence of cardiac arrhythmias, the development of hypertension, and the progression of heart failure are well established; however, the exact mechanisms contributing to heightened sympathetic tone in patients with chronic kidney disease are unclear. This review analyses potential mechanisms underlying sympathetic activation in chronic kidney disease, the range of adverse consequences associated with this activation, and potential therapeutic implications resulting from this relationship.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Sympathetic nervous system activation is present in patients with chronic kidney disease, intimated first with the finding of elevated plasma norepinephrine concentrations100–101, then more definitively with demonstration of whole-body norepinephrine spillover measurements and increased sympathetic nerve firing recorded with clinical microneurography48–51,102.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [102]
Citations
Cites
Blood Pressure and End-Stage Renal Disease in Men
Klag, M. J., Whelton, P. K., Randall, B. L., Neaton, J. D., Brancati, F. L., Ford, C. E., Shulman, N. B., & Stamler, J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601043340103 · Cited by 1,661
Sympathetic Overactivity in Patients with Chronic Renal Failure
Converse, R. L., Jacobsen, T. N., Toto, R. D., Jost, C. M. T., Cosentino, F., Fouad-Tarazi, F., & Victor, R. G. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272704 · Cited by 1,132
Neural Control of Renal Function*
Kopp, U. C., & DiBona, G. F. (2020) · Reflex Control of the Circulation · doi:10.1201/9780367813338-17 · Cited by 1,126
Poor Long-Term Survival after Acute Myocardial Infarction among Patients on Long-Term Dialysis
Herzog, C. A., Ma, J. Z., & Collins, A. J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809173391203 · Cited by 881
End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions
Ritz, E., Rychlík, I., Locatelli, F., & Halimi, S. (1999) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(99)70035-1 · Cited by 811
Prevalence of High Blood Pressure and Elevated Serum Creatinine Level in the United States
Coresh, J., Wei, G. L., McQuillan, G. M., Brancati, F., Levey, A. S., Jones, C. A., & Klag, M. J. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.9.1207 · Cited by 579
Preeclampsia — A State of Sympathetic Overactivity
Schobel, H. P., Fischer, T., Heusser, K., Geiger, H., & Schmieder, R. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199611143352002 · Cited by 556
Reid, I. A. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.6.e763 · Cited by 553
Carvedilol increases two-year survivalin dialysis patients with dilated cardiomyopathy
Cice, G., Ferrara, L., D’Andrea, A., D’Isa, S., Benedetto, A. D., Cittadini, A., Russo, P. E., Golino, P., & Calabrò, R. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00241-9 · Cited by 534
Zoccali, C., Mallamaci, F., Parlongo, S., Cutrupi, S., Benedetto, F. A., Tripepi, G., Bonanno, G., Rapisarda, F., Fatuzzo, P., Seminara, G., et al. (2002) · Circulation · doi:10.1161/hc1102.105261 · Cited by 519
Cited by
Sorted by citations
Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,794
Krum, H., Schlaich, M., Whitbourn, R., Sobotka, P. A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60566-3 · Cited by 2,108
Self-citationCalkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · EP Europace · doi:10.1093/europace/eux274 · Cited by 1,203
Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease
Malpas, S. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00007.2009 · Cited by 696
Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease
Matsushita, K., Ballew, S. H., Wang, A. Y.-M., Kalyesubula, R., Schäeffner, E., & Agarwal, R. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00616-6 · Cited by 728
Metadata
- Authors
- Schlaich, M. P., Socratous, F., Hennebry, S., Eikelis, N., Lambert, E. A., Straznicky, N., Esler, M. D., & Lambert, G. W.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Schlaich, Markus P.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2009-05
- Volume
- 20
- Issue
- 5
- Pages
- 933-939
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2150333966
- Cited by
- 408
- References
- 77
- Citations by year
- 2025: 12 · 2024: 12 · 2023: 25 · 2022: 14 · 2021: 17 · 2020: 20 · 2019: 25 · 2018: 17 · 2017: 36 · 2016: 34 · 2015: 21 · 2014: 32 · 2013: 44 · 2012: 35
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- sympathetic activation, chronic kidney disease, sympathetic hyperactivity, cardiovascular events, cardiac arrhythmias, hypertension, heart failure, renal failure progression, therapeutic target
- MeSH terms
- Animals, Cardiovascular Diseases, Catecholamines, Clonidine, Debrisoquin, Disease Models, Animal, Efferent Pathways, Humans, Hypertension, Kidney, Kidney Failure, Chronic, Monoamine Oxidase, Nerve Fibers, Nitric Oxide, Norepinephrine, Sympathetic Nervous System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
