The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Phosphorus Binders and Survival on Hemodialysis
Open accessAbstract
Although hyperphosphatemia is a risk factor for mortality, there are limited data on whether therapy with phosphorus binders affects survival. We analyzed a prospective cohort study of 10,044 incident hemodialysis patients using Cox proportional hazards analyses to compare 1-yr all-cause mortality among patients who were or were not treated with phosphorus binders. We performed intention-to-treat analyses to compare patients who began treatment with phosphorus binders during the first 90 d after initiating hemodialysis (n = 3555) with those who remained untreated during that period (n = 5055). We also performed as-treated analyses that modeled phosphorus binder treatment as a time-dependent exposure. We compared survival in a subcohort of treated (n = 3186) and untreated (n = 3186) patients matched by their baseline serum phosphate levels and propensity score of receiving phosphorus binders during the first 90 d. One-year mortality was 191 deaths/1000 patient-years at risk. Treatment with phosphorus binders was independently associated with decreased mortality compared with no treatment in the intention-to-treat, as-treated, and matched analyses. The results were independent of baseline and follow-up serum phosphate levels and persisted in analyses that excluded deaths during the first 90 d of hemodialysis. In summary, treatment with phosphorus binders is independently associated with improved survival among incident hemodialysis patients. Although confirmatory studies are needed in the dialysis setting, future placebo-controlled, randomized trials of phosphorus binders might focus on predialysis patients with chronic kidney disease and normal serum phosphate levels.
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Cites
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
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Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis
Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh-Hain, J. A., Tamez, H., Shah, A., Smith, K., Lee, H., Thadhani, R., Jüppner, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706130 · Cited by 1,727
Self-citationSevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients
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Cited by
Isakova, T. (2011) · JAMA · doi:10.1001/jama.2011.826 · Cited by 1,020
Self-citationHu, M. C., Shiizaki, K., Kuro-o, M., & Moe, O. W. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183727 · Cited by 587
FGF-23 Associates with Death, Cardiovascular Events, and Initiation of Chronic Dialysis
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Mechanistic Insights into Vascular Calcification in CKD
Shroff, R., Long, D. A., & Shanahan, C. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011121191 · Cited by 396
Metadata
- Authors
- Isakova, T., Gutie[Combining Acute Accent]rrez, O. M., Chang, Y., Shah, A., Tamez, H., Smith, K., Thadhani, R., & Wolf, M.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2009-02
- Volume
- 20
- Issue
- 2
- Pages
- 388-396
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2150640826
- Cited by
- 375
- References
- 37
- FWCI
- 20.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Isakova, T., Gutie[Combining Acute Accent]rrez, O. M., Chang, Y., Shah, A., Tamez, H., Smith, K., Thadhani, R., & Wolf, M. (2009). Phosphorus Binders and Survival on Hemodialysis. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2008060609
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