The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Mechanistic Insights into Vascular Calcification in CKD
Abstract
Cardiovascular disease begins early in the course of renal decline and is a life-limiting problem in patients with CKD. The increased burden of cardiovascular disease is due, at least in part, to calcification of the vessel wall. The uremic milieu provides a perfect storm of risk factors for accelerated calcification, but elevated calcium and phosphate levels remain key to the initiation and progression of vascular smooth muscle cell calcification in CKD. Vascular calcification is a highly regulated process that involves a complex interplay between promoters and inhibitors of calcification and has many similarities to bone ossification. Here, we discuss current understanding of the process of vascular calcification, focusing specifically on the discrete and synergistic effects of calcium and phosphate in mediating vascular smooth muscle cell apoptosis, osteochondrocytic differentiation, vesicle release, calcification inhibitor expression, senescence, and death. Using our model of intact human vessels, factors initiating vascular calcification in vivo and the role of calcium and phosphate in driving accelerated calcification ex vivo are described. This work allows us to link clinical and basic research into a working theoretical model to explain the pathway of development of vascular calcification in CKD.
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Cites
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Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
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Cited by
Madhavan, M. V., Tarigopula, M., Mintz, G. S., Maehara, A., Stone, G. W., & Généreux, P. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.017 · Cited by 579
Kramann, R., Goettsch, C., Wongboonsin, J., Iwata, H., Schneider, R. K., Kuppe, C., Kaesler, N., Chang-Panesso, M., Machado, F. G., Gratwohl, S., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.08.001 · Cited by 308
Metadata
- Authors
- Shroff, R., Long, D. A., & Shanahan, C.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2013-02
- Volume
- 24
- Issue
- 2
- Pages
- 179-189
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2166199725
- Cited by
- 396
- References
- 95
- FWCI
- 15.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shroff, R., Long, D. A., & Shanahan, C. (2013). Mechanistic Insights into Vascular Calcification in CKD. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2011121191
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
