The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging
Open accessAbstract
Interstitial fibrosis and hypoxia accelerate the progression of CKD, but clinical tools to quantitate these factors in patients are lacking. Here, we evaluated the use of two magnetic resonance imaging (MRI) techniques, diffusion-weighted (DW)-MRI and blood oxygen level-dependent (BOLD)-MRI, to assess kidney fibrosis and hypoxia of the cortex in 142 patients with either diabetic nephropathy (n = 43), CKD without diabetes (n = 76), or acute kidney injury (AKI) (n = 23). Apparent diffusion coefficient (ADC) values of DW-MRI correlated with estimated glomerular filtration rates (eGFR) in the diabetic nephropathy and CKD groups (r(2) = 0.56 and r(2) = 0.46, respectively). Although the T2* values of BOLD-MRI and eGFR displayed good correlation in the CKD group (r(2) = 0.38), we did not observe a significant correlation between these values in the diabetic nephropathy group, suggesting that factors other than tubulointerstitial alteration determine the degree of hypoxia in the renal cortex. In the AKI group, neither the T2* nor ADC values correlated with eGFR. Renal biopsies from patients with CKD demonstrated that the T2* and ADC MRI values correlated with renal pathology. Taken together, ADC and T2* values appear to serve as accurate indices for evaluating renal tubulointerstitial alterations and parenchymal hypoxia, respectively, in the cortex. Functional MRI can thus contribute to multilateral, noninvasive, in vivo assessment of kidney function.
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Cited by
Basile, D. P., Bonventre, J. V., Mehta, R., Nangaku, M., Unwin, R., Rosner, M. H., Kellum, J. A., & Ronco, C. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015030309 · Cited by 431
Hypoxia as a key player in the AKI-to-CKD transition
Tanaka, S., Tanaka, T., & Nangaku, M. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00425.2014 · Cited by 280
Hansell, P., Welch, W. J., Blantz, R. C., & Palm, F. (2013) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12034 · Cited by 269
Hesp, A. C., Schaub, J. A., Prasad, P. V., Vallon, V., Laverman, G. D., Bjornstad, P., & van Raalte, D. H. (2020) · Kidney International · doi:10.1016/j.kint.2020.02.041 · Cited by 202
Hypoxia and its Emerging Therapeutics in Neurodegenerative, Inflammatory and Renal Diseases
Bhatia, D., Ardekani, M. S., Shi, Q., & Movafagh, S. (2017) · Hypoxia and Human Diseases · doi:10.5772/66089 · Cited by 17
Metadata
- Authors
- Inoue, T., Kozawa, E., Okada, H., Inukai, K., Watanabe, S., Kikuta, T., Watanabe, Y., Takenaka, T., Katayama, S., Tanaka, J., & Suzuki, H.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2011-08
- Volume
- 22
- Issue
- 8
- Pages
- 1429-1434
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2109312341
- Cited by
- 344
- References
- 21
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Inoue, T., Kozawa, E., Okada, H., Inukai, K., Watanabe, S., Kikuta, T., Watanabe, Y., Takenaka, T., Katayama, S., Tanaka, J., & Suzuki, H. (2011). Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2010111143
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