The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery
Open accessAbstract
Acute kidney injury (AKI) is a frequent complication of cardiac surgery and increases morbidity and mortality. The identification of reliable biomarkers that allow earlier diagnosis of AKI in the postoperative period may increase the success of therapeutic interventions. Here, we conducted a prospective, multicenter cohort study involving 1219 adults undergoing cardiac surgery to evaluate whether early postoperative measures of urine IL-18, urine neutrophil gelatinase-associated lipocalin (NGAL), or plasma NGAL could identify which patients would develop AKI and other adverse patient outcomes. Urine IL-18 and urine and plasma NGAL levels peaked within 6 hours after surgery. After multivariable adjustment, the highest quintiles of urine IL-18 and plasma NGAL associated with 6.8-fold and 5-fold higher odds of AKI, respectively, compared with the lowest quintiles. Elevated urine IL-18 and urine and plasma NGAL levels associated with longer length of hospital stay, longer intensive care unit stay, and higher risk for dialysis or death. The clinical prediction model for AKI had an area under the receiver-operating characteristic curve (AUC) of 0.69. Urine IL-18 and plasma NGAL significantly improved the AUC to 0.76 and 0.75, respectively. Urine IL-18 and plasma NGAL significantly improved risk prediction over the clinical models alone as measured by net reclassification improvement (NRI) and integrated discrimination improvement (IDI). In conclusion, urine IL-18, urine NGAL, and plasma NGAL associate with subsequent AKI and poor outcomes among adults undergoing cardiac surgery.
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Global epidemiology and outcomes of acute kidney injury
Hoste, E. A. J., Kellum, J. A., Selby, N. M., Zarbock, A., Palevsky, P. M., Bagshaw, S. M., Goldstein, S. L., Cerdá, J., & Chawla, L. S. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0052-0 · Cited by 1,486
Acute kidney injury-epidemiology, outcomes and economics
Rewa, O., & Bagshaw, S. M. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.282 · Cited by 734
The definition of acute kidney injury and its use in practice
Thomas, M. E., Blaine, C., Dawnay, A., Devonald, M. A. J., Ftouh, S., Laing, C., Latchem, S., Lewington, A., Milford, D. V., & Ostermann, M. (2015) · Kidney International · doi:10.1038/ki.2014.328 · Cited by 722
Biomarkers in acute kidney injury – pathophysiological basis and clinical performance
Schrezenmeier, E. V., Barasch, J., Budde, K., Westhoff, T., & Schmidt‐Ott, K. M. (2017) · Acta Physiologica · doi:10.1111/apha.12764 · Cited by 401
Biomarkers of Drug-Induced Kidney Toxicity
Griffin, B. R., Faubel, S., & Edelstein, C. L. (2019) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000589 · Cited by 285
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Metadata
- Authors
- Parikh, C. R., Coca, S. G., Thiessen-Philbrook, H., Shlipak, M. G., Koyner, J. L., Wang, Z., Edelstein, C. L., Devarajan, P., Patel, U. D., Zappitelli, M., Krawczeski, C. D., Passik, C. S., Swaminathan, M., & Garg, A. X.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2011-09
- Volume
- 22
- Issue
- 9
- Pages
- 1748-1757
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2124770381
- Cited by
- 754
- References
- 6
- FWCI
- 44.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Parikh, C. R., Coca, S. G., Thiessen-Philbrook, H., Shlipak, M. G., Koyner, J. L., Wang, Z., Edelstein, C. L., Devarajan, P., Patel, U. D., Zappitelli, M., Krawczeski, C. D., Passik, C. S., Swaminathan, M., & Garg, A. X. (2011). Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2010121302
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