The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease
Open accessAbstract
Mesenchymal stem cell-like (MSC-like) cells reside in the vascular wall but their role in vascular regeneration and disease is poorly understood. Here, we show that Gli1+ cells located in the arterial adventitia are progenitors of vascular smooth muscle cells, and contribute to neointima formation and repair after acute injury to the femoral artery. Genetic fate tracing indicates that adventitial Gli1+ MSC-like cells migrate into the media and neointima during athero- and arteriosclerosis in ApoE−/− mice with chronic kidney disease. Our data indicate that Gli1+ cells are a major source of osteoblast-like cells during calcification in the media and intima. Genetic ablation of Gli1+ cells before induction of kidney injury dramatically reduced the severity of vascular calcification. These findings implicate Gli1+ cells as critical adventitial progenitors in vascular remodeling after acute and during chronic injury and suggest that they may be relevant therapeutic targets for mitigation of vascular calcification.
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Citations
Cites
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“A classical hypothesis holds that in response to injury, terminally differentiated vSMCs undergo a phenotypic switch, downregulating contractile proteins and proliferating and migrating into the neointima (Tabas et al., 2015).”
BackgroundPerivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
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Cited by
Mesenchymal stem cell perspective: cell biology to clinical progress
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Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation
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Metadata
- Authors
- Kramann, R., Goettsch, C., Wongboonsin, J., Iwata, H., Schneider, R. K., Kuppe, C., Kaesler, N., Chang-Panesso, M., Machado, F. G., Gratwohl, S., Madhurima, K., Hutcheson, J. D., Jain, S., Aikawa, E., & Humphreys, B. D.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 19
- Issue
- 5
- Pages
- 628-642
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2519920776
- Cited by
- 308
- References
- 53
- FWCI
- 22.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kramann, R., Goettsch, C., Wongboonsin, J., Iwata, H., Schneider, R. K., Kuppe, C., Kaesler, N., Chang-Panesso, M., Machado, F. G., Gratwohl, S., Madhurima, K., Hutcheson, J. D., Jain, S., Aikawa, E., & Humphreys, B. D. (2016). Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease. Cell Stem Cell. https://doi.org/10.1016/j.stem.2016.08.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
