The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease
Open accessAbstract
Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with an abnormal extracellular matrix and alternatively activated interstitial macrophages, and the disruption of mechanisms controlling tubular diameter contribute to cyst formation. Studies with animal models suggest that several diverse pathophysiologic mechanisms, including dysregulation of intracellular calcium levels and cAMP signaling, mediate these cystogenic mechanisms. This article reviews the evidence implicating calcium and cAMP as central players in a network of signaling pathways underlying the pathogenesis of PKD and considers the therapeutic relevance of treatment strategies targeting cAMP signaling.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Spirlı̀, C., Morell, C. M., Locatelli, L., Okolicsanyi, S., Ferrero, C., Kim, A. K., Fabris, L., Fiorotto, R., & Strazzabosco, M. (2012) · Hepatology · doi:10.1002/hep.25872 · Cited by 58
RetractedSontrop, J. M., Dixon, S. N., Garg, A. X., Buendia-Jimenez, I., Dohein, O., Huang, S.-H. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,871
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383
Identification and proteomic profiling of exosomes in human urine
Pisitkun, T., Shen, R.-F., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,174
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020
Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease
Torres, V. E., Chapman, A. B., Devuyst, O., Gansevoort, R. T., Grantham, J. J., Higashihara, E., Perrone, R. D., Krasa, H. B., Ouyang, J., & Czerwiec, F. S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1205511 · Cited by 1,614
Self-citationMacrophages, innate immunity and cancer: balance, tolerance, and diversity
Mantovani, A., & Sica, A. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.009 · Cited by 1,484
Distinct macrophage phenotypes contribute to kidney injury and repair
Lee, S., Huen, S., Nishio, H., Nishio, S., Lee, H. K., Choi, B.-S., Ruhrberg, C., & Cantley, L. G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060615 · Cited by 906
Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O. A., Jenny, A., et al. (2005) · Nature Genetics · doi:10.1038/ng1552 · Cited by 767
Cited by
Autosomal dominant polycystic kidney disease
Cornec-Le Gall, E., Alam, A., & Perrone, R. D. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32782-x · Cited by 624
Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease
Harris, P. C., & Torres, V. E. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72272 · Cited by 338
Self-citationOrganoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery
Hiratsuka, K., Miyoshi, T., Kroll, K. T., Gupta, N. R., Valerius, M. T., Ferrante, T., Yamashita, M., Lewis, J. A., & Morizane, R. (2022) · Science Advances · doi:10.1126/sciadv.abq0866 · Cited by 140
Wang, Q., Cobo-Stark, P., Patel, V., Somlo, S., Han, P.-L., & Igarashi, P. (2018) · Kidney International · doi:10.1016/j.kint.2017.08.005 · Cited by 52
“Tolvaptan is now approved for the treatment of ADPKD in some countries, although it has not been approved for this indication in the United States.(16) The mechanism whereby cAMP is elevated in PKD remains poorly understood.”
BackgroundTGR5 in the Cholangiociliopathies
Masyuk, T. V., Masyuk, A. I., & LaRusso, N. F. (2015) · Digestive Diseases · doi:10.1159/000371696 · Cited by 29
Metadata
- Authors
- Torres, V. E., & Harris, P. C.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2014-01
- Volume
- 25
- Issue
- 1
- Pages
- 18-32
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2107890949
- Cited by
- 289
- References
- 145
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease. https://app.cochat.ai/papers/10.1681/asn.2013040398
- The paper
- Torres, V. E., & Harris, P. C. (2014). Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2013040398
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
