The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Mitochondria in Sepsis-Induced AKI
Open accessAbstract
AKI is a common clinical condition associated with the risk of developing CKD and ESKD. Sepsis is the leading cause of AKI in the intensive care unit (ICU) and accounts for nearly half of all AKI events. Patients with AKI who require dialysis have an unacceptably high mortality rate of 60%–80%. During sepsis, endothelial activation, increased microvascular permeability, changes in regional blood flow distribution with resulting areas of hypoperfusion, and hypoxemia can lead to AKI. No effective drugs to prevent or treat human sepsis-induced AKI are currently available. Recent research has identified dysfunction in energy metabolism as a critical contributor to the pathogenesis of AKI. Mitochondria, the center of energy metabolism, are increasingly recognized to be involved in the pathophysiology of sepsis-induced AKI and mitochondria could serve as a potential therapeutic target. In this review, we summarize the potential role of mitochondria in sepsis-induced AKI and identify future therapeutic approaches that target mitochondrial function in an effort to treat sepsis-induced AKI.
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Cites
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Cited by
Sepsis-Associated Acute Kidney Injury
Manrique-Caballero, C. L., Del Rio-Pertuz, G., & Gomez, H. (2021) · Critical Care Clinics · doi:10.1016/j.ccc.2020.11.010 · Cited by 312
Mitochondria: It is all about energy
Casanova, A., Wevers, A., Navarro-Ledesma, S., & Pruimboom, L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1114231 · Cited by 303
The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases
Fontecha-Barriuso, M., Martin-Sanchez, D., Martinez-Moreno, J., Monsalve, M., Ramos, A., Sanchez-Niño, M., Ruiz-Ortega, M., Ortiz, A., & Sanz, A. (2020) · Biomolecules · doi:10.3390/biom10020347 · Cited by 294
Metadata
- Authors
- Sun, J., Zhang, J., Tian, J., Virzì, G. M., Digvijay, K., Cueto, L., Yin, Y., Rosner, M. H., & Ronco, C.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2019-05-10
- Volume
- 30
- Issue
- 7
- Pages
- 1151-1161
- ISSN
- 1046-6673 (ISSN-L)
- 1533-3450
- OpenAlex
- W2944370458
- Cited by
- 257
- References
- 107
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mitochondria in Sepsis-Induced AKI. https://app.cochat.ai/papers/10.1681/asn.2018111126
- The paper
- Sun, J., Zhang, J., Tian, J., Virzì, G. M., Digvijay, K., Cueto, L., Yin, Y., Rosner, M. H., & Ronco, C. (2019). Mitochondria in Sepsis-Induced AKI. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2018111126
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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