Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney
Abstract
Abstract.: Lipid abnormalities are associated with various disorders ranging from generalized atherosclerosis to renal diseases, including lipoprotein glomerulopathy that is characterized by glomerular lipoprotein thrombi and causes type III hyperlipoproteinemia, proteinuria, and renal failure. This study examines lipoprotein glomerulopathy, which recurred in a transplanted kidney. Molecular biologic analysis of the patient's apolipoprotein (apo) E gene demonstrated E2/E5 type variants. Immunohistochemical analysis of the diseased kidney demonstrated various lipid peroxidation-specific protein adducts, suggesting a potential role of oxidative stress in this disorder. Recurrence in the transplanted kidney suggested a pathogenic role of extraglomerular humoral component(s) resulting from abnormal lipoprotein metabolism, presumably linked to apo E and other genetic or acquired factor(s). Furthermore, the finding that the patient showed pathologic abnormalities in the transplanted kidney with no clinical signs or symptoms of renal disease indicated that lipoprotein glomerular damage progresses early before any clinical manifestations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LPG relapse following kidney transplantation suggests that factors outside the kidney are crucial for LPG pathogenesis.
“The relapse of LPG following kidney transplantation in LPG patients (3,4) has suggested that factors outside the kidney should be crucial for the disease pathogenesis.”
From Thermodynamic destabilization and aggregation propensity as the mechanism behind the association of apoE3 mutants and lipoprotein glomerulopathy (2018) · cites this paper as [4]
Only two cases of LPG with apoE5 (Glu3Lys) have been reported, and they were confirmed to have apoE-Chicago.
“To the best of our knowledge, only two cases of LPG with apoE5 (Glu3Lys) have been reported [5,6] and these are confirmed to have apoE-Chicago by Kodera [5] (Table 1).”
From A case of lipoprotein glomerulopathy with a rare apolipoprotein E isoform combined with neurofibromatosis type I (2018) · cites this paper as [6]
Cites
Horie, K., Miyata, T., Maeda, K., Miyata, S., Sugiyama, S., Sakai, H., van Ypersole de Strihou, C., Monnier, V. M., Witztum, J. L., & Kurokawa, K. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119853 · Cited by 433 · see citing works
Self-citationRenal catabolism of advanced glycation end products: the fate of pentosidine
Miyata, T., Ueda, Y., Horie, K., Nangaku, M., Tanaka, S., de Strihou, C. V. Y., & Kurokawa, K. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00756.x · Cited by 227 · see citing works
Lipoprotein Glomerulopathy: Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia
Saito, T., Sato, H., Kudo, K.-I., Oikawa, S.-I., Shibata, T., Hara, Y., Yoshinaga, K., & Sakaguchi, H. (1989) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(89)80134-9 · Cited by 148 · see citing works
Abnormal Lipoprotein and Apolipoprotein Pattern in Lipoprotein Glomerulopathy
Oikawa, S., Suzuki, N., Sakuma, E., Saito, T., Namai, K., Kotake, H., Fujii, Y., & Toyota, T. (1991) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80649-4 · Cited by 60 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
APOE gene variants in primary dyslipidemia
Khalil, Y. A., Rabès, J.-P., Boileau, C., & Varret, M. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.05.007 · Cited by 170 · see citing works
Apolipoprotein E–related glomerular disorders
Saito, T., Matsunaga, A., Fukunaga, M., Nagahama, K., Hara, S., & Muso, E. (2020) · Kidney International · doi:10.1016/j.kint.2019.10.031 · Cited by 77 · see citing works
Tsimihodimos, V., & Elisaf, M. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328345ebb0 · Cited by 33 · see citing works
Katsarou, M., Stratikos, E., & Chroni, A. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m088732 · Cited by 22 · see citing works
Takasaki, S., Matsunaga, A., Joh, K., & Saito, T. (2018) · CEN Case Reports · doi:10.1007/s13730-018-0309-2 · Cited by 7 · see citing works
Li, Y., Chen, J., Zou, Y., Wang, W., & Li, G. (2022) · Medicine · doi:10.1097/md.0000000000028718 · Cited by 5 · see citing works
A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation
Liu, Y., Cheng, Y., Wen, Y., Li, C., Chen, G., & Li, M. (2024) · BMC Nephrology · doi:10.1186/s12882-024-03515-z · Cited by 2 · see citing works
Identification of a founder haplotype of <i>APOE Kyoto</i> variant in lipoprotein glomerulopathy
Wu, H., He, Z., Yang, J., Zhou, Y., Yang, Z., Hu, Z., & Yang, Y. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf234
- Authors
- MIYATA, T., SUGIYAMA, S., NANGAKU, M., SUZUKI, D., URAGAMI, K.-I., INAGI, R., SAKAI, H., & KUROKAWA, K.
- Affiliations
- Tokai University (JP)
- Corresponding author
- MIYATA, TOSHIO
- NANGAKU, MASAOMI
- SUZUKI, DAISUKE
- URAGAMI, KEN-ICHI
- INAGI, REIKO
- SAKAI, HIDETO
- KUROKAWA, KIYOSHI
- Venue
- Journal of the American Society of Nephrology
- Published
- 1999-07
- Volume
- 10
- Issue
- 7
- Pages
- 1590-1595
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2149057126
- Cited by
- 55
- References
- 4
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- lipoprotein glomerulopathy, apolipoprotein E, kidney transplantation, type III hyperlipoproteinemia, lipid peroxidation, oxidative stress, proteinuria, renal failure, lipoprotein metabolism
- MeSH terms
- Adult, Apolipoproteins E, Base Sequence, Humans, Kidney Diseases, Kidney Glomerulus, Male, Polymorphism, Restriction Fragment Length, Genetic Variation, Lipid Peroxidation, Kidney Transplantation, DNA Primers, Apolipoprotein E2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
