The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Impaired Angiogenesis in the Remnant Kidney Model: I. Potential Role of Vascular Endothelial Growth Factor and Thrombospondin-1
Abstract
Abstract.: Few studies have examined the role of the microvasculature in progressive renal disease. It was hypothesized that impaired angiogenesis might occur in the diseased kidney and could contribute to renal scarring. Progressive renal disease was induced in rats by 5/6 renal ablation and those rats were compared with sham-operated control animals at multiple time points, for examination of changes in the microvasculature and the expression of angiogenic factors. An early angiogenic response was documented in remnant kidneys, with increases in the proliferation of peritubular (1 wk) and glomerular (2 wk) endothelial cells. Subsequently, however, there was a decrease in endothelial cell proliferation, which was reduced to levels below those of sham-treated animals, in conjunction with interstitial expression of the antiangiogenic factor thrombospondin-1 (TSP-1) and decreased tubular expression of the proangiogenic factor vascular endothelial growth factor (VEGF). Both the increase in TSP-1 expression and the loss of VEGF expression were correlated with capillary loss and the development of glomerulosclerosis and interstitial fibrosis. Progressive macrophage infiltration was correlated both spatially and quantitatively with the sites of absent or diminished VEGF expression. In addition, macrophage-associated cytokines (interleukin-1β, interleukin-6, and tumor necrosis factor-α) inhibited VEGF mRNA expression and protein secretion by cultured tubular epithelial cells of the medullary thick ascending limb, under both normoxic and hypoxic conditions. Impaired angiogenesis characterizes the remnant kidney model and is correlated with progression. The impaired angiogenesis may be mediated by alterations in the renal expression of TSP-1 and VEGF, with the latter being regulated by macrophage-associated cytokines.
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Role of vascular endothelial growth factor in the regulation of angiogenesis
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Self-citationAngiotensin II Induces Apoptosis of Human Endothelial Cells: Protective Effect of Nitric Oxide
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Cited by
A Role for Uric Acid in the Progression of Renal Disease
Kang, D.-H., Nakagawa, T., Feng, L., Watanabe, S., Han, L., Mazzali, M., Truong, L., Harris, R., & Johnson, R. J. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000034910.58454.fd · Cited by 1,304
Self-citationRenal tubule injury: a driving force toward chronic kidney disease
Liu, B.-C., Tang, T.-T., Lv, L.-L., & Lan, H.-Y. (2018) · Kidney International · doi:10.1016/j.kint.2017.09.033 · Cited by 913
Sugimoto, H., Hamano, Y., Charytan, D., Cosgrove, D., Kieran, M., Sudhakar, A., & Kalluri, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300012200 · Cited by 538
The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function
Basile, D. P. (2007) · Kidney International · doi:10.1038/sj.ki.5002312 · Cited by 484
Role of the Microvascular Endothelium in Progressive Renal Disease
Kang, D.-H., Kanellis, J., Hugo, C., Truong, L., Anderson, S., Kerjaschki, D., Schreiner, G. F., & Johnson, R. J. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v133806 · Cited by 466
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Metadata
- Authors
- KANG, D.-H., JOLY, A. H., OH, S.-W., HUGO, C., KERJASCHKI, D., GORDON, K. L., MAZZALI, M., JEFFERSON, J. A., HUGHES, J., MADSEN, K. M., SCHREINER, G. F., & JOHNSON, R. J.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2001-07
- Volume
- 12
- Issue
- 7
- Pages
- 1434-1447
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2168574106
- Cited by
- 411
- References
- 38
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- KANG, D.-H., JOLY, A. H., OH, S.-W., HUGO, C., KERJASCHKI, D., GORDON, K. L., MAZZALI, M., JEFFERSON, J. A., HUGHES, J., MADSEN, K. M., SCHREINER, G. F., & JOHNSON, R. J. (2001). Impaired Angiogenesis in the Remnant Kidney Model: I. Potential Role of Vascular Endothelial Growth Factor and Thrombospondin-1. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.v1271434
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
