The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Role of the Microvascular Endothelium in Progressive Renal Disease
Abstract
The role of the vascular endothelium in progressive renal disease is not well understood. This review presents evidence that progressive renal disease is characterized by a progressive loss of the microvasculature. The loss of the microvasculature correlates directly with the development of glomerular and tubulointerstitial scarring. The mechanism is mediated in part by a reduction in the endothelial proliferative response, and this impairment in capillary repair is mediated by alteration in the local expression of both angiogenic (vascular endothelial growth factor) and antiangiogenic (thrombospondin 1) factors in the kidney. The alteration in balance of angiogenic growth factors is mediated by both macrophage-associated cytokines (interleukin-1beta) and vasoactive mediators. Finally, there is intriguing evidence that stimulation of angiogenesis and/or capillary repair may stabilize renal function and slow progression and that this benefit occurs independently of effects on BP or proteinuria. Therefore, angiogenic agents may represent a novel therapeutic approach for slowing the progression of renal disease.
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Cites
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Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries
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Cited by
Fine, L. G., & Norman, J. T. (2008) · Kidney International · doi:10.1038/ki.2008.350 · Cited by 515
Renal Dysfunction Complicating the Treatment of Hypertension
Palmer, B. F. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020676 · Cited by 326
Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis
Evans, R. G., Gardiner, B. S., Smith, D. W., & O'Connor, P. M. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90230.2008 · Cited by 274
. Prediction, progression and outcomes of chronic kidney disease in older adults.
Anderson, S., Halter, J. B., Hazzard, W. R., Himmelfarb, J., Horne, F. M., Kaysen, G. A., Kusek, J. W., Nayfield, S. G., Schmader, K., Tian, Y., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008080860 · Cited by 218
Self-citationThompson, C. S., & Hakim, A. M. (2009) · Stroke · doi:10.1161/strokeaha.108.542266 · Cited by 208
Metadata
- Authors
- Kang, D.-H., Kanellis, J., Hugo, C., Truong, L., Anderson, S., Kerjaschki, D., Schreiner, G. F., & Johnson, R. J.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2002-03
- Volume
- 13
- Issue
- 3
- Pages
- 806-816
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2129859917
- Cited by
- 466
- References
- 79
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kang, D.-H., Kanellis, J., Hugo, C., Truong, L., Anderson, S., Kerjaschki, D., Schreiner, G. F., & Johnson, R. J. (2002). Role of the Microvascular Endothelium in Progressive Renal Disease. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.v133806
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
