The Effect of Theophylline on the Prevention of Mechanical Ventilation-Induced Diaphragm Atrophy in Rats
Open accessAbstract
BACKGROUND: Movement disorders and atrophy occur in the diaphragm, the most important muscle of respiration, because of mechanical ventilation (MV). OBJECTIVES: In this animal model, we aimed to evaluate the effect of intravenous theophylline administration on the prevention of mechanical ventilation-induced diaphragmatic atrophy. MATERIAL AND METHODS: In our study, 30 healthy male Sprague-dawley rats were used. They were divided into 3 equal groups. Group 1: the control group (no MV); group 2: the placebo group that received MV; Group 3: the theophylline group composed of rats that received both MV and theophylline therapy. In all 3 groups, the diaphragmatic atrophy was evaluated histopathologically. RESULTS: In the histopathological examination, no macroscopic thickening and microscopic atrophy were observed in the diaphragm in the control group. In the placebo group (group 2), macroscopically definite thickening was observed in all rats, and microscopically, heavy (+++) atrophy was observed. In the theophylline group (group 3), there was no atrophy in one rat. In 8 rats, light (+), and in 1 rat medium (++) atrophy was observed. CONCLUSIONS: In our study, it was shown that atrophy occurred in the diaphragms of rats after MV, and the atrophy was decreased after theophylline administration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Theophylline reverses the muscle atrophy induced by 28 weeks of cigarette smoke exposure via suppressing the inflammatory effect, upregulating histone deacetylase 2 expression, and inhibiting the activation of NF-κB and p65 in Kunming mice model.
“Theophylline reverses the muscle atrophy induced by 28 weeks of cigarette smoke exposure via suppressing the inflammatory effect, upregulating histone deacetylase 2 expression, and inhibiting the activation of NF-κB and p65 in Kunming mice model [139,142].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [142]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A Comparison of Four Methods of Weaning Patients from Mechanical Ventilation
Esteban, A., Frutos–Vivar, F., Tobin, M. J., Alía, I., Solsona, J. F., Valverdu, V., Fernández, R., de la Cal, M. A., Benito, S., Tomás, R., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502093320601 · Cited by 1,542 · see citing works
Aminophylline Improves Diaphragmatic Contractility
Aubier, M., Troyer, A. D., Sampson, M. G., Macklem, P. T., & Roussos, C. (1981) · New England Journal of Medicine · doi:10.1056/nejm198107303050503 · Cited by 398 · see citing works
Shanely, R. A., Zergeroğlu, A. M., Lennon, S. L., Sugiura, T., Yimlamai, T., Enns, D., BELCASTRO, A. N., & Powers, S. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200202-088oc · Cited by 348 · see citing works
Assist–Control Mechanical Ventilation Attenuates Ventilator-induced Diaphragmatic Dysfunction
Sassoon, C. S. H., Zhu, E., & Caiozzo, V. J. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200401-042oc · Cited by 325 · see citing works
Mechanical ventilation results in progressive contractile dysfunction in the diaphragm
Powers, S. K., Shanely, R. A., Coombes, J. S., Koesterer, T. J., McKenzie, M., Gammeren, D. V., Cicale, M. J., & DODD, S. L. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00881.2001 · Cited by 319 · see citing works
Murciano, D., Aubier, M., Lecocguic, Y., et al. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408093110601 · Cited by 287 · see citing works
Effects of Mechanical Ventilation on Diaphragmatic Contractile Properties in Rats
Bourdellés, G. L., Viirès, N., Boczkowski, J., Séta, N., Pavlović, D., & Aubier, M. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.6.8004310 · Cited by 275 · see citing works
Human respiratory muscles: fibre morphology and capillary supply
Mizuno, M. (1991) · European Respiratory Journal · doi:10.1183/09031936.93.04050587 · Cited by 146 · see citing works
Effects of mechanical ventilation on diaphragm function and biology
Gayan‐Ramirez, G., & Decramer, M. L. A. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00063102 · Cited by 106 · see citing works
Mechanism of respiratory effects of methylxanthines
Eldridge, F. L., Millhorn, D. E., Waldrop, T. G., et al. (1983) · Respiration Physiology · doi:10.1016/0034-5687(83)90070-1 · Cited by 92 · see citing works
Low-Frequency Fatigue in Isolated Skeletal Muscles and the Effects of Methylxanthines
Jones, D. A., Howell, S., Roussos, C., & Edwards, R. H. T. (1982) · Clinical Science · doi:10.1042/cs0630161 · Cited by 91 · see citing works
Current Options in the Management of Apnea of Prematurity
Bhatia, J. J. S. (2000) · Clinical Pediatrics · doi:10.1177/000992280003900602 · Cited by 78 · see citing works
The effect of aminophylline on inspiratory muscle contractility.
Sigrist, S., Thomas, D., Howell, S., et al. (1982) · PubMed · doi:10.1164/arrd.1982.126.1.46 · Cited by 68 · see citing works
Effect of aminophylline and isoproterenol on spinal cord blood flow after impact injury
Dow-Edwards, D. L., DeCrescito, V., Tomasula, J. J., et al. (1980) · Journal of neurosurgery · doi:10.3171/jns.1980.53.3.0385 · Cited by 38 · see citing works
Myosin phenotype and bioenergetic characteristics of rat respiratory muscles
Powers, S. K., Demirel, H. A., Coombes, J. S., Fletcher, L., CALLIAUD, C., Vrabas, I. S., & Prezant, D. J. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199712000-00005 · Cited by 38 · see citing works
Kentera, D., & Varagić, V. M. (1975) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1975.tb07578.x · Cited by 37 · see citing works
Viirès, N., Aubier, M., Murciano, D., et al. (1986) · PubMed · doi:10.1164/arrd.1986.133.6.1060 · Cited by 30 · see citing works
The Effect of Aminophylline on the Force-Length Characteristics of the Diaphragm
Wanke, T., Merkle, M., Zifko, U., et al. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.6.8004311 · Cited by 29 · see citing works
Effect of theophylline on diaphragmatic and other skeletal muscle function
Aubier, M. (1986) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(86)90062-x · Cited by 28 · see citing works
Diltiazem, Verapamil, and Nifedipine Inhibit Theophylline-enhanced Diaphragmatic Contractility
Kolbeck, R. C., & Speir, W. A. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/139.1.139 · Cited by 22 · see citing works
Comparative effects of theophylline and adenosine on respiratory skeletal and smooth muscle.
Supinski, G., Ec, D., & Kelsen, S. G. (1986) · PubMed · Cited by 20 · see citing works
Effect of Methylxanthines on Diaphragmatic Fatigue in the Piglet
Mayock, D. E., Standaert, T. A., & Woodrum, D. E. (1992) · Pediatric Research · doi:10.1203/00006450-199211000-00019 · Cited by 15 · see citing works
Theophylline Improves Measurements of Respiratory Muscle Efficiency
Sherman, M. S., Lang, D. M., Matityahu, A., et al. (1996) · CHEST Journal · doi:10.1378/chest.110.6.1437 · Cited by 14 · see citing works
Aminophylline improves diaphragmatic contractility
(1982) · The Indian Journal of Pediatrics · doi:10.1007/bf02752644 · Cited by 13 · see citing works
Effects of Theophylline on Canine Diaphragmatic Contractility and Fatigue
Janssens, S. P., Derom, E., Reid, M. B., et al. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.6.1250 · Cited by 10 · see citing works
Theophylline dilates rat diaphragm arterioles via the prostaglandins pathway
Danialou, G., Vicaut, É., Aubier, M., et al. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701962 · Cited by 9 · see citing works
Kuei, J. H., & Sieck, G. C. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.1.121 · Cited by 7 · see citing works
Theophylline minimally alters contractile properties of canine diaphragm in vitro
Derom, E., Janssens, S. P., de Bock, V., et al. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.69.4.1390 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Aubier M, De Troyer A, Sampson M, Macklem PT, Roussos C: Aminophylline improves diaphragmatic contrac- tility. N Engl J Med 1981, 305, 249-252.
- Aubier M, Murciano D, Viires N, Lecocguic Y, Palacios S, Pariente R: Increased ventilation due to improved diaphragmatic efficiency during aminophylline infusion. Am Rev Respir dis 1983, 127, 148-154.
- Powers S, Demirel H, Coombes J, Fletcher L, Calliaud C, Vrabas I, Prezant D: Myosin phenotype and bioener- getic characteristics of rat respiratory muscle. Med Sci Sports Exerc 1997, 29, 1573-1579.
Cited by
Sorted by citations
Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
- Authors
- Aydin, N. B., Teke, T., Toy, H., & Uzun, K.
- Affiliations
- Necmettin Erbakan University (TR)
- ORCID
- Teke, Turgut
- Venue
- Advances in Clinical and Experimental Medicine
- Publisher
- Wroclaw Medical University
- Published
- 2014-02-28
- Volume
- 23
- Issue
- 1
- Pages
- 33-38
- ISSN
- 1899-5276 (ISSN-L)
- OpenAlex
- W2319925384
- Cited by
- 4
- References
- 28
- Citations by year
- 2023: 1 · 2021: 1 · 2018: 1 · 2015: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Advances in Clinical and Experimental Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- theophylline, diaphragm atrophy, mechanical ventilation, ventilator-induced diaphragm dysfunction, respiratory muscles, muscle atrophy prevention
- MeSH terms
- Animals, Atrophy, Diaphragm, Male, Respiration, Artificial, Theophylline, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
