Relevance of serology for Mycoplasma pneumoniae infection among children with persistent cough
Open accessAbstract
BACKGROUND: Mycoplasma pneumoniae is an important cause of upper and lower respiratory tract infections. Cough and tracheobronchitis are the commonest features of M. pneumoniae infection but diagnosis based on clinical symptoms that may be due to other respiratory pathogens is impossible. Thus laboratory testing for M. pneumoniae is particularly important. Correct and rapid diagnosis of M. pneumoniae infections is of prime importance to introduce appropriate antibiotic treatment. OBJECTIVES: Evaluation of the incidence of IgM and IgG antibodies specific to M. pneumoniae among children with pneumonia and/or chronic cough. MATERIAL AND METHODS: Serum samples from 148 children with a history of chronic cough (lasting at least one month), recurrent respiratory tract infections, allergic rhinitis, and/or inflammatory changes on X-chest ray. First, all sera were screened for specific anti-M. pneumoniae antibodies using agglutination test following the detection of specific IgM and IgG anti-M. pneumoniae antibodies using immunoenzymatic assays. RESULTS: Out of the 148 serum samples, 57 (38.5%) gave positive screening results. However, the presence of M. pneumoniae-specific IgM and/or IgG antibodies was confirmed by immunoenzymatic assays in only 30 (52.6%) of these 57 positive samples. These results indicated that in as many as 27 (47.4%) out of the 57 serum samples screened, false-positive results occurred. CONCLUSIONS: Evaluation of acute- and convalescent-phase sera is necessary to make possible accurate interpretation of the serological testing results.
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IgM serology alone is not a highly specific test and may result in overestimation of infections.
“This, on its own, is not a highly specific test and may result in overestimation of infections.48”
From Co-infections in people with COVID-19: a systematic review and meta-analysis. (2020) · cites this paper as [48]
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- Authors
- Sobieszczańska, B. M., Kasprzykowska, U., Duda-Madej, A., Secewicz, J., & Marciniak, J.
- Affiliations
- Wroclaw Medical University (PL)
- ORCID
- Duda-Madej, Anna
- Venue
- Advances in Clinical and Experimental Medicine
- Publisher
- Wroclaw Medical University
- Published
- 2014-04-30
- Volume
- 23
- Issue
- 2
- Pages
- 185-190
- ISSN
- 1899-5276 (ISSN-L)
- OpenAlex
- W2079096437
- Cited by
- 12
- References
- 21
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Advances in Clinical and Experimental Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- Mycoplasma pneumoniae, serological diagnosis, chronic cough, children, IgM, IgG, false positives, agglutination test, immunoenzymatic assay, acute and convalescent sera, recurrent respiratory infections
- MeSH terms
- Adolescent, Antibodies, Bacterial, Child, Child, Preschool, Chronic Disease, Cough, Humans, Immunoglobulin G, Immunoglobulin M, Immunoenzyme Techniques, Infant, Pneumonia, Mycoplasma
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