Integrating Clinical Research into Epidemic Response: The Ebola Experience
Abstract
The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Republic of Congo (then Zaire) and South Sudan (then Sudan). However, because all Ebola outbreaks prior to that in West Africa in 2014–2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Heath Organization declared the 2014–2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak. Integrating Clinical Research into Epidemic Response: The Ebola Experience assesses the value of the clinical trials held during the 2014–2015 epidemic and makes recommendations about how the conduct of trials could be improved in the context of a future international emerging or re-emerging infectious disease events.
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Input from patient and public contributors and partners can help researchers to identify and prioritise research topics and questions, identify relevant outcome measures, boost recruitment and retention, improve trial design and tools, and improve the ethical acceptability of trial protocols to potential participants.
“Input from the patient and public contributors and partners186 can help researchers to identify and prioritise research topics and questions, identify relevant outcome measures, boost recruitment and retention, improve trial design and tools, and improve the ethical acceptability of trial protocols to potential participants.186 187 188”
From SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials (2025) · cites this paper as [188]
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- Authors
- Committee on Clinical Trials During the 2014-2015 Ebola Outbreak, Board on Global Health, Board on Health Sciences Policy, Division, H. A. M., & National Academies of Sciences, E.
- Venue
- National Academies Press eBooks
- Publisher
- National Academies Press
- Published
- 2017
- OpenAlex
- W2607034258
- Cited by
- 89
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 12 · 2020: 30 · 2019: 8 · 2018: 15 · 2017: 11
- FWCI
- 30.13
- Type
- book
- Language
- en
- Open access
- closed
- Locations
- National Academies Press eBooks (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Health Professions › Emergency Medical Services › Disaster Response and Management
- Keywords
- Ebola virus disease, outbreak response, emerging infectious diseases, re-emerging infectious diseases, public health emergency of international concern, clinical management
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