Cited by 17Cervical Cancer and HPV ResearchColorectal and Anal CarcinomasViral-associated cancers and disorders

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Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

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Iribarren Díaz, Mauricio, Ocampo Hermida, Antonio, González-Carreró Fojón, Joaquín, Longueira Suárez, Rebeca, Rivera Gallego, Alberto, Casal Núñez, Enrique, Ocampo Álvarez, Antón, Cachay, Edward·2017·Revista Española de Enfermedades Digestivas

DOI 10.17235/reed.2017.4274/2016

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Abstract

BACKGROUND: Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain). METHOD: Prospective cohort analysis of 240 HIV-infected MSM. Cellular anal sample and high risk HPV (HR-HPV)-tests were performed to study cytological changes and HPV genotyping. High resolution anoscopy (HRA) was performed in 209 patients. Results were analyzed with respect to epidemiological, clinical and analytical factors. RESULTS: Of 209 patients selected for HRA, the prevalence of HR-HPV anal infection, cytological and histological alterations was 85.6%, 47.5%, and 39.8%, respectively. Sensitivity and specificity for ≥ ASCUS (atypia of squamous cells of undetermined significance) cytology in relation to histological alterations were 61% and 85%, (OR: 8.7; IC 95%: 4.4-17.2), respectively. Observed concordance between high-grade squamous intraepithelial lesion (HSIL) cytology and HSIL anal intraepithelial neoplasia types 2 and 3 (AIN-2/3) histology was 64% (OR: 11.4; IC 95%: 3.6-36.7). One patient with HSIL cytology presented a prevalent anal squamous carcinoma. CONCLUSIONS: HRA was feasible with similar results to relevant groups. There was a high prevalence of anal HR-HPV infection, and cytological and histological alterations.

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Authors: Iribarren Díaz, M., Ocampo Hermida, A., González-Carreró Fojón, J., Longueira Suárez, R., Rivera Gallego, A., Casal Núñez, E., Ocampo Álvarez, A., & Cachay, E.
Affiliations: University of California San Diego (US)
ORCID: Cachay, Edward
Venue: Revista Española de Enfermedades Digestivas
Publisher: Sociedad Espanola de Patologia Digestiva (SEPD)
Published: 2017
Volume: 109
Issue: 4
Pages: 242-249
ISSN: 1130-0108 (ISSN-L)
DOI: 10.17235/reed.2017.4274/2016
OpenAlex: W2624497995
Cited by: 17
References: 37
Citations by year: 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2018: 4 · 2017: 3
FWCI: 1.71
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
Locations: Revista Española de Enfermedades Digestivas (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Scientific Electronic library online (Sciences Carlos III Health Institute) (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Health Sciences › Medicine › Surgery › Colorectal and Anal Carcinomas
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords: anal cancer screening, HIV-infected men who have sex with men, anal human papillomavirus infection, high-risk HPV, anal intraepithelial neoplasia, high-resolution anoscopy, anal cytology, ASCUS, high-grade squamous intraepithelial lesion, HPV genotyping, Vigo
MeSH terms: Adult, Anus Neoplasms, Cross-Sectional Studies, Humans, Male, Mass Screening, Middle Aged, Precancerous Conditions, Prospective Studies, Risk Factors, Sexual Behavior, Cohort Studies, HIV Infections, Prevalence, Homosexuality, Male, Papillomavirus Infections

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Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

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