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Cited by 17Cervical Cancer and HPV ResearchColorectal and Anal CarcinomasViral-associated cancers and disorders

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

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Iribarren Díaz, Mauricio, Ocampo Hermida, Antonio, González-Carreró Fojón, Joaquín, Longueira Suárez, Rebeca, Rivera Gallego, Alberto, Casal Núñez, Enrique, Ocampo Álvarez, Antón, Cachay, Edward·2017·Revista Española de Enfermedades Digestivas
DOI 10.17235/reed.2017.4274/2016
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Abstract

BACKGROUND: Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain). METHOD: Prospective cohort analysis of 240 HIV-infected MSM. Cellular anal sample and high risk HPV (HR-HPV)-tests were performed to study cytological changes and HPV genotyping. High resolution anoscopy (HRA) was performed in 209 patients. Results were analyzed with respect to epidemiological, clinical and analytical factors. RESULTS: Of 209 patients selected for HRA, the prevalence of HR-HPV anal infection, cytological and histological alterations was 85.6%, 47.5%, and 39.8%, respectively. Sensitivity and specificity for ≥ ASCUS (atypia of squamous cells of undetermined significance) cytology in relation to histological alterations were 61% and 85%, (OR: 8.7; IC 95%: 4.4-17.2), respectively. Observed concordance between high-grade squamous intraepithelial lesion (HSIL) cytology and HSIL anal intraepithelial neoplasia types 2 and 3 (AIN-2/3) histology was 64% (OR: 11.4; IC 95%: 3.6-36.7). One patient with HSIL cytology presented a prevalent anal squamous carcinoma. CONCLUSIONS: HRA was feasible with similar results to relevant groups. There was a high prevalence of anal HR-HPV infection, and cytological and histological alterations.

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  1. 8. Frisch M. On the etiology of anal squamous carcinoma. Danish medical bulletin. 2002;49(3):194-209. Epub 2002/09/20.

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Metadata

Authors
Iribarren Díaz, M., Ocampo Hermida, A., González-Carreró Fojón, J., Longueira Suárez, R., Rivera Gallego, A., Casal Núñez, E., Ocampo Álvarez, A., & Cachay, E.
Affiliations
University of California San Diego (US)
ORCID
Cachay, Edward
Venue
Revista Española de Enfermedades Digestivas
Publisher
Sociedad Espanola de Patologia Digestiva (SEPD)
Published
2017
Volume
109
Issue
4
Pages
242-249
ISSN
1130-0108 (ISSN-L)
DOI
10.17235/reed.2017.4274/2016
OpenAlex
W2624497995
Cited by
17
References
37
Citations by year
2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2018: 4 · 2017: 3
FWCI
1.71
Type
journal article
Language
en
Open access
Licence
cc-by-sa
Locations
  • Revista Española de Enfermedades Digestivas (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Scientific Electronic library online (Sciences Carlos III Health Institute) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Surgery › Colorectal and Anal Carcinomas
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
anal cancer screening, HIV-infected men who have sex with men, anal human papillomavirus infection, high-risk HPV, anal intraepithelial neoplasia, high-resolution anoscopy, anal cytology, ASCUS, high-grade squamous intraepithelial lesion, HPV genotyping, Vigo
MeSH terms
Adult, Anus Neoplasms, Cross-Sectional Studies, Humans, Male, Mass Screening, Middle Aged, Precancerous Conditions, Prospective Studies, Risk Factors, Sexual Behavior, Cohort Studies, HIV Infections, Prevalence, Homosexuality, Male, Papillomavirus Infections

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