Role of serum lactic dehydrogenase, glutamic oxaloacetic transaminase, creatine phosphokinase, alkaline phospatase, serum phosphorus in the cases of bowel ischemia in acute abdomen
Open accessAbstract
Background: Bowel ischemia is a life-threatening condition which may arise from a number of causes affecting the arterial and venous compartments of the mesenteric circulation. The rapid onset of acute mesenteric ischemia and the potential rapidity with which bowel infarction may occur explain the lethality of this disease. The aim of this study was to evaluate the role of serum lactic dehydrogenase (LDH), glutamic oxaloacetic transaminase (SGOT), creatine phosphokinase (CPK), alkaline phospatase, serum phosphorus in the cases of bowel ischemia in acute abdomen.Methods: Above mentioned serum enzymes were measured preoperatively in the fifty patients of acute abdomen. Biomarker levels were compared in patients between equal two groups on the basis intra operative findings of bowel ischemia and non-bowel ischemia.Results: Preoperative estimated serum levels of all described enzymes found to be significantly elevated in patients of group A (with bowel ischemia) in comparison with group B (with no bowel ischemia). Sensitivity and specificity for elevated levels of S. LDH were 88% and 68%, for SGOT 68% and 80%, for S. ALP 72% and 68%, for S. CPK-MB 76% and 84%, and for S. phosphorus 76% and 68% respectively.Conclusions: Preoperative estimated serum levels of all described enzymes found to be significantly elevated in patients of group A (with bowel ischemia) in comparison with group B (with no bowel ischemia). Sensitivity and specificity for elevated levels of S. LDH were 88% and 68%, for SGOT 68% and 80%, for S. ALP 72% and 68%, for S. CPK-MB 76% and 84%, and for S. phosphorus 76% and 68% respectively.
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Several clinical studies found that LDH is a useful biomarker for acute mesenteric ischemia.
“Several clinical studies found that LDH is a useful biomarker for acute mesenteric ischemia, [55,56].”
From Acute mesenteric ischemia in COVID-19 patients (2021) · cites this paper as [56]
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Acute mesenteric ischemia in COVID-19 patients
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- Authors
- Soni, N., Bhutra, S., Vidyarthi, S. H., Sharma, V., & Singh, A.
- Affiliations
- Jawaharlal Nehru Medical College (IN)
- Venue
- International Surgery Journal
- Publisher
- Medip Academy
- Published
- 2017-05-24
- Volume
- 4
- Issue
- 6
- Pages
- 1997
- ISSN
- 2349-2902 (ISSN-L)
- 2349-3305
- OpenAlex
- W2620483004
- Cited by
- 4
- References
- 29
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- International Surgery Journal (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Health Sciences › Medicine › Emergency Medicine › Appendicitis Diagnosis and Management
- Keywords
- intestinal ischemia, acute abdomen, acute mesenteric ischemia, serum lactate dehydrogenase, aspartate aminotransferase, creatine kinase, alkaline phosphatase, serum phosphorus, serum biomarkers, sensitivity and specificity, bowel infarction
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