Utility of CBNAAT, Cytology and Histology in diagnosis of suspected tubercular solid lymph node
Open accessAbstract
Background : Cytology, Ziehl Neelsen staining and Mantoux test are conventionally used to test and treat lymph node tuberculosis. Cartridge Based Nucleic Acid Amplification Test (CBNAAT) is being now recommended for diagnosis of all extrapulmonary tuberculosis including tubercular lymphadenitis. Aims and Objectives : To asses efficacy of various diagnostic tools for diagnosis of lymph node tuberculosis in solid state (non-caseating stage). Material and Methods : It was a prospective study conducted by including all consecutive patients with lymph node swelling suggestive of tuberculosis. Fine needle aspirate was subjected for cytology and CBNAAT. If both turned negative, excision biopsy was performed and subjected for histology. Results were tabulated. Results : Sixty patients were included after excluding certain patients with caseous aspiration. Thirtyone (51.67%) had mycobacterium detected in CBNAAT. Remaining patients after histology had following diagnosis; Tuberculosis in eight, nonspecific reactive hyperplasia in 11, metastasis and lymphoma in four and Non Tubercular Mycobacteria and actinomycosis in one each patient. Conclusion : CBNAAT is an effective tool for diagnosing lymph node tuberculosis even in early stages of pathology. Relying solely on cytology to diagnose tuberculosis should be discouraged. Keywords: Caseation, CBNAAT, Cytology, Excision biopsy, Lymphadenopathy, Tuberculosis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GeneXpert MTB-RIF is at par with culture, which demands 100 bacilli per ml of sample.
“GeneXpert MTB-RIF is at par with culture which demands 100 bacilli per ml of sample (Manju and Madhusudhan 2020).”
From Combination method for the diagnosis of Tuberculous lymphadenitis in high burden settings (2022) · cites this paper as Manju and Madhusudhan 2020
GeneXpert MTB-RIF can detect as low bacterial load as 100-130 bacilli per ml of sample, making it ideal for paucibacillary tuberculosis.
“GeneXpert MTB-RIF can detect as low bacterial load as 100-130 bacilli per ml of sample makes it ideal for paucibacillary tuberculosis.”
From Combination method for the diagnosis of Tuberculous lymphadenitis in high burden settings (2022) · cites this paper as Manju and Madhusudhan 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Denkinger, C. M., Schumacher, S. G., Boehme, C. C., Dendukuri, N., Pai, M., & Steingart, K. R. (2014) · European Respiratory Journal · doi:10.1183/09031936.00007814 · Cited by 527 · see citing works
Evaluation of the analytical performance of the Xpert MTB/RIF assay
Blakemore, R., Story, E., Helb, D., Kop, J., Banada, P., Owens, M. R., Chakravorty, S., Jones, M., & Alland, D. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.00128-10 · Cited by 485 · see citing works
Current diagnosis and management of peripheral tuberculous lymphadenitis.
Fontanilla, J.-M., Barnes, A., & von Reyn, C. F. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir454 · Cited by 299 · cited 4× · see citing works
“Manju M D and Madhusudhan A V / IP Indian Journal of Immunology and Respiratory Medicine 2020;5(3):168–172 169”
BackgroundInfluentialChakravorty, S., Sen, M. K., & Tyagi, J. S. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.9.4357-4362.2005 · Cited by 282 · see citing works
Toman's Tuberculosis: Case Detection, Treatment and Monitoring: Questions and Answers
Frieden, T. R. (2004) · Cited by 264 · see citing works
Asano, S. (2012) · Journal of Clinical and Experimental Hematopathology · doi:10.3960/jslrt.52.1 · Cited by 169 · see citing works
Laboratory Diagnosis of Mycobacterium tuberculosis Infection and Disease in Children
Dunn, J. J., Starke, J. R., & Revell, P. A. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.03043-15 · Cited by 143 · see citing works
Pfyffer, G. E., & Wittwer, F. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.02283-12 · Cited by 113 · see citing works
Mapping the pattern and trends of extrapulmonary tuberculosis
Prakasha, S., Suresh, G., D′sa, I., Shetty, S., & Kumar, S. (2013) · Journal of Global Infectious Diseases · doi:10.4103/0974-777x.112277 · Cited by 105 · see citing works
Kent, D. C. (1967) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196712000-00016 · Cited by 99 · see citing works
FNAC in tuberculous lymphadenitis: experience from a tertiary level referral centre.
Paliwal, N., Sapna, T., Mullick, S., & Kumud, G. (2011) · PubMed · Cited by 76 · see citing works
Tuberculous lymphadenitis in childhood: The significance of anonymous mycobacteria
Jones, P., & Campbell, P. E. (1962) · British journal of surgery · doi:10.1002/bjs.18005022112 · Cited by 68 · see citing works
Aspiration cytology of malignant neoplasms associated with granulomas and granuloma-like features
Khurana, K. K., Stanley, M. W., Powers, C. N., et al. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980425)84:2 · Cited by 60 · see citing works
Yu, G., Zhong, F., Ye, B., Xu, X., Chen, D., & Shen, Y. (2019) · BioMed Research International · doi:10.1155/2019/4878240 · Cited by 52 · see citing works
Cytomorphological patterns of tubercular lymphadenitis revisited
Hemalatha, A., Shruti, P., Kumar, M., & Bhaskaran, A. (2014) · Annals of Medical and Health Sciences Research · doi:10.4103/2141-9248.133466 · Cited by 48 · see citing works
CBNAAT: A Boon for Early Diagnosis of Tuberculosis-Head and Neck
Sachdeva, K., & Shrivastava, T. (2018) · Indian Journal of Otolaryngology and Head & Neck Surgery · doi:10.1007/s12070-018-1364-x · Cited by 41 · see citing works
Extra Pulmonary Tuberculosis: A Diagnostic Dilemma
Jain, A. (2011) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-010-0104-0 · Cited by 39 · see citing works
Fantahun, M., Kebede, A., Yenew, B., Gemechu, T., Mamuye, Y., Tadesse, M., Brhane, B., Jibriel, A., Solomon, D., & Yaregal, Z. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222402 · Cited by 38 · see citing works
Mitra, S., Misra, R., & Rai, P. (2017) · Journal of Cytology · doi:10.4103/joc.joc_207_15 · Cited by 33 · see citing works
Tuberculous lymphadenopathy: Experience from the referral center of Northern India
Singh, S., & Tiwari, K. K. (2016) · Nigerian Medical Journal · doi:10.4103/0300-1652.182077 · Cited by 27 · see citing works
Pathogenesis of cervical tuberculous lymphadenitis: pathways to anatomic localization
Yew, W. W. (1995) · Tubercle and Lung Disease · doi:10.1016/s0962-8479(05)80019-x · Cited by 23 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Revised National TB Control Programme Technical and operational guidelines for Tuberculosis control in India -2016. Central TB division, Directorate general of health services, Ministry of health and family welfare. vol. 1. New Delhi, India; 2016. p. 1-5.
- Revised National TB Control Programme Technical and operational guidelines for Tuberculosis control in India -2016. Central TB division, Directorate general of health services, Ministry of health and family welfare. vol. 3. New Delhi, India: Casde finding and diagnosis strategy; 2016. p. 13-29.
- Time Nucleic Acid Amplification Technology for Rapid and Simultaneous Detection of Tuberculosis and Rifampicin Resistance: Xpert MTB/RIF Assay for the Diagnosis of Pulmonary and Extrapulmonary TB in Adults and Children: Policy update. World Heal Organ;2013:1-79.
- Chakravorty S, Sen MK, Tyagi JS. Diagnosis of Extrapulmonary Tuberculosis by Smear, Culture, and PCR Using Universal Sample Processing Technology. J Clin Microbiol. 2005;43(9):4357-62.
- Ahmad I. Non-specific reactive hyperpiasia of cervical lymph nodes: a follow-up. J Pak Med Ass. 1992;42(10):237-8.
Cited by
Sorted by citations
Combination method for the diagnosis of Tuberculous lymphadenitis in high burden settings
Shetty, D., & Vyas, D. (2022) · Surgical and Experimental Pathology · doi:10.1186/s42047-022-00111-z · Cited by 25 · see citing works
“GeneXpert MTB-RIF is at par with culture which demands 100 bacilli per ml of sample (Manju and Madhusudhan 2020).”
MethodInfluential
- Authors
- M D, M., & A V, M.
- Venue
- IP Indian Journal of Immunology and Respiratory Medicine
- Publisher
- IP Innovative Publication Pvt Ltd
- Published
- 2020-09-15
- Volume
- 5
- Issue
- 3
- Pages
- 168-172
- ISSN
- 2456-012X (ISSN-L)
- 2581-4214
- 2581-4222
- OpenAlex
- W3109094399
- Cited by
- 4
- References
- 21
- Citations by year
- 2024: 2 · 2022: 2
- FWCI
- 0.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- IP Indian Journal of Immunology and Respiratory Medicine (publishedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Surgery › Lymphadenopathy Diagnosis and Analysis
- Keywords
- tuberculous lymphadenitis, CBNAAT, nucleic acid amplification tests, fine needle aspiration cytology, excisional biopsy, histopathology, Ziehl-Neelsen staining, tuberculin skin test, reactive hyperplasia, extrapulmonary tuberculosis, diagnostic accuracy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
