Semen analysis of subfertility caused by testicular carcinoma
Open accessAbstract
Background: Infertility is a common problem in testicular cancer. Affected men often decide to undergo sperm banking before chemo/radiotherapy. The cumulative effects of therapy can considerably reduce fertility. Objective: Testicular cancers impair fertilizing ability, even before diagnosis. This study tries to verify individual traits and semen quality in patients with testicular cancer. Materials and Methods: This observational study analyzed 190 semen of patients with testicular cancer (16 to 47 yr old) referred to the sub-fertility laboratory at the St. Mary hospital for semen banking prior to treatment carcinoma. Several aspects of their semen analyses were examined. The cases were divided into four different categories: seminoma, teratoma, mixed germ cell tumors and others. Results: The results showed that 23 cases were azoospermic, and 13 of the patients who were not azoospermic, their sperm of “normal” morphology were too few to count. Among patients that could produce spermatozoa, 59.4% had a sperm concentration of < 20 × 106/ml. The mean of “motility excellent” and “sluggish” taken together in all the cases was 47.2%. More than 92% of the patients had an abnormal morphology. The morphology of sperm is the most sensitive semen parameter that is affected by testicular carcinoma. Conclusion: Abnormal spermatogenesis is seen in most patients with testicular cancer before treatment with radiation, chemotherapy, or surgery. The causes of poor semen quality in cancer patients are not well-understood, but the patients with impaired spermatogenesis should have precise examination to find out the correct diagnosis of problem and preserve the fertility before any treatment. Key words: Infertility, Testicular cancer, Semen analyses, Spermatogenesis.
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Febrile illness and testicular cancer have been shown to affect sperm morphology due to defective spermatogenesis.
“Febrile illness and testicular cancer have also been shown to affect sperm morphology due to defective spermatogenesis (70,71).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [71]
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- Authors
- Ghasemi, B., Mosadegh Mehrjardi, A., Jones, C., & Ghasemi, N.
- Affiliations
- University of Manchester (GB)
- Manchester Academic Health Science Centre (GB)
- Shahid Sadoughi University of Medical Sciences and Health Services (IR)
- Corresponding author
- Ghasemi, Nasrin
- Venue
- International Journal of Reproductive BioMedicine (IJRM)
- Publisher
- Knowledge E DMCC
- Published
- 2020-07-22
- Volume
- 18
- Issue
- 7
- Pages
- 539-550
- ISSN
- 1680-6433 (ISSN-L)
- 2476-3772
- 2476-4108
- PMC
- PMC7385918
- OpenAlex
- W3044759018
- Cited by
- 9
- References
- 23
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- International Journal of Reproductive BioMedicine (IJRM) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Surgery › Testicular diseases and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- testicular cancer, male infertility, subfertility, semen quality, sperm banking, azoospermia, sperm morphology, sperm motility, impaired spermatogenesis, seminoma, teratoma, germ cell tumors, fertility preservation
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