If Started Early in Life, Metformin Treatment Increases Life Span and Postpones Tumors in Female SHR Mice
Anisimov, Vladimir N., Berstein, Lev M., Popovich, Irina G., Zabezhinski, Mark A., Egormin, Peter A., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Margarita L. +3 more·2011·Aging
Cited by (284)
Items 201–284 of 284
- Evolution, mechanism and limits of dietary restriction induced health benefits & longevityFriedrich Reinhard Becker, Marthe Behrends, K. Lenhard Rudolph · 2023 · Redox Biology
- Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in miceYael N. Kusne, Emily L. Goldberg, Sara S. Parker, Sophie M. Hapak, Irina Y. Maskaykina, Wade M. Chew, Kirsten H. Limesand, Heddwen L. Brooks, Theodore John Price, Nader Sanai et al. · 2013 · AGE
- Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscleCory M. Dungan, Zhuyun Li, David Charles Wright, David L. Williamson · 2015 · Muscle & Nerve
- Reversing age-associated arterial dysfunction: insight from preclinical modelsVenkateswara Reddy Gogulamudi, Jinjin Cai, Lisa A. Lesniewski · 2018 · Journal of Applied Physiology
- Linking Nutrition, Maturation and Aging: From Thrifty Genes to the Spendthrift PhenotypeDavid Stipp · 2011 · Aging
- Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐AnalysisEdward R. Ivimey‐Cook, Zahida Sultanova, Alexei A. Maklakov · 2025 · Aging Cell
- Metformin Treatment in Old Rats and Effects on Mitochondrial IntegrityAllen J. Herbst, Austin N. Hoang, Chiye Kim, Judd M. Aiken, Debbie I. McKenzie, Deena S. Goldwater, Jonathan Wanagat · 2021 · Rejuvenation Research
- Metformin Indications, Dosage, Adverse Reactions, and ContraindicationsRoxana Adriana Stoica, Diana Simona Ștefan, Manfredi Rizzo, Andra‐Iulia Suceveanu, Adrian Paul Suceveanu, Cristian Serafinceanu, Anca Pantea Stoian · 2020 · IntechOpen eBooks
- Empirical verification of evolutionary theories of agingPavlo Kyryakov, Alejandra Gomez-Perez, Anastasia Glebov, Nimara Asbah, Luigi Bruno, Carolynne Meunier, Tatiana L. Iouk, Vladimir I. Titorenko · 2016 · Aging
- Repurposing Metformin in Precision Oncology: Mechanistic Insights, Biomarker-Guided Strategies, and Translational ImperativesShehla Shafi Khan, Imran Rashid Rangraze, Adil Farooq Wali, Malay Jhancy, Rasha Aziz Attia, Hesham Amin Hamdy Elshamy, Shukri Adam, Rana Aly Mohamed Elbeshbeishy · 2025 · Medicina
- Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they ageAna Gabriela Jiménez, Sahil Lalwani, William Cipolli · 2021 · GeroScience
- Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseasesSachi Matsubayashi, Saburo Ito, Jun Araya, Kazuyoshi Kuwano · 2023 · Frontiers in Endocrinology
- Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model systemMarina Ezcurra · 2018 · Biogerontology
- Energy metabolism modulation by biguanides in comparison with rotenone in rat liver and heartSabrina Heinz, Alexius Freyberger, Bettina Lawrenz, Ludwig Schladt, Gabriele Schmuck, Heidrun C. Ellinger-Ziegelbauer · 2019 · Archives of Toxicology
- Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolismLília Espada, Alexander Dakhovnik, Prerana Chaudhari, Asya Martirosyan, Laura Miek, Tetiana Poliezhaieva, Yvonne Schaub, Ashish Nair, Nadia Döring, Norman Rahnis et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Geroprotective effects of GdVO4:Eu3 + nanoparticles, metformin and calorie restriction in male rats with accelerated aging induced by overnutrition in early postnatal ontogenesisNikitchenko IuV, Vladimir Klochkov, Nataliya S. Kavok, Nina A. Karpenko, Svetlana L. Yefimova, Vladimir P. Semynozhenko, Irina V. Nikitchenko, Анатолий Иванович Божков · 2024 · Biogerontology
- Metformin use associated with lower risk of cancer in patients with diabetes mellitus type 2Jasna Kusturica, Aida Kulo, Edis Gušić, Sanita Maleskic Kapo, Maida Rakanović-Todić, Damir Šečić · 2017 · Medicinski Glasnik
- Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes in sex-dependent and sex-independent mannersYun Xia Zhu, Morgan Engmann, David Medina, Xiuqi Han, Pratyusa Das, Andrzej Bartke, Buffy Sue Ellsworth, Rong Yuan · 2024 · GeroScience
- The vivo antioxidant activity of self-made aged garlic extract on the d -galactose-induced mice and its mechanism research via gene chip analysisXiaomin Wang, Yukun Yang, Min Zhang · 2019 · RSC Advances
- Immunotherapies for Aging and Age-Related Diseases: Advances, Pitfalls, and ProspectsMuyang Yang, Su‐Ying Wu, Jiasi Zhang, Lisen Lu, Deqiang Deng, Qianfeng Xia, Jonathan F. Lovell, Xiujuan Shi, Honglin Jin · 2025 · Research
- Depression, Inflammation, and the Moderating Role of Metformin: Results From the Midlife in the United States Study and Sacramento Area Latino Study on AgingSumaiyah U. Syed, Jared Isaac Cortez, Stephanie J. Wilson · 2023 · Psychosomatic Medicine
- Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biologyChikkamagaluru Gopalakrishna Shashank, Raga Mandali, Umesh D. Wankhade · 2025 · Biology of Sex Differences
- Oxidative Stress, DNA Damage and Repair Pathways in Patients with Type 2 Diabetes MellitusJéssica Ellen Barbosa de Freitas Lima, Danilo J. Xavier, Elza Tiemi Sakamoto‐Hojo · 2019 · IntechOpen eBooks
- Obesity and DiabetesAlexandra Kautzky‐Willer, Rosa Lemmens‐Gruber · 2012 · Handbook of experimental pharmacology
- Improving Health in Later Life: How a Life Course Approach Could Improve Health and Well-Being in Old AgeCarmen Giefing, Beatrix Grubeck‐Loebenstein · 2018 · Springer eBooks
- Can we use the epigenetic bioactivity of caloric restriction and phytochemicals to promote healthy ageing?Michael S. Christodoulou, Adeline Thomas, Stéphane Poulain, Melita Vidaković, Maija K. Lahtela-Kakkonen, Daumantas Matulis, Philippe Bertrand, Eva Bártová, Christophe Blanquart, Emmanuel Mikros et al. · 2014 · MedChemComm
- Effects of chronic treatment with metformin on brain glucose hypometabolism and central insulin actions in transgenic mice with tauopathyVerónica Hurtado-Carneiro, Yannick Le Baut Ayuso, Esther Velázquez, Cinthya Flores Lamas, Rubén Fernández de la Rosa, Francisca Gómez-Oliver, Luis García García, Juan Miguel Ruiz‐Albusac, Miguel A. Pozo, Enrique Blázquez Fernández · 2024 · Heliyon
- Early Life Interventions: Impact on Aging and LongevityRong Yuan, Aida Adlimoghaddam, Yun Xia Zhu, Xiuqi Han, Andrzej Bartke · 2024 · Aging and Disease
- Metformin Use Among Individuals at Risk for Type 2 DiabetesLewis H. Kuller · 2012 · Current Diabetes Reports
- Comparative Analysis of Experimental Data on the Effects of Different Polyphenols on Lifespan and AgingАндрей Владимирович Панченко, Маргарита Леонидовна Тындык, Елена Ивановна Федорос, Майдин Михаил Александрович, А. Л. Семенов, Губарева Екатерина Александровна, Alexey G. Golubev, Vladimir Nikolaevich Anisimov · 2019 · Advances in Gerontology
- Multifaceted aging and rapamycinVladimir Nikolaevich Anisimov · 2013 · Aging
- From molecular damage to regulatory constraint: epigenetic and metabolic limits of cellular plasticity in agingAntoni Godlewski, Tomasz Dziaman · 2026 · Frontiers in Aging
- Metformin — today’s panacea?Magdalena Potempa, Paweł Jończyk, Kinga Szczerba, Beata Kandefer, Dariusz Kajdaniuk · 2016 · Clinical Diabetology
- In the land of not-unhappiness: On the state-of-the-art of targeting aging and age-related diseases by biomedical researchEirini Klinaki, Mikolaj B. Ogrodnik · 2024 · Mechanisms of Ageing and Development
- Dietary state and impact of DMSO on Caenorhabditis elegans aging: Insights from healthspan analysisYutaro Fukushima, Asuka Kagami, Hirotaka Sonoda, Kotomi Shimokawa, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto · 2024 · Biochemical and Biophysical Research Communications
- Stem Cell AgingPrimož J. Rožman, Katerina Jazbec, Mojca Jež · 2018 · InTech eBooks
- An Update on the Molecular Pillars of AgingLizbeth García‐Velázquez, Clorinda Arias · 2020 · Springer eBooks
- Are 50 years enough to prove the brilliant Dilman’s idea?Vladimir Nikolaevich Anisimov · 2021 · Oncotarget
- Metformin improves age-related visual cortex dysfunction in mice by reducing noise correlation in the primary visual cortexXiaoming Liu, Yifeng Zhou, Jiachen Liu, Guangwei Xu · 2025 · Frontiers in Aging Neuroscience
- Age-related obesity and inflammaging in catsMiki Kobayashi, Motoo Kobayashi · 2025 · Frontiers in Veterinary Science
- THE STUDY OF LONGEVITY: RECENT UPDATES AND FURTHER DIRECTION. PART 2Yu. V. Kotovskaya, О. N. Tkacheva, Н. К. Рунихина, Daria A. Kashtanova, Sergey Anatol'evich Boytsov · 2017 · CARDIOVASCULAR THERAPY AND PREVENTION
- MetforminJared M. Campbell · 2023 · Elsevier eBooks
- Exploring the Potential to Extend Productive Lifespan in Nondiabetics through Maintaining Optimal Insulin Sensitivity: Amelioration of an Abated Version of the Metabolic SyndromeHarry G. Preuss, Gilbert R. Kaats, Nate Mrvichin, Okezie I. Aruoma, Debasis Bagchi, Rich Scheckenbach · 2024 · Global Journal of Medical Pharmaceutical and Biomedical Update
- Metformin: od mehanizmov delovanja do napredne klinične uporabeMiodrag Janić, Špela Volčanšek, Mojca Lunder, Andrej Janež · 2017 · Slovenian Medical Journal
- Metformin Modulates the Mechanisms of AgeingAdriana Florinela Cătoi, Andra Diana Andreicuț, Dan Cristian Vodnar, Katalin Szabó, Andreea Corina, Andreea Letiția Arsene, Simona Ștefan, Roxana Adriana Stoica, Manfredi Rizzo · 2019 · IntechOpen eBooks
- Mechanisms of cell senescence in agingThomas von Zglinicki · 2021 · Elsevier eBooks
- Repurposing of Drugs in AgingDhivya P. Sundaram, Hemamalini Vedagiri, Gowtham Kumar Subbaraj, Kumpati Premkumar · 2024 · Springer eBooks
- Exploring the Role of Senescent Cells in Neurodegenerative Pathology: A Window Into Promising Therapeutic AvenuesGabriela Bentolila, Niharika Agrawal, Julie Phung, Linh M. Van, Gatik Trivedi · 2024 · Berkeley Pharma Tech Journal of Medicine
- Aging and ApoptosisDavid P. Clark, Nanette J. Pazdernik · 2015 · Elsevier eBooks
- Anti-Aging DrugsAlexander M. Vaiserman · 2016 · Elsevier eBooks
- Physical frailtyYiming Pan, Lina Ma · 2022 · Elsevier eBooks
- The effect of metformin on absolute telomere lengthCameron Robb-Mackay · 2018
- Estudo do estresse oxidativo e influência da hiperglicemia crônica nos perfis de expressão gênica em pacientes com diabetes mellitus tipo 2Jéssica Ellen Barbosa de Freitas Lima · 2019
- Mechanisms under Metformin and Rapamycin as Anti-aging DrugsQian Feng, Bangwei Chen, Chuyao Wang, Chao Nie, Tao Li · 2020
- The role of insulin and IGF2 signalling on metabolic pathways in prostate cancer progressionAmy Anne Lubik · 2011 · Faculty of Science and Technology; Institute of Health and Biomedical Innovation
- Mediators and markers of mammalian lifespan extension: Proteomic, proliferative and hormonal adaptations in mouse models of extended lifespanAirlia C. S. Thompson · 2014 · ProQuest Demo Repository
- The Way Forward: TranslationJames L. Kirkland, Tamar Tchkonia · 2015 · Springer eBooks
- Conference on 'Nutrition and healthy ageing' Symposium 3: Nutritional modulation of the ageing trajectoryColin Selman · 2014
- The Impact of Rapamycin and Metformin on Genome Organization and Function in Normal Human FibroblastsZoe E. Gillespie · 2016 · University Library - University of Saskatchewan (University of Saskatchewan)
- The Dissection of Signaling Cascades in Neural Stem Cell Proliferation & GBM PromotionYael N. Kusne · 2014
- Natural Genetic Variation Underlying UVR Sensitivity in Drosophila melanogasterKamaldeep Chana · 2015 · Leicester Research Archive (University of Leicester)
- Effects of AMP-activated kinase modulators on intracellular Ca2+ signalling and C. elegans lifespanJessica Arias-del-Val · 2018
- Gender Specificity of the Effect of Neonatal Melatonin Administration on Lifespan and Age-Associated Pathology in 129/Sv MiceM. N. Yurova, Маргарита Леонидовна Тындык, Irina G. Popovich, Alexey G. Golubev, Vladimir Nikolaevich Anisimov · 2019 · Advances in Gerontology
- Fasten und LanglebigkeitBernd Kleine-Gunk · 2021 · Ernährung & Medizin
- Faculty Opinions recommendation of The hallmarks of aging.Ian David Hickson, Hocine W Mankouri · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- An overview of recent advancements in anti-aging medicinesMuhammad Arsalan Ali Sajid, Muhammad Umair Hassan, Ayesha Ayesha · 2022 · World Journal of Advanced Research and Reviews
- Faculty Opinions recommendation of Metformin improves healthspan and lifespan in mice.William Henry Colledge · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- MetforminJared M. Campbell · 2018 · Elsevier eBooks
- Disrupted cellular quality control mechanisms in agingCristina Carvalho, Joana F. Pires, Paula Isabel Moreira, Nuno Raimundo · 2022 · Elsevier eBooks
- Cellular senescence during agingThomas von Zglinicki · 2022 · Elsevier eBooks
- Interventions that target fundamental aging mechanisms: myths and realitiesErin O. Wissler Gerdes, Yi Zhun Zhu, Tamar Tchkonia, James L. Kirkland · 2022 · Elsevier eBooks
- Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosisTakashi Kaito, Yuichiro Ukon, Hiromasa Hirai, Takayuki Kitahara, Masayuki Bun, Joe Kodama, Daisuke Tateiwa, Shinichi Nakagawa, Masato Ikuta, Takuya Furuichi et al. · 2023 · Research Square
- Anti-aging DrugsGlenda Elaine Bilder, Patricia Brown-O’Hara · 2025 · Springer eBooks
- A Review on the Association Between Metformin Use and Different Types of AnemiaMorteza Garmei, Fatemeh Shams · 2025 · SN Comprehensive Clinical Medicine
- Metabolic health and intermittent fasting: implications for age-related disordersShampa Ghosh, Dr. Krishna Kumar Singh, Manchala Raghunath, Jitendra Kumar Sinha · 2025 · Elsevier eBooks
- Cellular autophagy and aging: role in intermittent fasting-induced health benefitsVivek Singh, Mohammad Kashif, Tanvi Singh, Roma Pahwa, Abhishek Kumar Singh, Anand Singh · 2025 · Elsevier eBooks
- Natural variations in yeast aging reveal genetic and environmental factorsBenjamin P. Barré · 2018
- Rôle et régulation de l'haptoglobine adipocytaire au cours du vieillissementGwendoline Astre · 2018 · theses.fr (ABES)
- Caractérisation fonctionnelle de jouvence, un petit ARN nucléolaire requis dans l’épithélium de l’intestin chez la drosophileStéphanie Soulé · 2020 · theses.fr (ABES)
- REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effectDaisy V. Wilson, Animesh Acharjee, Niharika Arora Duggal, Jose R. Hombrebueno, Simon W. Jones, Jonathan W. Lewis, João Pedro de Magalhães, Yessica Martínez-Serrato, Ali Mazaheri, Helen M. McGettrick et al. · 2026 · PLoS ONE
- Yaşlanma Kader mi? Yaşlanma Biyolojisi ve GenetiğiH. Ümit Lüleyap · 2026 · Akademisyen Kitabevi eBooks
- Metformin at the convergence of aging and longevityJarra Manneh, May Alasmar, Nady El Hajj · 2026 · Aging
- The Role of Physical Activity and Diet in Regulating Aging: From Universal Mechanisms to Personalized Longevity StrategiesEmiliya S. Egorova, Ildus I. Ahmetov · 2026 · Advances in Gerontology
- Isolation and characterization of human endothelial colony forming cells (ECFCs) and effect of oxidative stress on their differentiationMohsin Wahid · 2014