If Started Early in Life, Metformin Treatment Increases Life Span and Postpones Tumors in Female SHR Mice

Anisimov, Vladimir N., Berstein, Lev M., Popovich, Irina G., Zabezhinski, Mark A., Egormin, Peter A., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Margarita L. +3 more·2011·Aging

Cited by (284)

Items 201–284 of 284

  1. Evolution, mechanism and limits of dietary restriction induced health benefits & longevity
    Friedrich Reinhard Becker, Marthe Behrends, K. Lenhard Rudolph · 2023 · Redox Biology
  2. Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice
    Yael N. Kusne, Emily L. Goldberg, Sara S. Parker, Sophie M. Hapak, Irina Y. Maskaykina, Wade M. Chew, Kirsten H. Limesand, Heddwen L. Brooks, Theodore John Price, Nader Sanai et al. · 2013 · AGE
  3. Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle
    Cory M. Dungan, Zhuyun Li, David Charles Wright, David L. Williamson · 2015 · Muscle & Nerve
  4. Reversing age-associated arterial dysfunction: insight from preclinical models
    Venkateswara Reddy Gogulamudi, Jinjin Cai, Lisa A. Lesniewski · 2018 · Journal of Applied Physiology
  5. Linking Nutrition, Maturation and Aging: From Thrifty Genes to the Spendthrift Phenotype
    David Stipp · 2011 · Aging
  6. Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis
    Edward R. Ivimey‐Cook, Zahida Sultanova, Alexei A. Maklakov · 2025 · Aging Cell
  7. Metformin Treatment in Old Rats and Effects on Mitochondrial Integrity
    Allen J. Herbst, Austin N. Hoang, Chiye Kim, Judd M. Aiken, Debbie I. McKenzie, Deena S. Goldwater, Jonathan Wanagat · 2021 · Rejuvenation Research
  8. Metformin Indications, Dosage, Adverse Reactions, and Contraindications
    Roxana Adriana Stoica, Diana Simona Ștefan, Manfredi Rizzo, Andra‐Iulia Suceveanu, Adrian Paul Suceveanu, Cristian Serafinceanu, Anca Pantea Stoian · 2020 · IntechOpen eBooks
  9. Empirical verification of evolutionary theories of aging
    Pavlo Kyryakov, Alejandra Gomez-Perez, Anastasia Glebov, Nimara Asbah, Luigi Bruno, Carolynne Meunier, Tatiana L. Iouk, Vladimir I. Titorenko · 2016 · Aging
  10. Repurposing Metformin in Precision Oncology: Mechanistic Insights, Biomarker-Guided Strategies, and Translational Imperatives
    Shehla Shafi Khan, Imran Rashid Rangraze, Adil Farooq Wali, Malay Jhancy, Rasha Aziz Attia, Hesham Amin Hamdy Elshamy, Shukri Adam, Rana Aly Mohamed Elbeshbeishy · 2025 · Medicina
  11. Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age
    Ana Gabriela Jiménez, Sahil Lalwani, William Cipolli · 2021 · GeroScience
  12. Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases
    Sachi Matsubayashi, Saburo Ito, Jun Araya, Kazuyoshi Kuwano · 2023 · Frontiers in Endocrinology
  13. Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model system
    Marina Ezcurra · 2018 · Biogerontology
  14. Energy metabolism modulation by biguanides in comparison with rotenone in rat liver and heart
    Sabrina Heinz, Alexius Freyberger, Bettina Lawrenz, Ludwig Schladt, Gabriele Schmuck, Heidrun C. Ellinger-Ziegelbauer · 2019 · Archives of Toxicology
  15. Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism
    Lília Espada, Alexander Dakhovnik, Prerana Chaudhari, Asya Martirosyan, Laura Miek, Tetiana Poliezhaieva, Yvonne Schaub, Ashish Nair, Nadia Döring, Norman Rahnis et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Geroprotective effects of GdVO4:Eu3 + nanoparticles, metformin and calorie restriction in male rats with accelerated aging induced by overnutrition in early postnatal ontogenesis
    Nikitchenko IuV, Vladimir Klochkov, Nataliya S. Kavok, Nina A. Karpenko, Svetlana L. Yefimova, Vladimir P. Semynozhenko, Irina V. Nikitchenko, Анатолий Иванович Божков · 2024 · Biogerontology
  17. Metformin use associated with lower risk of cancer in patients with diabetes mellitus type 2
    Jasna Kusturica, Aida Kulo, Edis Gušić, Sanita Maleskic Kapo, Maida Rakanović-Todić, Damir Šečić · 2017 · Medicinski Glasnik
  18. Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes in sex-dependent and sex-independent manners
    Yun Xia Zhu, Morgan Engmann, David Medina, Xiuqi Han, Pratyusa Das, Andrzej Bartke, Buffy Sue Ellsworth, Rong Yuan · 2024 · GeroScience
  19. The vivo antioxidant activity of self-made aged garlic extract on the d -galactose-induced mice and its mechanism research via gene chip analysis
    Xiaomin Wang, Yukun Yang, Min Zhang · 2019 · RSC Advances
  20. Immunotherapies for Aging and Age-Related Diseases: Advances, Pitfalls, and Prospects
    Muyang Yang, Su‐Ying Wu, Jiasi Zhang, Lisen Lu, Deqiang Deng, Qianfeng Xia, Jonathan F. Lovell, Xiujuan Shi, Honglin Jin · 2025 · Research
  21. Depression, Inflammation, and the Moderating Role of Metformin: Results From the Midlife in the United States Study and Sacramento Area Latino Study on Aging
    Sumaiyah U. Syed, Jared Isaac Cortez, Stephanie J. Wilson · 2023 · Psychosomatic Medicine
  22. Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology
    Chikkamagaluru Gopalakrishna Shashank, Raga Mandali, Umesh D. Wankhade · 2025 · Biology of Sex Differences
  23. Oxidative Stress, DNA Damage and Repair Pathways in Patients with Type 2 Diabetes Mellitus
    Jéssica Ellen Barbosa de Freitas Lima, Danilo J. Xavier, Elza Tiemi Sakamoto‐Hojo · 2019 · IntechOpen eBooks
  24. Obesity and Diabetes
    Alexandra Kautzky‐Willer, Rosa Lemmens‐Gruber · 2012 · Handbook of experimental pharmacology
  25. Improving Health in Later Life: How a Life Course Approach Could Improve Health and Well-Being in Old Age
    Carmen Giefing, Beatrix Grubeck‐Loebenstein · 2018 · Springer eBooks
  26. Can we use the epigenetic bioactivity of caloric restriction and phytochemicals to promote healthy ageing?
    Michael S. Christodoulou, Adeline Thomas, Stéphane Poulain, Melita Vidaković, Maija K. Lahtela-Kakkonen, Daumantas Matulis, Philippe Bertrand, Eva Bártová, Christophe Blanquart, Emmanuel Mikros et al. · 2014 · MedChemComm
  27. Effects of chronic treatment with metformin on brain glucose hypometabolism and central insulin actions in transgenic mice with tauopathy
    Verónica Hurtado-Carneiro, Yannick Le Baut Ayuso, Esther Velázquez, Cinthya Flores Lamas, Rubén Fernández de la Rosa, Francisca Gómez-Oliver, Luis García García, Juan Miguel Ruiz‐Albusac, Miguel A. Pozo, Enrique Blázquez Fernández · 2024 · Heliyon
  28. Early Life Interventions: Impact on Aging and Longevity
    Rong Yuan, Aida Adlimoghaddam, Yun Xia Zhu, Xiuqi Han, Andrzej Bartke · 2024 · Aging and Disease
  29. Metformin Use Among Individuals at Risk for Type 2 Diabetes
    Lewis H. Kuller · 2012 · Current Diabetes Reports
  30. Comparative Analysis of Experimental Data on the Effects of Different Polyphenols on Lifespan and Aging
    Андрей Владимирович Панченко, Маргарита Леонидовна Тындык, Елена Ивановна Федорос, Майдин Михаил Александрович, А. Л. Семенов, Губарева Екатерина Александровна, Alexey G. Golubev, Vladimir Nikolaevich Anisimov · 2019 · Advances in Gerontology
  31. Multifaceted aging and rapamycin
    Vladimir Nikolaevich Anisimov · 2013 · Aging
  32. From molecular damage to regulatory constraint: epigenetic and metabolic limits of cellular plasticity in aging
    Antoni Godlewski, Tomasz Dziaman · 2026 · Frontiers in Aging
  33. Metformin — today’s panacea?
    Magdalena Potempa, Paweł Jończyk, Kinga Szczerba, Beata Kandefer, Dariusz Kajdaniuk · 2016 · Clinical Diabetology
  34. In the land of not-unhappiness: On the state-of-the-art of targeting aging and age-related diseases by biomedical research
    Eirini Klinaki, Mikolaj B. Ogrodnik · 2024 · Mechanisms of Ageing and Development
  35. Dietary state and impact of DMSO on Caenorhabditis elegans aging: Insights from healthspan analysis
    Yutaro Fukushima, Asuka Kagami, Hirotaka Sonoda, Kotomi Shimokawa, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto · 2024 · Biochemical and Biophysical Research Communications
  36. Stem Cell Aging
    Primož J. Rožman, Katerina Jazbec, Mojca Jež · 2018 · InTech eBooks
  37. An Update on the Molecular Pillars of Aging
    Lizbeth García‐Velázquez, Clorinda Arias · 2020 · Springer eBooks
  38. Are 50 years enough to prove the brilliant Dilman’s idea?
    Vladimir Nikolaevich Anisimov · 2021 · Oncotarget
  39. Metformin improves age-related visual cortex dysfunction in mice by reducing noise correlation in the primary visual cortex
    Xiaoming Liu, Yifeng Zhou, Jiachen Liu, Guangwei Xu · 2025 · Frontiers in Aging Neuroscience
  40. Age-related obesity and inflammaging in cats
    Miki Kobayashi, Motoo Kobayashi · 2025 · Frontiers in Veterinary Science
  41. THE STUDY OF LONGEVITY: RECENT UPDATES AND FURTHER DIRECTION. PART 2
    Yu. V. Kotovskaya, О. N. Tkacheva, Н. К. Рунихина, Daria A. Kashtanova, Sergey Anatol'evich Boytsov · 2017 · CARDIOVASCULAR THERAPY AND PREVENTION
  42. Metformin
    Jared M. Campbell · 2023 · Elsevier eBooks
  43. Exploring the Potential to Extend Productive Lifespan in Nondiabetics through Maintaining Optimal Insulin Sensitivity: Amelioration of an Abated Version of the Metabolic Syndrome
    Harry G. Preuss, Gilbert R. Kaats, Nate Mrvichin, Okezie I. Aruoma, Debasis Bagchi, Rich Scheckenbach · 2024 · Global Journal of Medical Pharmaceutical and Biomedical Update
  44. Metformin: od mehanizmov delovanja do napredne klinične uporabe
    Miodrag Janić, Špela Volčanšek, Mojca Lunder, Andrej Janež · 2017 · Slovenian Medical Journal
  45. Metformin Modulates the Mechanisms of Ageing
    Adriana Florinela Cătoi, Andra Diana Andreicuț, Dan Cristian Vodnar, Katalin Szabó, Andreea Corina, Andreea Letiția Arsene, Simona Ștefan, Roxana Adriana Stoica, Manfredi Rizzo · 2019 · IntechOpen eBooks
  46. Mechanisms of cell senescence in aging
    Thomas von Zglinicki · 2021 · Elsevier eBooks
  47. Repurposing of Drugs in Aging
    Dhivya P. Sundaram, Hemamalini Vedagiri, Gowtham Kumar Subbaraj, Kumpati Premkumar · 2024 · Springer eBooks
  48. Exploring the Role of Senescent Cells in Neurodegenerative Pathology: A Window Into Promising Therapeutic Avenues
    Gabriela Bentolila, Niharika Agrawal, Julie Phung, Linh M. Van, Gatik Trivedi · 2024 · Berkeley Pharma Tech Journal of Medicine
  49. Aging and Apoptosis
    David P. Clark, Nanette J. Pazdernik · 2015 · Elsevier eBooks
  50. Anti-Aging Drugs
    Alexander M. Vaiserman · 2016 · Elsevier eBooks
  51. Physical frailty
    Yiming Pan, Lina Ma · 2022 · Elsevier eBooks
  52. The effect of metformin on absolute telomere length
    Cameron Robb-Mackay · 2018
  53. Estudo do estresse oxidativo e influência da hiperglicemia crônica nos perfis de expressão gênica em pacientes com diabetes mellitus tipo 2
    Jéssica Ellen Barbosa de Freitas Lima · 2019
  54. Mechanisms under Metformin and Rapamycin as Anti-aging Drugs
    Qian Feng, Bangwei Chen, Chuyao Wang, Chao Nie, Tao Li · 2020
  55. The role of insulin and IGF2 signalling on metabolic pathways in prostate cancer progression
    Amy Anne Lubik · 2011 · Faculty of Science and Technology; Institute of Health and Biomedical Innovation
  56. Mediators and markers of mammalian lifespan extension: Proteomic, proliferative and hormonal adaptations in mouse models of extended lifespan
    Airlia C. S. Thompson · 2014 · ProQuest Demo Repository
  57. The Way Forward: Translation
    James L. Kirkland, Tamar Tchkonia · 2015 · Springer eBooks
  58. Conference on 'Nutrition and healthy ageing' Symposium 3: Nutritional modulation of the ageing trajectory
    Colin Selman · 2014
  59. The Impact of Rapamycin and Metformin on Genome Organization and Function in Normal Human Fibroblasts
    Zoe E. Gillespie · 2016 · University Library - University of Saskatchewan (University of Saskatchewan)
  60. The Dissection of Signaling Cascades in Neural Stem Cell Proliferation & GBM Promotion
    Yael N. Kusne · 2014
  61. Natural Genetic Variation Underlying UVR Sensitivity in Drosophila melanogaster
    Kamaldeep Chana · 2015 · Leicester Research Archive (University of Leicester)
  62. Effects of AMP-activated kinase modulators on intracellular Ca2+ signalling and C. elegans lifespan
    Jessica Arias-del-Val · 2018
  63. Gender Specificity of the Effect of Neonatal Melatonin Administration on Lifespan and Age-Associated Pathology in 129/Sv Mice
    M. N. Yurova, Маргарита Леонидовна Тындык, Irina G. Popovich, Alexey G. Golubev, Vladimir Nikolaevich Anisimov · 2019 · Advances in Gerontology
  64. Fasten und Langlebigkeit
    Bernd Kleine-Gunk · 2021 · Ernährung & Medizin
  65. Faculty Opinions recommendation of The hallmarks of aging.
    Ian David Hickson, Hocine W Mankouri · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  66. An overview of recent advancements in anti-aging medicines
    Muhammad Arsalan Ali Sajid, Muhammad Umair Hassan, Ayesha Ayesha · 2022 · World Journal of Advanced Research and Reviews
  67. Faculty Opinions recommendation of Metformin improves healthspan and lifespan in mice.
    William Henry Colledge · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  68. Metformin
    Jared M. Campbell · 2018 · Elsevier eBooks
  69. Disrupted cellular quality control mechanisms in aging
    Cristina Carvalho, Joana F. Pires, Paula Isabel Moreira, Nuno Raimundo · 2022 · Elsevier eBooks
  70. Cellular senescence during aging
    Thomas von Zglinicki · 2022 · Elsevier eBooks
  71. Interventions that target fundamental aging mechanisms: myths and realities
    Erin O. Wissler Gerdes, Yi Zhun Zhu, Tamar Tchkonia, James L. Kirkland · 2022 · Elsevier eBooks
  72. Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis
    Takashi Kaito, Yuichiro Ukon, Hiromasa Hirai, Takayuki Kitahara, Masayuki Bun, Joe Kodama, Daisuke Tateiwa, Shinichi Nakagawa, Masato Ikuta, Takuya Furuichi et al. · 2023 · Research Square
  73. Anti-aging Drugs
    Glenda Elaine Bilder, Patricia Brown-O’Hara · 2025 · Springer eBooks
  74. A Review on the Association Between Metformin Use and Different Types of Anemia
    Morteza Garmei, Fatemeh Shams · 2025 · SN Comprehensive Clinical Medicine
  75. Metabolic health and intermittent fasting: implications for age-related disorders
    Shampa Ghosh, Dr. Krishna Kumar Singh, Manchala Raghunath, Jitendra Kumar Sinha · 2025 · Elsevier eBooks
  76. Cellular autophagy and aging: role in intermittent fasting-induced health benefits
    Vivek Singh, Mohammad Kashif, Tanvi Singh, Roma Pahwa, Abhishek Kumar Singh, Anand Singh · 2025 · Elsevier eBooks
  77. Natural variations in yeast aging reveal genetic and environmental factors
    Benjamin P. Barré · 2018
  78. Rôle et régulation de l'haptoglobine adipocytaire au cours du vieillissement
    Gwendoline Astre · 2018 · theses.fr (ABES)
  79. Caractérisation fonctionnelle de jouvence, un petit ARN nucléolaire requis dans l’épithélium de l’intestin chez la drosophile
    Stéphanie Soulé · 2020 · theses.fr (ABES)
  80. REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect
    Daisy V. Wilson, Animesh Acharjee, Niharika Arora Duggal, Jose R. Hombrebueno, Simon W. Jones, Jonathan W. Lewis, João Pedro de Magalhães, Yessica Martínez-Serrato, Ali Mazaheri, Helen M. McGettrick et al. · 2026 · PLoS ONE
  81. Yaşlanma Kader mi? Yaşlanma Biyolojisi ve Genetiği
    H. Ümit Lüleyap · 2026 · Akademisyen Kitabevi eBooks
  82. Metformin at the convergence of aging and longevity
    Jarra Manneh, May Alasmar, Nady El Hajj · 2026 · Aging
  83. The Role of Physical Activity and Diet in Regulating Aging: From Universal Mechanisms to Personalized Longevity Strategies
    Emiliya S. Egorova, Ildus I. Ahmetov · 2026 · Advances in Gerontology
  84. Isolation and characterization of human endothelial colony forming cells (ECFCs) and effect of oxidative stress on their differentiation
    Mohsin Wahid · 2014