If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

Cited by (284)

Items 101–200 of 284

  1. Gerosuppressant Metformin: less is more
    Javier Abel Menéndez, Sílvia Cufí, Cristina Oliveras‐Ferraros, Luciano Vellón, Jorge Joven, Alejandro Vázquez‐Martín · 2011 · Aging
  2. Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan
    Michelle T. Burstein, Pavlo Kyryakov, Adam Beach, Vincent R. Richard, Olivia Koupaki, Alejandra Gomez-Perez, Anna Leonov, Sean Levy, Forough Noohi, Vladimir I. Titorenko · 2012 · Cell Cycle
  3. Stem Cell Senescence and Regenerative Paradigms
    Antonio Paolo Beltrami, Daniela Cesselli, Carlo Alberto Beltrami · 2011 · Clinical Pharmacology & Therapeutics
  4. Disease or not, aging is easily treatable
    Mikhail V. Blagosklonny · 2018 · Aging
  5. Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span
    Sofiya Milman, Nir Barzilai · 2015 · Cold Spring Harbor Perspectives in Medicine
  6. The Mitochondria-Targeted Antioxidant SkQ1 but Not N-Acetylcysteine Reverses Aging-Related Biomarkers in Rats
    Kolosova, Nataliya G., Stefanova, Natalia A., Muraleva, Natalia A., Skulachev, Vladimir P. · 2012 · Aging
  7. Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
    Olga V. Leontieva, Geraldine Paszkiewicz, Mikhail V. Blagosklonny · 2012 · Aging
  8. Immunosuppressants in cancer prevention and therapy
    Mikhail V. Blagosklonny · 2013 · OncoImmunology
  9. Metformin, aging and cancer
    Olga V. Moiseeva, Xavier Deschênes‐Simard, Michaël Pollak, Gerardo Ferbeyre · 2013 · Aging
  10. Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions
    Weiyi Shen, Jiamin He, Tongyao Hou, Jianmin Si, Shujie Chen · 2022 · Aging and Disease
  11. Evaluation for clinical benefit of metformin in patients with idiopathic pulmonary fibrosis and type 2 diabetes mellitus: a national claims-based cohort analysis
    Taylor Teague, Stephanie R. Payne, Bryan T. Kelly, Timothy M. Dempsey, Rozalina G. McCoy, Lindsey R. Sangaralingham, ANDREW HAR LIMPER · 2022 · Respiratory Research
  12. The effect of metformin on cognitive function: A systematic review and meta-analysis
    Ozra Tabatabaei‐Malazy, Fatemeh Bandarian, Mostafa Qorbani, Shahrzad Mohseni, Somayeh Mirsadeghi, Maryam Peimani, Bagher A. Larijani · 2022 · Journal of Psychopharmacology
  13. Selective anti-cancer agents as anti-aging drugs
    Mikhail V. Blagosklonny · 2013 · Cancer Biology & Therapy
  14. Dietary restriction and the pursuit of effective mimetics
    Colin Selman · 2014 · Proceedings of The Nutrition Society
  15. Effect of Metformin on Viability, Morphology, and Ultrastructure of Mouse Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells and Balb/3T3 Embryonic Fibroblast Cell Line
    Agnieszka Śmieszek, Aleksandra Anna Czyrek, Katarzyna Basińska, Justyna Trynda, Aneta Skaradzińska, Anna Siudzińska, Monika Marędziak, Krzysztof Marycz · 2015 · BioMed Research International
  16. Anti-Diabetic Effects of Ethanol Extract from Sanghuangporous vaninii in High-Fat/Sucrose Diet and Streptozotocin-Induced Diabetic Mice by Modulating Gut Microbiota
    Zirui Huang, Liyuan Zhao, Fu-Rong Zhu, Yun Liu, Jian-Yong Xiao, Zhichao Chen, Xu‐Cong Lv, Ying Huang, Bin Liu · 2022 · Foods
  17. AMPK as a Pro-longevity Target
    Kristopher Burkewitz, Heather J. M. Weir, William B. Mair · 2016 · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions
  18. Metformin and cognition from the perspectives of sex, age, and disease
    Kiran Chaudhari, Conner D. Reynolds, Shao-Hua Yang · 2020 · GeroScience
  19. Lifespan Modulation in Mice and the Confounding Effects of Genetic Background
    Lorna Mulvey, Amy Sinclair, Colin Selman · 2014 · Journal of genetics and genomics/Journal of Genetics and Genomics
  20. Diet Modification and Metformin Have a Beneficial Effect in a Fly Model of Obesity and Mucormycosis
    Fazal Shirazi, Dimitrios Farmakiotis, Yuanqing Yan, Nathaniel D. Albert, Kim-Anh Do, Dimitrios P. Kontoyiannis · 2014 · PLoS ONE
  21. Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions
    Mikhail V. Blagosklonny · 2012 · Oncotarget
  22. Potential Anti-Aging Substances Derived from Seaweeds
    Lei Cao, Sang Gil Lee, Kwon Taek Lim, Hyeung‐Rak Kim · 2020 · Marine Drugs
  23. In search of antiaging modalities: Evaluation of mTOR‐ and ROS/DNA damage‐signaling by cytometry
    Zbigniew Darżynkiewicz, Hong Zhao, H. Dorota Halicka, Jiangwei Li, Yong‐Syu Lee, Tze‐chen Hsieh, JOSEPH M. WU · 2014 · Cytometry Part A
  24. Taming expectations of metformin as a treatment to extend healthspan
    Adam R. Konopka, Benjamin F. Miller · 2019 · GeroScience
  25. Metformin monotherapy downregulates diabetes-associated inflammatory status and impacts on mortality
    Tizazu, Anteneh Mehari, Nyunt, Ma Shwe Zin, Cexus, Olivier, Suku, Koolarina, Mok, Esther, Xian, Chin Hui, Chong, Joni, Tan, Crystal, How, Wilson, Hubert, Sandra et al. · 2019 · Frontiers in Physiology
  26. Metformin As a Geroprotector
    Sven Bulterijs · 2011 · Rejuvenation Research
  27. Targeting ageing and preventing organ degeneration with metformin
    Anthony Paulo Sunjaya, Angela Felicia Sunjaya · 2020 · Diabetes & Metabolism
  28. STOP accelerating lung aging for the treatment of COPD
    Kazuhiro Ito, Nicolas Mercado · 2014 · Experimental Gerontology
  29. Metabolaging: a new geroscience perspective linking aging pathologies and metabolic dysfunction
    Fadi Khalaf, Dalia Barayan, Sean Saldanha, Marc G. Jeschke · 2025 · Metabolism
  30. Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast
    Kyung-Mi Choi, Hye-Lan Lee, Young-Yon Kwon, Mi-Sun Kang, Sung-Keun Lee, Cheol‐Koo Lee · 2013 · Biochemical and Biophysical Research Communications
  31. Metformin: A Rising Star to Fight the Epithelial Mesenchymal Transition in Oncology
    Guislaine Barrière, Michel Tartary, Michel Rigaud · 2013 · Anti-Cancer Agents in Medicinal Chemistry
  32. The Function of Metformin in Aging-Related Musculoskeletal Disorders
    Yanhong Song, Ziyi Wu, Ping Zhao · 2022 · Frontiers in Pharmacology
  33. Mechanisms of ageing: growth hormone, dietary restriction, and metformin
    Jansher Khan, Ida Pernicova, Kiran Nisar, Márta Korbonits · 2023 · The Lancet Diabetes & Endocrinology
  34. Age‐related AMP‐activated protein kinase alterations: From cellular energetics to longevity
    Моргунова Галина Васильевна, А. А. Клебанов · 2019 · Cell Biochemistry and Function
  35. Fibroblast Growth Factor-21 Is a Promising Dietary Restriction Mimetic
    Andrew R. Mendelsohn, James W. Larrick · 2012 · Rejuvenation Research
  36. Dysregulation of the mTOR pathway in p53-deficient mice
    Olga V. Leontieva, Liliya R. Novototskaya, Geraldine Paszkiewicz, Elena A Komarova, Andrei V. Gudkov, Mikhail V. Blagosklonny · 2013 · Cancer Biology & Therapy
  37. Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female Mice
    Xudong Zhu, Weiyan Shen, Zhu Liu, Shihao Sheng, Wei Xiong, Ruikun He, Xuguang Zhang, Likun Ma, Zhenyu Ju · 2021 · Frontiers in Cell and Developmental Biology
  38. AMPK activation—protean potential for boosting healthspan
    Mark Frederick McCarty · 2013 · AGE
  39. Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective
    Wheeler Torres, Manuel Nava, Néstor Galbán, Yosselin Gómez, Valery Morillo, Milagros Rojas, Clímaco Cano, Maricarmen Chacín, Luis D’Marco, Yaneth Herazo-Beltrán et al. · 2020 · Current Pharmaceutical Design
  40. In VitroandIn VivoEffects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose Tissue
    Agnieszka Śmieszek, Katarzyna Basińska, Klaudia Chrząstek, Krzysztof Marycz · 2015 · Journal of Diabetes Research
  41. Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis
    Yiwei Dong, Yanqiang Shi, Liwen He, Xi-yu Cui, Peizhu Su · 2017 · Oncotarget
  42. Sex differences and aging: Is there a role of brown adipose tissue?
    Jessica M. Hoffman, Teresa G. Valencak · 2021 · Molecular and Cellular Endocrinology
  43. M(o)TOR of aging: MTOR as a universal molecular hypothalamus
    Mikhail V. Blagosklonny · 2013 · Aging
  44. Do metformin a real anticarcinogen? A critical reappraisal of experimental data.
    Vladimir Nikolaevich Anisimov · 2014 · PubMed Central
  45. Growth or longevity: the TOR’s decision on lifespan regulation
    Yuehua Wei, Yanjie Zhang, Ying Cai · 2013 · Biogerontology
  46. Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiac hypertrophy
    Rongrong Sun, Baoling Zhu, Kai Xiong, Yan Sun, Dandan Shi, Li Chen, Youyi Zhang, Zijian Li, Lixiang Xue · 2017 · PLoS ONE
  47. Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs
    Sven Bulterijs, Bart P. Braeckman · 2020 · Pharmaceuticals
  48. Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine
    William H. Chappell, Stephen Lee Abrams, Richard A. Franklin, Michelle M. LaHair, Giuseppe Montalto, Melchiorre Cervello, Alberto Maria Martelli, Ferdinando Nicoletti, Saverio Candido, Massimo Libra et al. · 2012 · Cell Cycle
  49. Clinical perspectives and concerns of metformin as an anti‐aging drug
    Chuyao Wang, Bangwei Chen, Qian Feng, Chao Nie, Tao Li · 2020 · Aging Medicine
  50. The Regulation of the AMPK/mTOR Axis Mitigates Tendon Stem/Progenitor Cell Senescence and Delays Tendon Aging
    Guang-Chun Dai, Yingjuan Li, Ming Zhang, Panpan Lu, Yuanwei Zhang, Hao Wang, Liu Shi, Mu‐Min Cao, Renwang Shen, Yunfeng Rui · 2023 · Stem Cell Reviews and Reports
  51. Energy Metabolism and Metabolic Sensors in Stem Cells: The Metabostem Crossroads of Aging and Cancer
    Javier Abel Menéndez, Jorge Joven · 2014 · Advances in experimental medicine and biology
  52. The interplay between mitochondrial protein and iron homeostasis and its possible role in ageing
    Venkatesh Mallikarjun, Ashwin Sriram, Filippo Scialò, Alberto Sanz · 2014 · Experimental Gerontology
  53. Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules
    Surinder Kumar, David B. Lombard · 2016 · F1000Research
  54. Intelligent high‐throughput intervention testing platform in Daphnia
    Yongmin Cho, Rachael A Jonas-Closs, Lev Y. Yampolsky, Marc W. Kirschner, Leonid Peshkin · 2022 · Aging Cell
  55. Breaking the Ceiling of Human Maximal Life span
    Moshe Shay Ben-Haim, Yariv Kanfi, Sarah Jayne Mitchell, Noam Maoz, Kelli L. Vaughan, Ninette Amariglio, Batia Lerrer, Rafael de Cabo, Gideon Rechavi, Haim Yosef Cohen · 2017 · The Journals of Gerontology Series A
  56. Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes
    Garcia-Martin, Isabel, Penketh, Richard J. A., Janssen, Anna B., Jones, Rhiannon E., Grimstead, Julia, Baird, Duncan M., John, Rosalind M. · 2018 · PLOS ONE
  57. Senotherapeutics in Cancer and HIV
    Laura Sánchez-Díaz, Asunción Espinosa-Sánchez, José Ramón Blanco, Amancio Carnero · 2022 · Cells
  58. Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts
    Zoe E. Gillespie, Chenxuan Wang, Flaviu Vadan, Topaza Y. Yu, Juan Ausió, ANTHONY J. KUSALIK, Christopher H. Eskiw · 2019 · Scientific Reports
  59. Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet
    Dushani L. Palliyaguru, Robin K. Minor, Sarah Jayne Mitchell, Hector H. Palacios, Jordan J. Licata, Theresa M. Ward, Gelareh A. Abulwerdi, Peter J. Elliott, Christoph Heiner Westphal, James L. Ellis et al. · 2020 · The Journals of Gerontology Series A
  60. Involvement of NRF2 and AMPK signaling in aging and progeria: a digest
    Eleni Petsouki, Vasileios Gerakopoulos, Despoina D. Gianniou, Elke H. Heiß, Ioannis P. Trougakos · 2025 · Redox Biology
  61. One-carbon metabolism: An aging-cancer crossroad for the gerosuppressant metformin
    Javier Abel Menéndez, Jorge Joven · 2013 · Aging
  62. A 2D analysis of correlations between the parameters of the Gompertz–Makeham model (or law?) of relationships between aging, mortality, and longevity
    Alexey G. Golubev · 2019 · Biogerontology
  63. Emerging uncertainty on the anti-aging potential of metformin
    Matthew Thomas Keys, Jesper Hallas, Richard A. Miller, Samy Suissa, Kaare Christensen · 2025 · Ageing Research Reviews
  64. Repurposing Metformin for Vascular Disease
    Chris R. Triggle, Isra Marei, Kevin Ye, Hong Ding, Todd J. Anderson, Morley Donald Hollenberg, Michael A. Hill · 2022 · Current Medicinal Chemistry
  65. Les nouvelles promesses de la metformine
    Marc Foretz, Benoı̂t Viollet · 2014 · médecine/sciences
  66. Metformin Prevents H₂O₂-Induced Senescence in Human Lens Epithelial B3 Cells
    Chunmei Zhang, Mengmeng Chen, Nan Zhou, Yanhua Qi · 2020 · Medical science monitor basic research/Medical science monitor. Basic research
  67. Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle
    Ignacio Navas‐Enamorado, Michel Bernier, Gloria Brea‐Calvo, Rafael de Cabo · 2017 · Ageing Research Reviews
  68. Pharmacological Approaches to Decelerate Aging: A Promising Path
    Bahareh Hassani, Ghazal Goshtasbi, Shirin Nooraddini, Negar Firouzabadi · 2022 · Oxidative Medicine and Cellular Longevity
  69. The development and benefits of metformin in various diseases
    Ying Dong, Yingbei Qi, Haowen Jiang, Mi Tian, Yunkai Zhang, Chang Si Peng, Wan-Chen Li, Yi Zhang, Yubo Zhou, Yi Zang et al. · 2023 · Frontiers of Medicine
  70. Mitophagy-promoting agents and their ability to promote healthy-aging
    Vijigisha Srivastava, Einav Gross · 2023 · Biochemical Society Transactions
  71. The Interconnections Between Somatic and Ovarian Aging in Murine Models
    Augusto Schneider, Tatiana D. Saccon, Driele Neske Garcia, Bianka M. Zanini, José V.V. Isola, Jéssica D. Hense, Joao Alveiro Alvarado Rincón, Marcelo Borges Cavalcante, Jeffrey B. Mason, Michael B. Stout et al. · 2020 · The Journals of Gerontology Series A
  72. An overview of two decades of diet restriction studies using Drosophila
    Sudhakar Krittika, Pankaj Yadav · 2019 · Biogerontology
  73. Metformin extends the chronological lifespan of fission yeast by altering energy metabolism and stress resistance capacity
    Ceren Şeylan, Çağatay Tarhan · 2023 · FEMS Yeast Research
  74. YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype
    Masatomo Chiba, Kenichi Miyata, Hikaru Okawa, Yôko Tanaka, Koji Ueda, Hiroyuki Seimiya, Akiko Takahashi · 2023 · International Journal of Molecular Sciences
  75. Cellular senescence by loss of Men1 in osteoblasts is critical for age‐related osteoporosis
    Yuichiro Ukon, Takashi Kaito, Hiromasa Hirai, Takayuki Kitahara, Masayuki Bun, Joe Kodama, Daisuke Tateiwa, Shinichi Nakagawa, Masato Ikuta, Takuya Furuichi et al. · 2024 · Aging Cell
  76. Applying parametric models to survival data: tradeoffs between statistical significance, biological plausibility, and common sense
    Alexey G. Golubev, Андрей Владимирович Панченко, Vladimir Nikolaevich Anisimov · 2018 · Biogerontology
  77. Is metformin a geroprotector? A peek into the current clinical and experimental data
    Agnieszka Zajda, Kristiina M. Huttunen, Joanna Sikora, Maria Podsiedlik, Magdalena Markowicz-Piasecka · 2020 · Mechanisms of Ageing and Development
  78. Metformin inhibits human spermatozoa motility and signalling pathways mediated by protein kinase A and tyrosine phosphorylation without affecting mitochondrial function
    Violeta Calle-Guisado, Lauro González‐Fernández, David Martín‐Hidalgo, Luis J Garcı́a, Maria Julia Bragado · 2018 · Reproduction Fertility and Development
  79. Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research
    Breno Satler Diniz, Johanna Seitz‐Holland, Raghav Sehgal, Jessica Kasamoto, Albert Higgins‐Chen, Eric J. Lenze · 2023 · American Journal of Geriatric Psychiatry
  80. A blast from the past: To tame time with metformin
    Dionysios Xenos, Patrizia Mecocci, Virginia Boccardi · 2022 · Mechanisms of Ageing and Development
  81. Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks
    Mallikarjun, Venkatesh, Swift, Joe · 2016 · EBioMedicine
  82. Effects of lifespan-extending interventions on cognitive healthspan
    Luka Čulig, Burcin Duan Sahbaz, Vilhelm A. Bohr · 2022 · Expert Reviews in Molecular Medicine
  83. Pharmaceutical Intervention of Aging
    Minxian Qian, Baohua Liu · 2018 · Advances in experimental medicine and biology
  84. Dietary Restriction: Critical Co-Factors to Separate Health Span from Life Span Benefits
    Andrew R. Mendelsohn, James W. Larrick · 2012 · Rejuvenation Research
  85. Discovering Biological Mechanisms of Exceptional Human Health Span and Life Span
    Sofiya Milman, Nir Barzilai · 2023 · Cold Spring Harbor Perspectives in Medicine
  86. The goal of geroscience is life extension
    Mikhail V. Blagosklonny · 2021 · Oncotarget
  87. Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline
    Luke Slade, Timothy Etheridge, Nathaniel J. Szewczyk · 2024 · Ageing Research Reviews
  88. Tackling the Aging Process With Bio-Molecules: A Possible Role for Caloric Restriction, Food-derived Nutrients, Vitamins, Amino Acids, Peptides, and Minerals
    Prachi Dabhade, Swati D. Kotwal · 2013 · Journal of Nutrition in Gerontology and Geriatrics
  89. Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?
    Harvir Hans, Asad Lone, Vadim Aksenov, C. David Rollo · 2015 · AGE
  90. Impact of Concomitant Medications on Biochemical Outcome in Localised Prostate Cancer Treated with Radiotherapy and Androgen Deprivation Therapy
    Soumyajit Roy, Shawn Christopher Malone, Scott Grimes, Scott Carlyle Morgan · 2020 · Clinical Oncology
  91. Alive and well? Exploring disease by studying lifespan
    Brett, Jamie O, Rando, Thomas A · 2014 · Current Opinion in Genetics & Development
  92. Metabolic dysregulation of trained immunity in immune aging and the impact of dietary patterns
    Andra Grigorescu, Anca‐Lelia Riza, Ioana Streață, Mihai G. Netea · 2025 · American Journal of Physiology-Cell Physiology
  93. Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice
    Huan Liu, Gang Wei, Tongxing Wang, Yunlong Hou, Bin Hou, Xiaoyan Li, Chao Wang, Mingzhe Sun, Min Su, Zhifang Guo et al. · 2024 · Redox Report
  94. Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus
    Xuemei Yin, Yinzi Sui, Zhengyan Chu, Suqing Han, Xiaodong Ge, Tingting Liu, Feng Zeng, Ligen Chen, Rong Shao, Wei Xu · 2024 · Frontiers in Nutrition
  95. Metformin Attenuates Early-Stage Atherosclerosis in Mildly Hyperglycemic Oikawa-Nagao Mice
    Akira Asai, Yuki Shuto, Mototsugu Nagao, Momoyo Kawahara, Teruo Miyazawa, Hitoshi Sugihara, Shinichi Oikawa · 2019 · Journal of Atherosclerosis and Thrombosis
  96. New Directions in Research on Aging
    Andrzej Bartke · 2021 · Stem Cell Reviews and Reports
  97. Carving the senescent phenotype by the chemical reactivity of catecholamines: An integrative review
    Aleksei G. Golubev · 2022 · Ageing Research Reviews
  98. Metformin, Microbes, and Aging
    Gilles Storelli, Mélisandre A. Téfit, François Leulier · 2013 · Cell Metabolism
  99. New Insight into Metformin Mechanism of Action and Clinical Application
    Yun Yan, Karen L. Kover, Wayne V. Moore · 2020 · IntechOpen eBooks
  100. Molecular crosstalk for longevity: exercise and the AMPK/SIRT1/PGC-1α/Irisin/BDNF axis
    Ricardo Augusto Leoni De Sousa · 2025 · Molecular Biology Reports