If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
Anisimov, Vladimir N., Berstein, Lev M., Popovich, Irina G., Zabezhinski, Mark A., Egormin, Peter A., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Margarita L., Yurova, Maria N., Kovalenko, Irina G., Poroshina, Tatiana E.·2011·Aging
Cited by (284)
Items 101–200 of 284
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- Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespanMichelle T. Burstein, Pavlo Kyryakov, Adam Beach, Vincent R. Richard, Olivia Koupaki, Alejandra Gomez-Perez, Anna Leonov, Sean Levy, Forough Noohi, Vladimir I. Titorenko · 2012 · Cell Cycle
- Stem Cell Senescence and Regenerative ParadigmsAntonio Paolo Beltrami, Daniela Cesselli, Carlo Alberto Beltrami · 2011 · Clinical Pharmacology & Therapeutics
- Disease or not, aging is easily treatableMikhail V. Blagosklonny · 2018 · Aging
- Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life SpanSofiya Milman, Nir Barzilai · 2015 · Cold Spring Harbor Perspectives in Medicine
- The Mitochondria-Targeted Antioxidant SkQ1 but Not N-Acetylcysteine Reverses Aging-Related Biomarkers in RatsKolosova, Nataliya G., Stefanova, Natalia A., Muraleva, Natalia A., Skulachev, Vladimir P. · 2012 · Aging
- Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated agingOlga V. Leontieva, Geraldine Paszkiewicz, Mikhail V. Blagosklonny · 2012 · Aging
- Immunosuppressants in cancer prevention and therapyMikhail V. Blagosklonny · 2013 · OncoImmunology
- Metformin, aging and cancerOlga V. Moiseeva, Xavier Deschênes‐Simard, Michaël Pollak, Gerardo Ferbeyre · 2013 · Aging
- Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of InterventionsWeiyi Shen, Jiamin He, Tongyao Hou, Jianmin Si, Shujie Chen · 2022 · Aging and Disease
- Evaluation for clinical benefit of metformin in patients with idiopathic pulmonary fibrosis and type 2 diabetes mellitus: a national claims-based cohort analysisTaylor Teague, Stephanie R. Payne, Bryan T. Kelly, Timothy M. Dempsey, Rozalina G. McCoy, Lindsey R. Sangaralingham, ANDREW HAR LIMPER · 2022 · Respiratory Research
- The effect of metformin on cognitive function: A systematic review and meta-analysisOzra Tabatabaei‐Malazy, Fatemeh Bandarian, Mostafa Qorbani, Shahrzad Mohseni, Somayeh Mirsadeghi, Maryam Peimani, Bagher A. Larijani · 2022 · Journal of Psychopharmacology
- Selective anti-cancer agents as anti-aging drugsMikhail V. Blagosklonny · 2013 · Cancer Biology & Therapy
- Dietary restriction and the pursuit of effective mimeticsColin Selman · 2014 · Proceedings of The Nutrition Society
- Effect of Metformin on Viability, Morphology, and Ultrastructure of Mouse Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells and Balb/3T3 Embryonic Fibroblast Cell LineAgnieszka Śmieszek, Aleksandra Anna Czyrek, Katarzyna Basińska, Justyna Trynda, Aneta Skaradzińska, Anna Siudzińska, Monika Marędziak, Krzysztof Marycz · 2015 · BioMed Research International
- Anti-Diabetic Effects of Ethanol Extract from Sanghuangporous vaninii in High-Fat/Sucrose Diet and Streptozotocin-Induced Diabetic Mice by Modulating Gut MicrobiotaZirui Huang, Liyuan Zhao, Fu-Rong Zhu, Yun Liu, Jian-Yong Xiao, Zhichao Chen, Xu‐Cong Lv, Ying Huang, Bin Liu · 2022 · Foods
- AMPK as a Pro-longevity TargetKristopher Burkewitz, Heather J. M. Weir, William B. Mair · 2016 · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions
- Metformin and cognition from the perspectives of sex, age, and diseaseKiran Chaudhari, Conner D. Reynolds, Shao-Hua Yang · 2020 · GeroScience
- Lifespan Modulation in Mice and the Confounding Effects of Genetic BackgroundLorna Mulvey, Amy Sinclair, Colin Selman · 2014 · Journal of genetics and genomics/Journal of Genetics and Genomics
- Diet Modification and Metformin Have a Beneficial Effect in a Fly Model of Obesity and MucormycosisFazal Shirazi, Dimitrios Farmakiotis, Yuanqing Yan, Nathaniel D. Albert, Kim-Anh Do, Dimitrios P. Kontoyiannis · 2014 · PLoS ONE
- Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questionsMikhail V. Blagosklonny · 2012 · Oncotarget
- Potential Anti-Aging Substances Derived from SeaweedsLei Cao, Sang Gil Lee, Kwon Taek Lim, Hyeung‐Rak Kim · 2020 · Marine Drugs
- In search of antiaging modalities: Evaluation of mTOR‐ and ROS/DNA damage‐signaling by cytometryZbigniew Darżynkiewicz, Hong Zhao, H. Dorota Halicka, Jiangwei Li, Yong‐Syu Lee, Tze‐chen Hsieh, JOSEPH M. WU · 2014 · Cytometry Part A
- Taming expectations of metformin as a treatment to extend healthspanAdam R. Konopka, Benjamin F. Miller · 2019 · GeroScience
- Metformin monotherapy downregulates diabetes-associated inflammatory status and impacts on mortalityTizazu, Anteneh Mehari, Nyunt, Ma Shwe Zin, Cexus, Olivier, Suku, Koolarina, Mok, Esther, Xian, Chin Hui, Chong, Joni, Tan, Crystal, How, Wilson, Hubert, Sandra et al. · 2019 · Frontiers in Physiology
- Metformin As a GeroprotectorSven Bulterijs · 2011 · Rejuvenation Research
- Targeting ageing and preventing organ degeneration with metforminAnthony Paulo Sunjaya, Angela Felicia Sunjaya · 2020 · Diabetes & Metabolism
- STOP accelerating lung aging for the treatment of COPDKazuhiro Ito, Nicolas Mercado · 2014 · Experimental Gerontology
- Metabolaging: a new geroscience perspective linking aging pathologies and metabolic dysfunctionFadi Khalaf, Dalia Barayan, Sean Saldanha, Marc G. Jeschke · 2025 · Metabolism
- Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeastKyung-Mi Choi, Hye-Lan Lee, Young-Yon Kwon, Mi-Sun Kang, Sung-Keun Lee, Cheol‐Koo Lee · 2013 · Biochemical and Biophysical Research Communications
- Metformin: A Rising Star to Fight the Epithelial Mesenchymal Transition in OncologyGuislaine Barrière, Michel Tartary, Michel Rigaud · 2013 · Anti-Cancer Agents in Medicinal Chemistry
- The Function of Metformin in Aging-Related Musculoskeletal DisordersYanhong Song, Ziyi Wu, Ping Zhao · 2022 · Frontiers in Pharmacology
- Mechanisms of ageing: growth hormone, dietary restriction, and metforminJansher Khan, Ida Pernicova, Kiran Nisar, Márta Korbonits · 2023 · The Lancet Diabetes & Endocrinology
- Age‐related AMP‐activated protein kinase alterations: From cellular energetics to longevityМоргунова Галина Васильевна, А. А. Клебанов · 2019 · Cell Biochemistry and Function
- Fibroblast Growth Factor-21 Is a Promising Dietary Restriction MimeticAndrew R. Mendelsohn, James W. Larrick · 2012 · Rejuvenation Research
- Dysregulation of the mTOR pathway in p53-deficient miceOlga V. Leontieva, Liliya R. Novototskaya, Geraldine Paszkiewicz, Elena A Komarova, Andrei V. Gudkov, Mikhail V. Blagosklonny · 2013 · Cancer Biology & Therapy
- Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female MiceXudong Zhu, Weiyan Shen, Zhu Liu, Shihao Sheng, Wei Xiong, Ruikun He, Xuguang Zhang, Likun Ma, Zhenyu Ju · 2021 · Frontiers in Cell and Developmental Biology
- AMPK activation—protean potential for boosting healthspanMark Frederick McCarty · 2013 · AGE
- Anti-Aging Effect of Metformin: A Molecular and Therapeutical PerspectiveWheeler Torres, Manuel Nava, Néstor Galbán, Yosselin Gómez, Valery Morillo, Milagros Rojas, Clímaco Cano, Maricarmen Chacín, Luis D’Marco, Yaneth Herazo-Beltrán et al. · 2020 · Current Pharmaceutical Design
- In VitroandIn VivoEffects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose TissueAgnieszka Śmieszek, Katarzyna Basińska, Klaudia Chrząstek, Krzysztof Marycz · 2015 · Journal of Diabetes Research
- Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysisYiwei Dong, Yanqiang Shi, Liwen He, Xi-yu Cui, Peizhu Su · 2017 · Oncotarget
- Sex differences and aging: Is there a role of brown adipose tissue?Jessica M. Hoffman, Teresa G. Valencak · 2021 · Molecular and Cellular Endocrinology
- M(o)TOR of aging: MTOR as a universal molecular hypothalamusMikhail V. Blagosklonny · 2013 · Aging
- Do metformin a real anticarcinogen? A critical reappraisal of experimental data.Vladimir Nikolaevich Anisimov · 2014 · PubMed Central
- Growth or longevity: the TOR’s decision on lifespan regulationYuehua Wei, Yanjie Zhang, Ying Cai · 2013 · Biogerontology
- Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiac hypertrophyRongrong Sun, Baoling Zhu, Kai Xiong, Yan Sun, Dandan Shi, Li Chen, Youyi Zhang, Zijian Li, Lixiang Xue · 2017 · PLoS ONE
- Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective DrugsSven Bulterijs, Bart P. Braeckman · 2020 · Pharmaceuticals
- Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberineWilliam H. Chappell, Stephen Lee Abrams, Richard A. Franklin, Michelle M. LaHair, Giuseppe Montalto, Melchiorre Cervello, Alberto Maria Martelli, Ferdinando Nicoletti, Saverio Candido, Massimo Libra et al. · 2012 · Cell Cycle
- Clinical perspectives and concerns of metformin as an anti‐aging drugChuyao Wang, Bangwei Chen, Qian Feng, Chao Nie, Tao Li · 2020 · Aging Medicine
- The Regulation of the AMPK/mTOR Axis Mitigates Tendon Stem/Progenitor Cell Senescence and Delays Tendon AgingGuang-Chun Dai, Yingjuan Li, Ming Zhang, Panpan Lu, Yuanwei Zhang, Hao Wang, Liu Shi, Mu‐Min Cao, Renwang Shen, Yunfeng Rui · 2023 · Stem Cell Reviews and Reports
- Energy Metabolism and Metabolic Sensors in Stem Cells: The Metabostem Crossroads of Aging and CancerJavier Abel Menéndez, Jorge Joven · 2014 · Advances in experimental medicine and biology
- The interplay between mitochondrial protein and iron homeostasis and its possible role in ageingVenkatesh Mallikarjun, Ashwin Sriram, Filippo Scialò, Alberto Sanz · 2014 · Experimental Gerontology
- Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging MoleculesSurinder Kumar, David B. Lombard · 2016 · F1000Research
- Intelligent high‐throughput intervention testing platform in DaphniaYongmin Cho, Rachael A Jonas-Closs, Lev Y. Yampolsky, Marc W. Kirschner, Leonid Peshkin · 2022 · Aging Cell
- Breaking the Ceiling of Human Maximal Life spanMoshe Shay Ben-Haim, Yariv Kanfi, Sarah Jayne Mitchell, Noam Maoz, Kelli L. Vaughan, Ninette Amariglio, Batia Lerrer, Rafael de Cabo, Gideon Rechavi, Haim Yosef Cohen · 2017 · The Journals of Gerontology Series A
- Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetesGarcia-Martin, Isabel, Penketh, Richard J. A., Janssen, Anna B., Jones, Rhiannon E., Grimstead, Julia, Baird, Duncan M., John, Rosalind M. · 2018 · PLOS ONE
- Senotherapeutics in Cancer and HIVLaura Sánchez-Díaz, Asunción Espinosa-Sánchez, José Ramón Blanco, Amancio Carnero · 2022 · Cells
- Metformin induces the AP-1 transcription factor network in normal dermal fibroblastsZoe E. Gillespie, Chenxuan Wang, Flaviu Vadan, Topaza Y. Yu, Juan Ausió, ANTHONY J. KUSALIK, Christopher H. Eskiw · 2019 · Scientific Reports
- Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat DietDushani L. Palliyaguru, Robin K. Minor, Sarah Jayne Mitchell, Hector H. Palacios, Jordan J. Licata, Theresa M. Ward, Gelareh A. Abulwerdi, Peter J. Elliott, Christoph Heiner Westphal, James L. Ellis et al. · 2020 · The Journals of Gerontology Series A
- Involvement of NRF2 and AMPK signaling in aging and progeria: a digestEleni Petsouki, Vasileios Gerakopoulos, Despoina D. Gianniou, Elke H. Heiß, Ioannis P. Trougakos · 2025 · Redox Biology
- One-carbon metabolism: An aging-cancer crossroad for the gerosuppressant metforminJavier Abel Menéndez, Jorge Joven · 2013 · Aging
- A 2D analysis of correlations between the parameters of the Gompertz–Makeham model (or law?) of relationships between aging, mortality, and longevityAlexey G. Golubev · 2019 · Biogerontology
- Emerging uncertainty on the anti-aging potential of metforminMatthew Thomas Keys, Jesper Hallas, Richard A. Miller, Samy Suissa, Kaare Christensen · 2025 · Ageing Research Reviews
- Repurposing Metformin for Vascular DiseaseChris R. Triggle, Isra Marei, Kevin Ye, Hong Ding, Todd J. Anderson, Morley Donald Hollenberg, Michael A. Hill · 2022 · Current Medicinal Chemistry
- Les nouvelles promesses de la metformineMarc Foretz, Benoı̂t Viollet · 2014 · médecine/sciences
- Metformin Prevents H₂O₂-Induced Senescence in Human Lens Epithelial B3 CellsChunmei Zhang, Mengmeng Chen, Nan Zhou, Yanhua Qi · 2020 · Medical science monitor basic research/Medical science monitor. Basic research
- Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscleIgnacio Navas‐Enamorado, Michel Bernier, Gloria Brea‐Calvo, Rafael de Cabo · 2017 · Ageing Research Reviews
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- The development and benefits of metformin in various diseasesYing Dong, Yingbei Qi, Haowen Jiang, Mi Tian, Yunkai Zhang, Chang Si Peng, Wan-Chen Li, Yi Zhang, Yubo Zhou, Yi Zang et al. · 2023 · Frontiers of Medicine
- Mitophagy-promoting agents and their ability to promote healthy-agingVijigisha Srivastava, Einav Gross · 2023 · Biochemical Society Transactions
- The Interconnections Between Somatic and Ovarian Aging in Murine ModelsAugusto Schneider, Tatiana D. Saccon, Driele Neske Garcia, Bianka M. Zanini, José V.V. Isola, Jéssica D. Hense, Joao Alveiro Alvarado Rincón, Marcelo Borges Cavalcante, Jeffrey B. Mason, Michael B. Stout et al. · 2020 · The Journals of Gerontology Series A
- An overview of two decades of diet restriction studies using DrosophilaSudhakar Krittika, Pankaj Yadav · 2019 · Biogerontology
- Metformin extends the chronological lifespan of fission yeast by altering energy metabolism and stress resistance capacityCeren Şeylan, Çağatay Tarhan · 2023 · FEMS Yeast Research
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- Applying parametric models to survival data: tradeoffs between statistical significance, biological plausibility, and common senseAlexey G. Golubev, Андрей Владимирович Панченко, Vladimir Nikolaevich Anisimov · 2018 · Biogerontology
- Is metformin a geroprotector? A peek into the current clinical and experimental dataAgnieszka Zajda, Kristiina M. Huttunen, Joanna Sikora, Maria Podsiedlik, Magdalena Markowicz-Piasecka · 2020 · Mechanisms of Ageing and Development
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- Alive and well? Exploring disease by studying lifespanBrett, Jamie O, Rando, Thomas A · 2014 · Current Opinion in Genetics & Development
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