The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Exceptional longevity is associated with decreased reproduction
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The negative genetic correlation between fertility and longevity supports the AP theory of aging.
“supporting the AP theory of aging7,16,50,51”
From Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans (2026) · cites this paper as [51]
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Cites
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Longevity and the costs of reproduction in a historical human population
Lycett, J. E., Dunbar, R. I. M., & Voland, E. (2000) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.2000.0962 · Cited by 162
Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
Blagosklonny, M. V. (2010) · Cell Cycle · doi:10.4161/cc.9.16.13120 · Cited by 160
Flagged first, then by citations
Research works printed but not linked: 22
- Rose, 1991, Evolution of Senescence: Later Survival Sacrificed for Reproduction, Philos Trans R Soc Lond B Biol Sci, 33, 15
- Kirkwood, 1998, Human Longevity at the Cost of Reproductive Success, Nature, 39, 743
- Korpelainen, 2000, Fitness, Reproduction and Longevity Among European Aristocratic and Rural Finnish Families in the 1700s and 1800s, Proc Biol Soc, 26, 1765, 10.1098/rspb.2000.1208 · DOI
- Kerber, 2009, Effects of Childhood and Middle-adulthood Family Conditions on Later-life Mortality: Evidence from the Utah Population Database, 1850-2002, Soc Sci Med, 9, 1649
- Doblhammer, 2000, Reproductive History and Mortality Later in Life: A Comparative Study of England and Wales and Austria, Popul Stud, 5, 169, 10.1080/713779087 · DOI
- Wang, 2002, Fertility and Lifespan: Later Children Enhance Female Longevity, J Gerontol A Biol Sci Med Sci, 5, 202
- Mitchell, 2006, Does Having Children Extend Life Span? A Genealogical Study of Parity and Longevity in the Amish, J Gerontol A Biol Sci Med Sci, 6, 190
- Kravdal, 2010, Fertility History and Cause-specific Mortality: a Register-based Analysis of Complete Cohorts of Norwegian Women and Men, Soc Sci Med, 7, 1847
- Charbonneau, 1993, Reproductive Life of French-Canadians in the 17-18Centuries: A search for a Trade-off Between Early Fecundity and Longevity, Exp Gerontol, 2, 217
- Engel, 1986, Is the Postmenopausal age at death variable a fitness-maximizing reproductive strategy?, Anthropol Anz, 4, 19
- Le Bourge, 2007, Does Reproduction Decrease Longevity in Human Beings?, Aging Res Rev, 6, 141, 10.1016/j.arr.2007.04.002 · DOI
- Atwood, 2004, Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones, Gerontology, 5, 265
- Bowen, 2010, The Reproductive-Cell Cycle Theory of Aging: An Update, Experimental Gerontology, 4, 100
- Fretts, 1997, Middle-aged Mothers Live Longer, Nature, 38, 133
- Sorkin, 2001, Offspring of Centenarians Have a Favorable Lipid Profile, J Am Geriatr Soc, 4, 76
- Barzilai, 2002, Plasma HDL levels Highly Correlate with Cognitive Function in Exceptional Longevity, J Gerontol A Biol Sci Med Sci, 5, 712
- Blagosklonny, 2010, Why Men Age Faster but Reproduce Longer than Women: mTOR and Evolutionary Prespectives, Aging, 2, 265, 10.18632/aging.100149 · DOI
- Weichhart, 2012, Mammalian Target of Rapamycin: a Signaling Kinase for Every Aspect of Cellular Life, Methods in Molecular Biology, 82, 1
- Tena-Sempere, 2009, The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System, Endocrinology, 15, 5016
- Wuttenbach, 2009, mTOR's Role in Ageing: Protein Synthesis or Authophagy?, Aging (Albany NY), 1, 586
- Shuldiner, 2003, Unique Lipoprotein Phenotype and Genotype Associated with Exceptional Longevity, JAMA, 29, 2030
- Atzmon, 2010, Cholesteryl Ester Transfer Protein (CETP) Genotype and Reduced CETP Levels Associated With Decreased Prevalence of Hypertension, Mayo Clinic Proceedings, 8, 522
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Thyroid Hormone Signaling and Homeostasis During Aging
Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117
Brigos-Barril, E., Vasallo, C., Farré, X., Morcillo-Suárez, C., Polo-Alonso, S., Rodríguez-Fernández, B., Valenzuela, A., Sarabia, C., Bosch, E., Laayouni, H., et al. (2026) · Nature Ecology & Evolution · doi:10.1038/s41559-026-03140-z · Cited by 6
Metadata
- Authors
- Tabatabaie, V., Atzmon, G., Rajpathak, S. N., Freeman, R., Barzilai, N., & Crandall, J.
- Affiliations
- Institute for Aging Research, and Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2011-12-26
- Volume
- 3
- Issue
- 12
- Pages
- 1202-1205
- ISSN
- 1945-4589
- PMC
- PMC3273900
- Cited by
- 46
- References
- 3
- Language
- en
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