CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats
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/NADH ratio and Sirt3 activity in renal proximal tubular HK-2 cells cultured under high-glucose conditions. Together, these results demonstrate that by inhibiting the Sirt3 activity and increasing mitochondrial oxidative stress in renal tubular cells, CD38 plays a crucial role in the pathogenesis of DKD.
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Apigenin lowers CD38 expression in the kidneys of diabetic rats.
“More recently, apigenin has been shown to downregulate CD38 expression, and to increase the intracellular NAD+/NADH ratio and SIRT3-mediated mitochondrial antioxidative enzyme activity in the kidneys of diabetic rats227.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [227]
Apigenin raises the intracellular NAD+/NADH ratio in kidneys of diabetic rats.
“More recently, apigenin has been shown to downregulate CD38 expression, and to increase the intracellular NAD+/NADH ratio and SIRT3-mediated mitochondrial antioxidative enzyme activity in the kidneys of diabetic rats227.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [227]
Apigenin raises SIRT3-dependent mitochondrial antioxidant enzyme activity in kidneys of diabetic rats.
“More recently, apigenin has been shown to downregulate CD38 expression, and to increase the intracellular NAD+/NADH ratio and SIRT3-mediated mitochondrial antioxidative enzyme activity in the kidneys of diabetic rats227.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [227]
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- Authors
- Ogura, Y., Kitada, M., Xu, J., Monno, I., & Koya, D.
- Affiliations
- Kanazawa Medical University (JP)
- Corresponding author
- Kitada, Munehiro
- Koya, Daisuke
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2020-06-07
- Volume
- 12
- Issue
- 12
- Pages
- 11325-11336
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC7343471
- OpenAlex
- W3034018227
- Cited by
- 118
- References
- 32
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 22 · 2023: 23 · 2022: 17 · 2021: 15 · 2020: 2
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Kanazawa Medical University (24591218)
- Japan Society for the Promotion of Science (17K16104, 24591218)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- CD38, apigenin, diabetic nephropathy, mitochondrial oxidative stress, NAD+/NADH ratio, SIRT3, renal proximal tubular cells, HK-2 cells, high glucose, NAD+ salvage pathway
- MeSH terms
- Animals, Blood Glucose, Cell Line, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Disease Models, Animal, Epithelial Cells, Humans, Kidney Tubules, Proximal, Male, Membrane Glycoproteins, Mitochondria, NAD, Rats, Zucker, Oxidative Stress, ADP-ribosyl Cyclase, Sirtuins, Apigenin, Rats, ADP-ribosyl Cyclase 1, Gene Knockdown Techniques, Sirtuin 3
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