HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts
Open accessAbstract
. They are characterized by several biomarkers and changes in gene expression that may depend on epigenetic factors, such as histone acetylation, involving a balance between histone acetyltransferases (HATs) and histone deacetylases (HDACs). In this study, we investigate the expression and the role of HDACs on the senescent phenotype of dermal fibroblasts. We report that during replicative senescence, most canonical HDACs are less expressed. Moreover, treatment with SAHA, a histone deacetylase inhibitor (HDACi) also known as Vorinostat, or the specific downregulation of HDAC2 or HDAC7 by siRNA, induces the appearance of senescence biomarkers of dermal fibroblasts. Conversely, the ectopic re-expression of HDAC7 by lentiviral transduction in pre-senescent dermal fibroblasts extends their proliferative lifespan. These results demonstrate that HDACs expression can modulate the senescent phenotype, highlighting their pharmaceutical interest in the context of healthy ageing.
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HDAC7 is modulated during senescence.
“HDAC7 has also been reported to be modulated during senescence and its downregulation promotes senescence in fibroblasts (Warnon et al., 2021).”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Warnon et al., 2021
Downregulation of HDAC7 promotes senescence in fibroblasts.
“HDAC7 has also been reported to be modulated during senescence and its downregulation promotes senescence in fibroblasts (Warnon et al., 2021).”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Warnon et al., 2021
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- Authors
- Warnon, C., Bouhjar, K., Ninane, N., Verhoyen, M., Fattaccioli, A., Fransolet, M., Lambert de Rouvroit, C., Poumay, Y., Piel, G., Mottet, D., & Debacq-Chainiaux, F.
- Affiliations
- University of Namur (BE)
- URPHYM, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium
- University of Liège (BE)
- URBC, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2021-07-12
- Volume
- 13
- Issue
- 14
- Pages
- 17978-18005
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC8351730
- OpenAlex
- W3182281603
- Cited by
- 25
- References
- 51
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Repository of the University of Namur (submittedVersion, cc-by)
- Funders
- Fonds De La Recherche Scientifique - FNRS
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- HDAC2, HDAC7, histone deacetylase, replicative senescence, dermal fibroblasts, histone acetylation, histone deacetylase inhibitors, vorinostat, siRNA knockdown, senescence biomarkers, healthy aging, epigenetic regulation
- MeSH terms
- Vorinostat, Acetylation, Fibroblasts, Histone Deacetylases, Humans, Skin, Biomarkers, Down-Regulation, Cellular Senescence, Histone Deacetylase 2, Histone Deacetylase Inhibitors
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