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As predicted by hyperfunction theory, rapamycin treatment during development extends lifespan
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“The ability of rapamycin to promote longevity is consistent with the idea that mTOR activity is an example of antagonistic pleiotropy, with high mTOR signaling being beneficial for development and reproduction, but being harmful during a post-reproductive old age 109.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [109]
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
Blagosklonny, M. V. (2010) · Cell Cycle · doi:10.4161/cc.9.16.13120 · Cited by 160
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Research works printed but not linked: 47
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Cited by
Sorted by citations
Targeting the biology of aging with mTOR inhibitors
Mannick, J. B., & Lamming, D. W. (2023) · Nature Aging · doi:10.1038/s43587-023-00416-y · Cited by 372
Metadata
- Authors
- Blagosklonny, M. V.
- Affiliations
- Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2022-03-05
- Volume
- 14
- Issue
- 5
- Pages
- 2020-2024
- ISSN
- 1945-4589
- PMC
- PMC8954961
- Cited by
- 10
- References
- 2
- Language
- en
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