Cited by 680Hematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

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Chen, Chong, Liu, Yu, Liu, Yang, Zheng, Pan·2009·Science Signaling

Abstract

Rapamycin reverses aging-related declines in hematopoietic stem cell function.

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Crossref · 10.1126/scisignal.2000559

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Authors
Chen, C., Liu, Y., Liu, Y., & Zheng, P.
Affiliations
University of Michigan (US)
Corresponding author
  • Liu, Yang
  • Zheng, Pan
Venue
Science Signaling
Published
2009-11-24
Volume
2
Issue
98
Pages
ra75-ra75
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2169519600
Cited by
680
References
34
Citations by year
2026: 29 · 2025: 37 · 2024: 43 · 2023: 42 · 2022: 45 · 2021: 58 · 2020: 41 · 2019: 41 · 2018: 42 · 2017: 31 · 2016: 53 · 2015: 45 · 2014: 49 · 2013: 43 · 2012: 41
FWCI
17.94
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (P30AG024824)
  • National Cancer Institute (R01CA112001)
  • National Institute of General Medical Sciences (RC1GM091648)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
mTOR signaling, hematopoietic stem cells, stem cell aging, TSC1, rapamycin, cyclin-dependent kinase inhibitors, p16INK4a, p19ARF, p21, lymphocyte development, hematopoietic recovery, self-renewal, influenza vaccination, anemia, mTOR inhibitors
MeSH terms
Aging, Animals, Hematopoiesis, Hematopoietic Stem Cells, Male, Mice, Inbred C57BL, Orthomyxoviridae, Protein Kinases, Time Factors, Signal Transduction, Cyclin-Dependent Kinase Inhibitor p16, Sirolimus, Cyclin-Dependent Kinase Inhibitor p21, Mice, TOR Serine-Threonine Kinases

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