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A retrospective study of NENs and miR-224 promotes apoptosis of BON-1 cells by targeting PCSK9 inhibition

Bai, Jian’an, Na, He, Hua, Xiumei, Wei, Yaling, Ye, Tian, Zhang, Yiqiang, Jian, Guo, Zeng, Weiwen, Yan, Lijun, Tang, Qiyun·2017·Oncotarget
DOI 10.18632/oncotarget.14322PMC PMC5351680
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Crossref · 10.18632/oncotarget.14322

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  • miR-191, miR-221-5p, miR-222, miR-224, miR-342-5p, miR-363-5p, miR-483, miR-520d, miR-609, miR-765, miR-3165, and miR-1908-5p inhibit expression of PCSK9, increasing LDLR.

    “miR-191, miR-221-5p, miR-222, miR-224, miR-342-5p, miR-363-5p, miR-483, miR-520d, miR-609, miR-765, miR-3165, miR-1908-5p Inhibit expression of PCSK9 ↑ [50-55]”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [52]

    The Results section (‘PCSK9 is the direct target of miR-224,’ Figure 4) shows that miR-224 reduces PCSK9 expression in BON-1 cells. The paper does not establish PCSK9 inhibition for the other listed miRNAs, and although the Discussion says PCSK9 degrades the LDL receptor, it does not report an increase in LDLR following miR-224 treatment. Page numbers are unavailable in our copy. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • miR-224 and miR-520d inhibit expression of IDOL, increasing LDLR.

    “miR224, miR520d Inhibit expression of IDOL ↑ [50-55]”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [52]

    The Results section (page unavailable) shows that miR-224 reduces PCSK9 expression in BON-1 cells, and the Discussion identifies PCSK9 as a regulator of the LDL receptor. Our copy does not show that miR-224 inhibits IDOL, address miR-520d, or demonstrate an increase in LDLR. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 27

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  7. Cannon, 2015, PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: past, present, and the future, European heart journal
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Metadata

Authors
Bai, J., Na, H., Hua, X., Wei, Y., Ye, T., Zhang, Y., Jian, G., Zeng, W., Yan, L., & Tang, Q.
Affiliations
  • Department of Gastroenterology, Sir Run Run Hospital Affiliated with Nanjing Medical University, Nanjing, China
  • Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
  • Department of Radiology, Linyi People's Hospital, Dezhou, China
  • Department of Orthopaedics, Linyi People's Hospital, Dezhou, China
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2016-12-28
Volume
8
Issue
4
Pages
6929-6939
ISSN
1949-2553
DOI
10.18632/oncotarget.14322
PMC
PMC5351680
Cited by
41
References
0
Language
en

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